Loratadine: Difference between revisions

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====Idiopathic urticaria====
====Idiopathic urticaria====
*Dose: 10 mg PO daily
*Dose: 10 mg PO daily
|offLabelAdultGuideSupport=*[[Eosinophilic nonallergic rhinitis]]
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Loratadine in pediatric patients.
|offLabelAdultNoGuideSupport=====[[Asthma]]====  
|offLabelAdultNoGuideSupport=====[[Asthma]]====  
*10-20 mg PO daily up to 8 weeks <ref name="pmid9444440">{{cite journal| author=Menardo JL, Horak F, Danzig MR, Czarlewski W| title=A review of loratadine in the treatment of patients with allergic bronchial asthma. | journal=Clin Ther | year= 1997 | volume= 19 | issue= 6 | pages= 1278-93; discussion 1523-4 | pmid=9444440 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9444440  }} </ref><ref name="pmid9438487">{{cite journal| author=Corren J, Harris AG, Aaronson D, Beaucher W, Berkowitz R, Bronsky E et al.| title=Efficacy and safety of loratadine plus pseudoephedrine in patients with seasonal allergic rhinitis and mild asthma. | journal=J Allergy Clin Immunol | year= 1997 | volume= 100 | issue= 6 Pt 1 | pages= 781-8 | pmid=9438487 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9438487  }} </ref>
*10-20 mg PO daily up to 8 weeks <ref name="pmid9444440">{{cite journal| author=Menardo JL, Horak F, Danzig MR, Czarlewski W| title=A review of loratadine in the treatment of patients with allergic bronchial asthma. | journal=Clin Ther | year= 1997 | volume= 19 | issue= 6 | pages= 1278-93; discussion 1523-4 | pmid=9444440 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9444440  }} </ref><ref name="pmid9438487">{{cite journal| author=Corren J, Harris AG, Aaronson D, Beaucher W, Berkowitz R, Bronsky E et al.| title=Efficacy and safety of loratadine plus pseudoephedrine in patients with seasonal allergic rhinitis and mild asthma. | journal=J Allergy Clin Immunol | year= 1997 | volume= 100 | issue= 6 Pt 1 | pages= 781-8 | pmid=9438487 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9438487  }} </ref>
|fdaLIADPed=*5 mg PO daily
*[[Eosinophilic nonallergic rhinitis]]
|fdaLIADPed=====Seasonal allergic rhinitis====
*Dose 2-5 years: 5 mg PO daily
*Dose >6 years: 10 mg PO daily
====Idiopathic urticaria====
*Dose 2-5 years: 5 mg PO daily
*Dose >6 years: 10 mg PO daily
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Loratadine in pediatric patients.
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Loratadine in pediatric patients.
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Loratadine in pediatric patients.
|offLabelPedNoGuideSupport=====Asthma====
*<30 kg: 10 mg PO daily
*>30 kg: 20 mg PO daily
|contraindications=*Hypersensitivity to loratadine
|warnings=*Do not use if you have ever had an allergic reaction to this product or any of its ingredients
*Ask a doctor before use if you have liver or kidney disease. Your doctor should determine if you need a different dose.
*When using this product do not take more than directed. Taking more than directed may cause drowsiness.
*Stop use and ask a doctor is an allergic reaction to this product occurs. Seek medical help right away.
*If pregnant or breast-feeding, ask a health professional before use.
*Keep out of reach of children.
*In case of overdose, get medical help or contact a Poison Control Center right away.
|clinicalTrials=====Dermatologic====
*Rash
====Gastrointestinal====
*Abdominal pain
*Diarrhea
*Stomatitis
*Xerostomia
====Hepatic====
*Hepatic necrosis
*Hepatitis
*Jaundice
====Neurologic====
*Feeling nervous
*Headache
*Hyperactive behavior
*Somnolence
====Respiratory====
*Epistaxis
*Pharyngitis
*Upper respiratory infections
*Viral disease
*Wheezing
====Other====
*Difficulty speaking
*Fatigue
*Influenza-like symptoms 
*Malaise
*Somnolence
*Tooth disorder
|alcohol=Alcohol-Loratadine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
|alcohol=Alcohol-Loratadine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
}}
}}

Revision as of 17:44, 15 December 2014

Loratadine
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]

Disclaimer

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Overview

Loratadine is an antihistamine that is FDA approved for the treatment of runny nose, sneezing, itchy, watery eyes, itching of the nose or throat.. Common adverse reactions include Xerostomia, headache, somnolence and fatigue..

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Seasonal allergic rhinitis

  • Dose: 10 mg PO daily

Idiopathic urticaria

  • Dose: 10 mg PO daily

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Loratadine in pediatric patients.

Non–Guideline-Supported Use

Asthma

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Seasonal allergic rhinitis

  • Dose 2-5 years: 5 mg PO daily
  • Dose >6 years: 10 mg PO daily

Idiopathic urticaria

  • Dose 2-5 years: 5 mg PO daily
  • Dose >6 years: 10 mg PO daily

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Loratadine in pediatric patients.

Non–Guideline-Supported Use

Asthma

  • <30 kg: 10 mg PO daily
  • >30 kg: 20 mg PO daily

Contraindications

  • Hypersensitivity to loratadine

Warnings

  • Do not use if you have ever had an allergic reaction to this product or any of its ingredients
  • Ask a doctor before use if you have liver or kidney disease. Your doctor should determine if you need a different dose.
  • When using this product do not take more than directed. Taking more than directed may cause drowsiness.
  • Stop use and ask a doctor is an allergic reaction to this product occurs. Seek medical help right away.
  • If pregnant or breast-feeding, ask a health professional before use.
  • Keep out of reach of children.
  • In case of overdose, get medical help or contact a Poison Control Center right away.

Adverse Reactions

Clinical Trials Experience

Dermatologic

  • Rash

Gastrointestinal

  • Abdominal pain
  • Diarrhea
  • Stomatitis
  • Xerostomia

Hepatic

  • Hepatic necrosis
  • Hepatitis
  • Jaundice

Neurologic

  • Feeling nervous
  • Headache
  • Hyperactive behavior
  • Somnolence

Respiratory

  • Epistaxis
  • Pharyngitis
  • Upper respiratory infections
  • Viral disease
  • Wheezing

Other

  • Difficulty speaking
  • Fatigue
  • Influenza-like symptoms
  • Malaise
  • Somnolence
  • Tooth disorder

Postmarketing Experience

There is limited information regarding Loratadine Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Loratadine Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Loratadine in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Loratadine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Loratadine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Loratadine in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Loratadine in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Loratadine in geriatric settings.

Gender

There is no FDA guidance on the use of Loratadine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Loratadine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Loratadine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Loratadine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Loratadine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Loratadine in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Loratadine Administration in the drug label.

Monitoring

There is limited information regarding Loratadine Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Loratadine and IV administrations.

Overdosage

There is limited information regarding Loratadine overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Loratadine Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Loratadine Mechanism of Action in the drug label.

Structure

There is limited information regarding Loratadine Structure in the drug label.

Pharmacodynamics

There is limited information regarding Loratadine Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Loratadine Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Loratadine Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Loratadine Clinical Studies in the drug label.

How Supplied

There is limited information regarding Loratadine How Supplied in the drug label.

Storage

There is limited information regarding Loratadine Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Loratadine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Loratadine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Loratadine Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Loratadine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Loratadine Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Loratadine Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Menardo JL, Horak F, Danzig MR, Czarlewski W (1997). "A review of loratadine in the treatment of patients with allergic bronchial asthma". Clin Ther. 19 (6): 1278–93, discussion 1523-4. PMID 9444440.
  2. ↑ Corren J, Harris AG, Aaronson D, Beaucher W, Berkowitz R, Bronsky E; et al. (1997). "Efficacy and safety of loratadine plus pseudoephedrine in patients with seasonal allergic rhinitis and mild asthma". J Allergy Clin Immunol. 100 (6 Pt 1): 781–8. PMID 9438487.

Synonyms / Brand Names:

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]

Dosing and Administration



FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.

Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.

Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.

Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information

Trial Resources
Ongoing Trials, Trial Results

Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.

Media Resources
Slides, Video, Images, MP3, Podcasts, etc.

Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.

International Resources
en Español





FDA Package Insert Resources

Indications

Contraindications

Side Effects

Drug Interactions

Precautions

Overdose

Instructions for Administration

How Supplied

Pharmacokinetics and Molecular Data

FDA label

FDA on Loratadine

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Publication Resources

Most Recent Articles on Loratadine

Review Articles on Loratadine

Articles on Loratadine in N Eng J Med, Lancet, BMJ

WikiDoc State of the Art Review

Textbook Information on Loratadine

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Trial Resources

Ongoing Trials with Loratadine at Clinical Trials.gov

Trial Results with Loratadine

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Guidelines & Evidence Based Medicine Resources

US National Guidelines Clearinghouse on Loratadine

Cochrane Collaboration on Loratadine

Cost Effectiveness of Loratadine

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Media Resources

Powerpoint Slides on Loratadine

Images of Loratadine

Podcasts & MP3s on Loratadine

Videos on Loratadine

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Patient Resources

Patient Information from National Library of Medicine

Patient Resources on Loratadine

Discussion Groups on Loratadine

Patient Handouts on Loratadine

Blogs on Loratadine

Loratadine in the News

Loratadine in the Marketplace

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International Resources

Loratadine en Español

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Adapted from the FDA Package Insert.

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