Creutzfeldt-Jakob disease historical perspective: Difference between revisions

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==Overview==
==Overview==
Creutzfeldt Jakob disease was first coined by Spielmeyer in 1922 to describe cases of rapidly progressive dementia reported by Creutzfeldt in 1920 and Jakob in 1921.<ref name="McKintosh-2003">{{Cite journal  | last1 = McKintosh | first1 = E. | last2 = Tabrizi | first2 = SJ. | last3 = Collinge | first3 = J. | title = Prion diseases. | journal = J Neurovirol | volume = 9 | issue = 2 | pages = 183-93 | month = Apr | year = 2003 | doi = 10.1080/13550280390194082 | PMID = 12707849 }}</ref>
Creutzfeldt Jakob disease was first described in 1920-1921 by two German [[neurologist]]s, [[Hans Gerhard Creutzfeldt]] and [[Alfons Maria Jakob]].


==Historical Perspective==
==Historical Perspective==
* The disease was first described by two German [[neurologist]]s, [[Hans Gerhard Creutzfeldt]] and [[Alfons Maria Jakob]]. Some of the clinical findings described in their first papers do not match current criteria for Creutzfeldt-Jakob disease, and it is considered highly likely that at least two of the patients in initial studies were suffering from a different disorder.
*Creutzfeldt Jakob disease was first described in 1920-1921 by two German [[neurologist]]s, [[Hans Gerhard Creutzfeldt]] and [[Alfons Maria Jakob]].
 
*The term ''Creutzfeldt Jakob'' was first coined by Spielmeyer in 1922 in honor of Creutzfeldt and Jakob's report.<ref name="McKintosh-2003">{{Cite journal  | last1 = McKintosh | first1 = E. | last2 = Tabrizi | first2 = SJ. | last3 = Collinge | first3 = J. | title = Prion diseases. | journal = J Neurovirol | volume = 9 | issue = 2 | pages = 183-93 | month = Apr | year = 2003 | doi = 10.1080/13550280390194082 | PMID = 12707849 }}</ref>
* [[Stanley B. Prusiner]] was awarded the [[Nobel Prize in physiology or medicine]] in 1997 for his discovery of [[prion]]s. For more than a decade, Yale University [[neuropathologist]] [[Laura Manuelidis]] has been challenging this explanation for the disease.  In January 2007 she and her colleagues published an article in the [[Proceedings of the National Academy of Science]] and reported that they have found a [[virus]]-like particle (but without finding [[nucleic acid]]s so far) in less than 10% of the cells a scrapie-infected cell line and in a mouse cell line infected by a human CJD agent.<ref name="Manuelidis2007">{{cite journal| author=Manuelidis L| coauthors=Yu ZX, Barquero N, Mullins B|date=February 6, 2007| title=Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles| journal=Proceedings of the National Academy of Science| volume=104| issue=6| pages=1975-1970| pmid=17267596|url=http://www.pnas.org/cgi/content/full/104/6/1965| accessdate=2007-09-24}}</ref>
* In 1997, [[Stanley B. Prusiner]] was awarded the Nobel Prize in physiology or medicine for his discovery of [[prion]]s.  
*In 2007, Laura Manuelidis, an American neuropathologist, and her colleagues described a [[virus]]-like particle without nucleic acid in less than 10% of the cells a scrapie-infected cell line and in a mouse cell line infected by a human Creutzfeldt Jakob disease agent.<ref name="Manuelidis2007">{{cite journal| author=Manuelidis L| coauthors=Yu ZX, Barquero N, Mullins B|date=February 6, 2007| title=Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles| journal=Proceedings of the National Academy of Science| volume=104| issue=6| pages=1975-1970| pmid=17267596|url=http://www.pnas.org/cgi/content/full/104/6/1965| accessdate=2007-09-24}}</ref>


==References==
==References==
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[[Category:Disease]]
[[Category:Disease]]
[[Category:Transmissible spongiform encephalopathies]]
[[Category:Transmissible spongiform encephalopathies]]
[[Category:Needs overview]]

Revision as of 19:29, 17 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Creutzfeldt Jakob disease was first described in 1920-1921 by two German neurologists, Hans Gerhard Creutzfeldt and Alfons Maria Jakob.

Historical Perspective

  • Creutzfeldt Jakob disease was first described in 1920-1921 by two German neurologists, Hans Gerhard Creutzfeldt and Alfons Maria Jakob.
  • The term Creutzfeldt Jakob was first coined by Spielmeyer in 1922 in honor of Creutzfeldt and Jakob's report.[1]
  • In 1997, Stanley B. Prusiner was awarded the Nobel Prize in physiology or medicine for his discovery of prions.
  • In 2007, Laura Manuelidis, an American neuropathologist, and her colleagues described a virus-like particle without nucleic acid in less than 10% of the cells a scrapie-infected cell line and in a mouse cell line infected by a human Creutzfeldt Jakob disease agent.[2]

References

  1. McKintosh, E.; Tabrizi, SJ.; Collinge, J. (2003). "Prion diseases". J Neurovirol. 9 (2): 183–93. doi:10.1080/13550280390194082. PMID 12707849. Unknown parameter |month= ignored (help)
  2. Manuelidis L (February 6, 2007). "Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles". Proceedings of the National Academy of Science. 104 (6): 1975–1970. PMID 17267596. Retrieved 2007-09-24. Unknown parameter |coauthors= ignored (help)


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