'''Doxycycline''' ([[International Phonetic Alphabet|IPA]] is a [[tetracycline antibiotic]] which is commonly used to treat a variety of [[infection]]s. Doxycycline product received Food and Drug Administration (United States)|US Food and Drug Administration approval in 1967.<ref name=PackageInsert>{{cite web|title=Vibramycin. HUMAN PRESCRIPTION DRUG LABEL|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d6f98d3c-5a20-4cbf-9a9c-abef10b9e465#nlm34089-3|work=DailyMed|publisher=U.S. National Library of Medicine|accessdate=3 October 2013}}</ref> Other brand names include Monodox, Microdox, Periostat, Vibra-Tabs, Oracea, Doryx,<ref>{{cite news| url=http://www.bloomberg.com/news/2012-04-30/mylan-impax-win-ruling-in-doryx-generics-patent-case.html | work=Bloomberg | first1=David | last1=Voreacos | first2=Susan | last2=Decker | title=Mylan, Impax Win Ruling in Doryx Generics Patent Case | date=30 April 2012}}</ref> Vibrox, Adoxa, Doxyhexal, Doxylin, Doxoral, Doxy-1 and Atridox (topical doxycycline hyclate for [[periodontitis]]).
'''| [[Doxycycline hyclate dosage and administration|Dosage and Administration]]'''
'''| [[Doxycycline hyclate how supplied|How Supplied]]'''
'''| [[Doxycycline hyclate labels and packages|Labels and Packages]]'''
==Mechanism of Action==
|aOrAn=
Doxycycline is primarily bacteriostatic and thought to exert its antimicrobial effect by the inhibition of protein synthesis. it acts by binding to the [[30S]] and [[50S]] ribosomal subunits, which impairs protein synthesis by bacteria. Doxycycline is active against a wide range of gram-positive and gram-negative organisms.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DOXY 100 (DOXYCYCLINE) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [APP PHARMACEUTICALS, LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b0894010-39bd-459f-8563-cf83343105ee | publisher = | date = | accessdate}}</ref>
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Black Box Warning
Title
See full prescribing information for complete Boxed Warning.
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Content
Overview
Doxycycline (oral) is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
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Dosing Information
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Dosing Information
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Condition3
Dosing Information
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Condition4
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Off-Label Use and Dosage (Adult)
Guideline-Supported Use
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Developed by:
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Strength of Evidence:
Dosing Information
Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Doxycycline (oral) in adult patients.
Non–Guideline-Supported Use
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Dosing Information
Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Doxycycline (oral) in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Condition1
Dosing Information
Dosage
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There is limited information regarding FDA-Labeled Use of Doxycycline (oral) in pediatric patients.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
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Developed by:
Class of Recommendation:
Strength of Evidence:
Dosing Information
Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Doxycycline (oral) in pediatric patients.
Non–Guideline-Supported Use
Condition1
Dosing Information
Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Doxycycline (oral) in pediatric patients.
Contraindications
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Warnings
Title
See full prescribing information for complete Boxed Warning.
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Content
Description
Precautions
Description
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Doxycycline (oral) in the drug label.
Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Doxycycline (oral) in the drug label.