Myleofibrosis: Difference between revisions

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Revision as of 15:38, 21 September 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Myleofibrosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

Case Studies

Case#1

Template:WH Template:WikiDoc Sources

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 {{CMG}}
-'''Primary myelofibrosis''', also known as '''Myelofibrosis'''; '''Idiopathic myelofibrosis'''; '''Myeloid metaplasia'''; '''Agnogenic myeloid metaplasia''', is a disorder of the [[bone marrow]], in which the marrow is replaced by fibrous (scar) tissue ([[collagen]]).
+==[[Myleofibrosis overview|Overview]]==
-== Causes, incidence, and risk factors ==
+==[[Myleofibrosis historical perspective|Historical Perspective]]==
-In primary myelofibrosis, a progressive scarring ([[fibrosis]]) of the bone marrow occurs. As a result, blood forms in sites other than the bone marrow, such as the [[liver]] and [[spleen]]. This causes an enlargement of these organs. The cause and risk factors are unknown.  It commonly occurs in the spent phase of [[Polycythemia Rubra Vera]], possibly in response to the medication [[hydroxyurea]] poisoning the marrow.
-The disorder usually develops slowly, in people over 50 years old. It leads to progressive bone marrow failure with severe [[anemia]]. Low platelet count leads to easy bleeding, and spleen enlargement continues.
+==[[Myleofibrosis classification|Classification]]==
-== Symptoms ==
+==[[Myleofibrosis pathophysiology|Pathophysiology]]==
-*Abdominal fullness related to an enlarged spleen
-*Bone pain
-*Bruising
-*Easy bleeding
-*Fatigue
-*Increased susceptibility to infection
-*Pallor
-*Shortness of breath while doing physical work
-*Uncontrollable [[diarrhea]]
-== Treatment ==
+==[[Myleofibrosis causes|Causes]]==
-Myleofibrosis has no known cure.  [[Lenalidomide]] (brand name Revlimid) and [[Thalidomide]] are drugs that can be used in its treatment, though they can cause [[gout]] and leave the patient susceptible to diseases such as [[pneumonia]].  Frequent [[blood transfusions]] may also be required.
+==[[Myleofibrosis differential diagnosis|Differentiating Myleofibrosis from other Diseases]]==
-{{SIB}}
+==[[Myleofibrosis epidemiology and demographics|Epidemiology and Demographics]]==
+==[[Myleofibrosis risk factors|Risk Factors]]==
+==[[Myleofibrosis screening|Screening]]==
+==[[Myleofibrosis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
+==Diagnosis==
+[[Myleofibrosis history and symptoms| History and Symptoms]] | [[Myleofibrosis physical examination | Physical Examination]] |[[Myleofibrosis laboratory findings|Laboratory Findings]] | [[Myleofibrosis x ray|X Ray]] |  [[MyleofibrosisCT|CT]] | [[Myleofibrosis MRI|MRI]] | [[Myleofibrosis ultrasound|Ultrasound]] | [[Myleofibrosis other imaging findings|Other Imaging Findings]] | [[Myleofibrosis other diagnostic studies|Other Diagnostic Studies]]
+==Treatment==
+[[Myleofibrosis medical therapy|Medical Therapy]] | [[Myleofibrosis surgery|Surgery]] | [[Myleofibrosis primary prevention|Primary Prevention]] | [[Myleofibrosis secondary prevention|Secondary Prevention]] | [[Myleofibrosis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Myleofibrosisfuture or investigational therapies|Future or Investigational Therapies]]
+==Case Studies==
+[[Myleofibrosis case study one|Case#1]]
 [[Category:Hematology]]
 {{WH}}
 {{WikiDoc Sources}}

Myleofibrosis: Difference between revisions

Revision as of 15:38, 21 September 2012

Diagnosis

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