Articaine: Difference between revisions

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* Content


==Overview==
<!--Adult Indications and Dosage-->
{{Drugbox|  
 
| Image = Articaine.png
<!--FDA-Labeled Indications and Dosage (Adult)-->
| IUPAC_name = methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate hydrochloride
|fdaLIADAdult======Condition1=====
| ATC_prefix= ?
 
| ATC_suffix= ?
* Dosing Information
| PubChem= ?
 
| DrugBank= ?
:* Dosage
| CAS_number = 23964-57-0
 
| C=13 | H=20 | N=2 | O=3 | S=1
=====Condition2=====
| molecular_weight = 320.836 g/mol
 
| bioavailability = ?
* Dosing Information
| metabolism = [[Liver]], Plasma
 
| elimination_half-life = ?
:* Dosage
| excretion = ?
 
| pregnancy_category = ?
=====Condition3=====
| legal_status =  ?
 
| routes_of_administration = [[Subcutaneous]], ?
* Dosing Information
 
:* Dosage
 
=====Condition4=====
 
* Dosing Information
 
:* Dosage
 
<!--Off-Label Use and Dosage (Adult)-->
 
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* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
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=====Musculoskeletal=====
 
 
 
 
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<!--Drug Shortage Status-->
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}}
}}
{{SI}}
{{PillImage
'''Articaine''' is a dental local anesthetic. It is manufactured and distributed by Septodont under the brand name Septocaine. Articaine hydrochloride 4% with [[epinephrine]] 1:100,000 injection. Septocaine was first approved for use in Germany in 1976 and throughout Europe shortly after. Canada approved usage in 1982, with the US FDA following in 2000. Qualities such as fast acting nature and strength of dosage have made it more appealing for use by dentists than other available anesthetics such as [[novocaine]] and [[lidocaine]].
|fileName=No image.jpg
 
}}
== Structure and Metabolism ==
{{LabelImage
Articaine is unique among local anesthetics because it contains a [[thiophene]] group, and also because it contains both [[ester]] and [[amide]] groups.  Articaine is an amide anesthetic due to the amide intermediate chain, and undergoes hepatic metabolism.  However, the associated ester group also allows plasma metabolism via pseudocholinesterase, purportedly increasing the rate of breakdown and reducing its toxicity. This difference in metabolism gives articaine the distinct advantage of having a 30 minute half life, as opposed to drugs such as lidocaine that have a 90 min. half life.
|fileName={{PAGENAME}}11.png
}}
{{LabelImage
|fileName={{PAGENAME}}11.png
}}
<!--Pill Image-->


== Complications ==
NO Serious complications have been associated with Septocaine. Long-term or transient [[paresthesia]] is among the worst of the reported side effects of Septocaine but does not occur as frequently as with lidocaine. (JD)


It should be noted that almost all recorded cases of long term numbness or parasthesia in a dental setting are associated with a mandibular nerve block type injection and simple infiltration injections are generally thought to be immune from such complications.  For this reason many dentists have abandoned using articaine for mandibular nerve blocks.


==External links==
<!--Label Display Image-->
*[http://www.septodont.com Official Site]
*[http://www.chemindustry.com/chemicals/810897.html Structure]






{{Local anesthetics}}


[[Category:Anesthetics]]
[[Category:Dental equipment]]
[[Category:Thiophenes]]


[[de:Articain]]
<!--Category-->
[[fr:Articaïne]]
[[pt:Articaína]]


{{WikiDoc Help Menu}}
[[Category:Drug]]
{{WS}}

Revision as of 16:51, 30 January 2015

Articaine
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Articaine is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Articaine in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Articaine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Articaine in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Articaine in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Articaine in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Articaine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Articaine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Articaine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Articaine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Articaine with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Articaine with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Articaine with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Articaine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Articaine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Articaine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Articaine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Articaine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Articaine in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Articaine in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Articaine in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Articaine in the drug label.

Pharmacology

There is limited information regarding Articaine Pharmacology in the drug label.

Mechanism of Action

Structure

File:Articaine01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Articaine in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Articaine in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Articaine in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Articaine in the drug label.

How Supplied

Storage

There is limited information regarding Articaine Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Articaine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Articaine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Articaine in the drug label.

Precautions with Alcohol

  • Alcohol-Articaine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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Retrieved from "https://www.wikidoc.org/index.php?title=Articaine&oldid=1061352"