West nile virus causes: Difference between revisions

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WNV is a member of Japanese encephalitis serocomplex and belongs to the [[genus]] [[Flavivirus]], family [[Flaviviridae]].  Other [[species]] of the this serocomplex include the [[St Louis encephalitis virus]] and the [[Japanese encephalitis virus]].<ref name="pmid23860989">{{cite journal| author=Petersen LR, Brault AC, Nasci RS| title=West Nile virus: review of the literature. | journal=JAMA | year= 2013 | volume= 310 | issue= 3 | pages= 308-15 | pmid=23860989 | doi=10.1001/jama.2013.8042 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23860989  }} </ref>  
WNV is a member of Japanese encephalitis serocomplex and belongs to the [[genus]] [[Flavivirus]], family [[Flaviviridae]].  Other [[species]] of the this serocomplex include the [[St Louis encephalitis virus]] and the [[Japanese encephalitis virus]].<ref name="pmid23860989">{{cite journal| author=Petersen LR, Brault AC, Nasci RS| title=West Nile virus: review of the literature. | journal=JAMA | year= 2013 | volume= 310 | issue= 3 | pages= 308-15 | pmid=23860989 | doi=10.1001/jama.2013.8042 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23860989  }} </ref>  


The WNV has an icosahedral symmetry, with a smooth surface.<ref name="Mukhopadhyay2003">{{cite journal|last1=Mukhopadhyay|first1=S.|title=Structure of West Nile Virus|journal=Science|volume=302|issue=5643|year=2003|pages=248–248|issn=0036-8075|doi=10.1126/science.1089316}}</ref>  It is an enveloped virus with a nucleocapsid core built of [[RNA]] and [[capsid]] proteins.  Its [[genome]] is contained in a single-stranded [[RNA]] of about 11000 bp.<ref name="CampbellMarfin2002">{{cite journal|last1=Campbell|first1=Grant L|last2=Marfin|first2=Anthony A|last3=Lanciotti|first3=Robert S|last4=Gubler|first4=Duane J|title=West Nile virus|journal=The Lancet Infectious Diseases|volume=2|issue=9|year=2002|pages=519–529|issn=14733099|doi=10.1016/S1473-3099(02)00368-7}}</ref>  It contains a single open reading frame ([[ORF]]), a 5' untranslated region ([[UTR]]), and another 3' region which is also not translated. The ORF contains a single polyprotein, that after processed and translated produces 3 smaller types of structure proteins and 7 of non-structural proteins.
The WNV has an icosahedral symmetry, with a smooth surface.<ref name="Mukhopadhyay2003">{{cite journal|last1=Mukhopadhyay|first1=S.|title=Structure of West Nile Virus|journal=Science|volume=302|issue=5643|year=2003|pages=248–248|issn=0036-8075|doi=10.1126/science.1089316}}</ref>  It is an enveloped virus with a nucleocapsid core built of [[RNA]] and [[capsid]] proteins.  Its [[genome]] is contained in a single-stranded [[RNA]] of about 11000 bp.<ref name="CampbellMarfin2002">{{cite journal|last1=Campbell|first1=Grant L|last2=Marfin|first2=Anthony A|last3=Lanciotti|first3=Robert S|last4=Gubler|first4=Duane J|title=West Nile virus|journal=The Lancet Infectious Diseases|volume=2|issue=9|year=2002|pages=519–529|issn=14733099|doi=10.1016/S1473-3099(02)00368-7}}</ref>  It contains a single open reading frame ([[ORF]]), a 5' untranslated region ([[UTR]]), and another 3' region which is also not translated. The ORF contains a single polyprotein that produces 3 smaller types of structure proteins and 7 of non-structural proteins following processing and translation.
* Structural proteins are responsible for the formation of the viral particle and include:
* Structural proteins are responsible for the formation of the viral particle and include:
:* Envelope proteins
:* Envelope proteins

Revision as of 12:46, 12 September 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

WNV is an enveloped positive-sense ssRNA virus of 11000 base pairs (bp) that is considered a member of the Japanese encephalitis serocomplex. It belongs to the genus Flavivirus and family Flaviviridae. Its RNA encodes structural and non-structural proteins. Although 7 lineages of WNV have been described, only lineage 1 and 2 are clinically significant. The viral natural reservoir includes many species, such as humans, horses, dogs, and cats; but the main natural reservoir is birds.

Taxonomy

Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Flavivirus; Japanese encephalitis virus group[1]

Biology

Digitally-colorized transmission electron micrograph (TEM) of the West Nile virus (WNV). Image provided by the CDC Centers for Disease Control and Prevention [2]
Presence of West Nile virus virions, in an isolate that was grown in a cell culture. Image provided by the CDC Centers for Disease Control and Prevention [3]

WNV is a member of Japanese encephalitis serocomplex and belongs to the genus Flavivirus, family Flaviviridae. Other species of the this serocomplex include the St Louis encephalitis virus and the Japanese encephalitis virus.[4]

The WNV has an icosahedral symmetry, with a smooth surface.[5] It is an enveloped virus with a nucleocapsid core built of RNA and capsid proteins. Its genome is contained in a single-stranded RNA of about 11000 bp.[6] It contains a single open reading frame (ORF), a 5' untranslated region (UTR), and another 3' region which is also not translated. The ORF contains a single polyprotein that produces 3 smaller types of structure proteins and 7 of non-structural proteins following processing and translation.

  • Structural proteins are responsible for the formation of the viral particle and include:
  • Envelope proteins
  • Membrane proteins
  • C proteins
  • Non-structural proteins are responsible for viral replication, evasion of the immune system, and assembly of virions, and include:
  • NS1
  • NS2A
  • NS2B
  • NS3
  • NS4A
  • NS4B
  • NS5

The WNV may be classified in 7 phylogenetic lineages. Of these, only 1 and 2 have been identified as causative agents of disease in humans and are considered clinically significant.[7] Lineage 1 may be subclassified into 3 other lineages, which predominate in certain parts of the world:[8][9][10][11][12][13][14]

  • Lineage 1: Widespread, isolates from Europe, America, Middle East, India, Africa, and Australia
  • Lingeage 2: Southern Africa, Madagascar, and Europe

Natural reservoir

Although WNV can infect humans and numerous animals, birds are its main natural reservoir.[4][6]

References

  1. ↑ "West Nile Virus".
  2. ↑ "http://phil.cdc.gov/phil/details.asp". External link in |title= (help)
  3. ↑ "http://phil.cdc.gov/phil/details.asp". External link in |title= (help)
  4. ↑ 4.0 4.1 Petersen LR, Brault AC, Nasci RS (2013). "West Nile virus: review of the literature". JAMA. 310 (3): 308–15. doi:10.1001/jama.2013.8042. PMID 23860989.
  5. ↑ Mukhopadhyay, S. (2003). "Structure of West Nile Virus". Science. 302 (5643): 248–248. doi:10.1126/science.1089316. ISSN 0036-8075.
  6. ↑ 6.0 6.1 Campbell, Grant L; Marfin, Anthony A; Lanciotti, Robert S; Gubler, Duane J (2002). "West Nile virus". The Lancet Infectious Diseases. 2 (9): 519–529. doi:10.1016/S1473-3099(02)00368-7. ISSN 1473-3099.
  7. ↑ "West Nile Virus" (PDF).
  8. ↑ Miller DL, Mauel MJ, Baldwin C, Burtle G, Ingram D, Hines ME; et al. (2003). "West Nile virus in farmed alligators". Emerg Infect Dis. 9 (7): 794–9. doi:10.3201/eid0907.030085. PMC 3023431. PMID 12890319.
  9. ↑ Bakonyi T, Ivanics E, Erdélyi K, Ursu K, Ferenczi E, Weissenböck H; et al. (2006). "Lineage 1 and 2 strains of encephalitic West Nile virus, central Europe". Emerg Infect Dis. 12 (4): 618–23. doi:10.3201/eid1204.051379. PMC 3294705. PMID 16704810.
  10. ↑ Charrel RN, Brault AC, Gallian P, Lemasson JJ, Murgue B, Murri S; et al. (2003). "Evolutionary relationship between Old World West Nile virus strains. Evidence for viral gene flow between Africa, the Middle East, and Europe". Virology. 315 (2): 381–8. PMID 14585341.
  11. ↑ Lanciotti RS, Ebel GD, Deubel V, Kerst AJ, Murri S, Meyer R; et al. (2002). "Complete genome sequences and phylogenetic analysis of West Nile virus strains isolated from the United States, Europe, and the Middle East". Virology. 298 (1): 96–105. PMID 12093177.
  12. ↑ Papa A, Xanthopoulou K, Gewehr S, Mourelatos S (2011). "Detection of West Nile virus lineage 2 in mosquitoes during a human outbreak in Greece". Clin Microbiol Infect. 17 (8): 1176–80. doi:10.1111/j.1469-0691.2010.03438.x. PMID 21781205.
  13. ↑ Savini G, Capelli G, Monaco F, Polci A, Russo F, Di Gennaro A; et al. (2012). "Evidence of West Nile virus lineage 2 circulation in Northern Italy". Vet Microbiol. 158 (3–4): 267–73. doi:10.1016/j.vetmic.2012.02.018. PMID 22406344.
  14. ↑ Valiakos G, Touloudi A, Iacovakis C, Athanasiou L, Birtsas P, Spyrou V; et al. (2011). "Molecular detection and phylogenetic analysis of West Nile virus lineage 2 in sedentary wild birds (Eurasian magpie), Greece, 2010". Euro Surveill. 16 (18). PMID 21586266.
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