Creutzfeldt-Jakob disease laboratory findings: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
No edit summary
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{‪Creutzfeldt-Jakob disease‬}}
{{‪Creutzfeldt-Jakob disease‬}}
Please help WikiDoc by adding more content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
{{CMG}}


{{CMG}}
==Overview==
==Overview==
The diagnosis of CJD is suspected when there are typical clinical symptoms and signs such as rapidly progressing [[dementia]] with [[myoclonus]]. Analysis of CSF for [[14-3-3 protein]] is done to establish probable diagnosis.  Positive 14-3-3 protein in CSF analysis makes the diagnosis of CJD probable but it is not diagnostic of CJD.<ref name="Muayqil-2012">{{Cite journal  | last1 = Muayqil | first1 = T. | last2 = Gronseth | first2 = G. | last3 = Camicioli | first3 = R. | title = Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology. | journal = Neurology | volume = 79 | issue = 14 | pages = 1499-506 | month = Oct | year = 2012 | doi = 10.1212/WNL.0b013e31826d5fc3 | PMID = 22993290 }}</ref>
Routine laboratory tests are usually normal in Creutzfeldt Jakob disease. Analysis of CSF for [[14-3-3 protein]] may be helpful in the diagnosis of Creutzfeldt-Jakob disease‬.<ref name="Muayqil-2012">{{Cite journal  | last1 = Muayqil | first1 = T. | last2 = Gronseth | first2 = G. | last3 = Camicioli | first3 = R. | title = Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology. | journal = Neurology | volume = 79 | issue = 14 | pages = 1499-506 | month = Oct | year = 2012 | doi = 10.1212/WNL.0b013e31826d5fc3 | PMID = 22993290 }}</ref> Other elevated proteins in CSF may include S-100, neuron specific enolase, and Tau protein.
==Laboratory Tests==
==Laboratory Tests==
* Routine laboratory tests are normal in Creutzfeldt Jakob disease. [[Liver function tests]] could be abnormal in some cases.<ref name="Tanaka-1992">{{Cite journal  | last1 = Tanaka | first1 = M. | last2 = Iizuka | first2 = O. | last3 = Yuasa | first3 = T. | title = Hepatic dysfunction in Creutzfeldt-Jakob disease. | journal = Neurology | volume = 42 | issue = 6 | pages = 1249 | month = Jun | year = 1992 | doi =  | PMID = 1302460 }}</ref>
* Routine laboratory tests are usually normal in Creutzfeldt Jakob disease.
* Presence of following protein markers in addition to 14-3-3 (in [[CSF]]) has also been associated with CJD:
*[[Liver function tests]] may occasionally be elevated.<ref name="Tanaka-1992">{{Cite journal  | last1 = Tanaka | first1 = M. | last2 = Iizuka | first2 = O. | last3 = Yuasa | first3 = T. | title = Hepatic dysfunction in Creutzfeldt-Jakob disease. | journal = Neurology | volume = 42 | issue = 6 | pages = 1249 | month = Jun | year = 1992 | doi =  | PMID = 1302460 }}</ref>
*:* S-100
* In CSF, elevated concentrations of following protein markers may be remarkable in Creutzfeldt-Jakob disease‬:<ref name="Sanchez-Juan-2006">{{Cite journal  | last1 = Sanchez-Juan | first1 = P. | last2 = Green | first2 = A. | last3 = Ladogana | first3 = A. | last4 = Cuadrado-Corrales | first4 = N. | last5 = Sáanchez-Valle | first5 = R. | last6 = Mitrováa | first6 = E. | last7 = Stoeck | first7 = K. | last8 = Sklaviadis | first8 = T. | last9 = Kulczycki | first9 = J. | title = CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease. | journal = Neurology | volume = 67 | issue = 4 | pages = 637-43 | month = Aug | year = 2006 | doi = 10.1212/01.wnl.0000230159.67128.00 | PMID = 16924018 }}</ref>
*:* Neuron specific enolase
:* 14-3-3 protein
*:* [[Tau protein]]<ref name="Sanchez-Juan-2006">{{Cite journal  | last1 = Sanchez-Juan | first1 = P. | last2 = Green | first2 = A. | last3 = Ladogana | first3 = A. | last4 = Cuadrado-Corrales | first4 = N. | last5 = Sáanchez-Valle | first5 = R. | last6 = Mitrováa | first6 = E. | last7 = Stoeck | first7 = K. | last8 = Sklaviadis | first8 = T. | last9 = Kulczycki | first9 = J. | title = CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease. | journal = Neurology | volume = 67 | issue = 4 | pages = 637-43 | month = Aug | year = 2006 | doi = 10.1212/01.wnl.0000230159.67128.00 | PMID = 16924018 }}</ref>
:* S-100
:* Neuron specific enolase
:* [[Tau protein]]


==References==
==References==
Line 23: Line 24:
[[Category:Disease]]
[[Category:Disease]]
[[Category:Transmissible spongiform encephalopathies]]
[[Category:Transmissible spongiform encephalopathies]]
[[Category:Needs content]]

Revision as of 20:12, 22 March 2016

Creutzfeldt-Jakob disease Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Creutzfeldt-Jakob disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Creutzfeldt-Jakob disease laboratory findings On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Creutzfeldt-Jakob disease laboratory findings

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Creutzfeldt-Jakob disease laboratory findings

CDC on Creutzfeldt-Jakob disease laboratory findings

Creutzfeldt-Jakob disease laboratory findings in the news

Blogs on Creutzfeldt-Jakob disease laboratory findings

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Creutzfeldt-Jakob disease laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Routine laboratory tests are usually normal in Creutzfeldt Jakob disease. Analysis of CSF for 14-3-3 protein may be helpful in the diagnosis of Creutzfeldt-Jakob disease‬.[1] Other elevated proteins in CSF may include S-100, neuron specific enolase, and Tau protein.

Laboratory Tests

  • Routine laboratory tests are usually normal in Creutzfeldt Jakob disease.
  • Liver function tests may occasionally be elevated.[2]
  • In CSF, elevated concentrations of following protein markers may be remarkable in Creutzfeldt-Jakob disease‬:[3]
  • 14-3-3 protein
  • S-100
  • Neuron specific enolase
  • Tau protein

References

  1. ↑ Muayqil, T.; Gronseth, G.; Camicioli, R. (2012). "Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology". Neurology. 79 (14): 1499–506. doi:10.1212/WNL.0b013e31826d5fc3. PMID 22993290. Unknown parameter |month= ignored (help)
  2. ↑ Tanaka, M.; Iizuka, O.; Yuasa, T. (1992). "Hepatic dysfunction in Creutzfeldt-Jakob disease". Neurology. 42 (6): 1249. PMID 1302460. Unknown parameter |month= ignored (help)
  3. ↑ Sanchez-Juan, P.; Green, A.; Ladogana, A.; Cuadrado-Corrales, N.; Sáanchez-Valle, R.; Mitrováa, E.; Stoeck, K.; Sklaviadis, T.; Kulczycki, J. (2006). "CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease". Neurology. 67 (4): 637–43. doi:10.1212/01.wnl.0000230159.67128.00. PMID 16924018. Unknown parameter |month= ignored (help)


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Creutzfeldt-Jakob_disease_laboratory_findings&oldid=1228051"