Hyperlipidemia NCEP recommendations for drug therapy of high-risk hyperlipidemia in children and adolescents: Difference between revisions
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===Original Recommendations of the National Cholesterol Education Program (NCEP) Expert Panel for Drug Therapy of High-Risk Hyperlipidemia in Children and Adolescents <ref name="pmid17377073">{{cite journal| author=McCrindle BW, Urbina EM, Dennison BA, Jacobson MS, Steinberger J, Rocchini AP et al.| title=Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. | journal=Circulation | year= 2007 | volume= 115 | issue= 14 | pages= 1948-67 | pmid=17377073 | doi=10.1161/CIRCULATIONAHA.107.181946 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17377073 }} </ref> (DO NOT EDIT)=== | ===Original Recommendations of the National Cholesterol Education Program (NCEP) Expert Panel for Drug Therapy of High-Risk Hyperlipidemia in Children and Adolescents <ref name="pmid17377073">{{cite journal| author=McCrindle BW, Urbina EM, Dennison BA, Jacobson MS, Steinberger J, Rocchini AP et al.| title=Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. | journal=Circulation | year= 2007 | volume= 115 | issue= 14 | pages= 1948-67 | pmid=17377073 | doi=10.1161/CIRCULATIONAHA.107.181946 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17377073 }} </ref> (DO NOT EDIT)=== | ||
* Consider drug therapy in '''children | {{cquote| | ||
* Consider drug therapy in '''children ≥10 years of age''' (usually wait until [[menarche]] for females) and after a '''6- to 12-month trial of fat- and cholesterol-restricted dietary management'''. | |||
* Consider drug therapy if | * Consider drug therapy if | ||
** [[LDL]] level remains ''' | ** [[LDL]] level remains '''≥4.90 mmol/L (190 mg/dL)''' or | ||
** [[LDL]] remains '''>4.10 mmol/L (160 mg/dL)''' and there is a positive family history of '''premature cardiovascular disease''' or | ** [[LDL]] remains '''>4.10 mmol/L (160 mg/dL)''' and there is a positive family history of '''premature cardiovascular disease''' or ≥2 other risk factors are present in the child or adolescent after vigorous attempts to control these risk factors. | ||
* Referral to specialized lipid center may be deemed appropriate. | * Referral to specialized lipid center may be deemed appropriate. | ||
* '''Treatment goal''' | * '''Treatment goal''' | ||
** Minimal, LDL '''<3.35 mmol/L (130 mg/dL)''' | ** Minimal, LDL '''<3.35 mmol/L (130 mg/dL)''' | ||
** Ideal, LDL '''<2.85 mmol/L (110 mg/dL)''' | ** Ideal, LDL '''<2.85 mmol/L (110 mg/dL)''' | ||
}} | |||
===Current Modification of the National Cholesterol Education Program (NCEP) Expert Panel for Drug Therapy of High-Risk Hyperlipidemia in Children and Adolescents <ref name="pmid17377073">{{cite journal| author=McCrindle BW, Urbina EM, Dennison BA, Jacobson MS, Steinberger J, Rocchini AP et al.| title=Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. | journal=Circulation | year= 2007 | volume= 115 | issue= 14 | pages= 1948-67 | pmid=17377073 | doi=10.1161/CIRCULATIONAHA.107.181946 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17377073 }} </ref> (DO NOT EDIT)=== | ===Current Modification of the National Cholesterol Education Program (NCEP) Expert Panel for Drug Therapy of High-Risk Hyperlipidemia in Children and Adolescents <ref name="pmid17377073">{{cite journal| author=McCrindle BW, Urbina EM, Dennison BA, Jacobson MS, Steinberger J, Rocchini AP et al.| title=Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. | journal=Circulation | year= 2007 | volume= 115 | issue= 14 | pages= 1948-67 | pmid=17377073 | doi=10.1161/CIRCULATIONAHA.107.181946 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17377073 }} </ref> (DO NOT EDIT)=== |
Revision as of 15:49, 26 October 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Children and adolescents with high-risk hyperlipidemia require lipid-lowering drug therapy, particularly those with familial hypercholesterolemia, despite compliance with lifestyle recommendations.
NCEP Recommendations for Drug Therapy of High-Risk Hyperlipidemia in Children and Adolescents
Original Recommendations of the National Cholesterol Education Program (NCEP) Expert Panel for Drug Therapy of High-Risk Hyperlipidemia in Children and Adolescents [1] (DO NOT EDIT)
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Current Modification of the National Cholesterol Education Program (NCEP) Expert Panel for Drug Therapy of High-Risk Hyperlipidemia in Children and Adolescents [1] (DO NOT EDIT)
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References
- ↑ 1.0 1.1 McCrindle BW, Urbina EM, Dennison BA, Jacobson MS, Steinberger J, Rocchini AP; et al. (2007). "Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing". Circulation. 115 (14): 1948–67. doi:10.1161/CIRCULATIONAHA.107.181946. PMID 17377073.