PLA2G4C: Difference between revisions

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(+OA URL https://zenodo.org/record/1042399)
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{{Underlinked|date=February 2013}}
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{{Infobox_gene}}
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'''Cytosolic phospholipase A2 gamma''' is an [[enzyme]] that in humans is encoded by the ''PLA2G4C'' [[gene]].<ref name="pmid9705332">{{cite journal |vauthors=Underwood KW, Song C, Kriz RW, Chang XJ, Knopf JL, Lin LL | title = A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2 | journal = J Biol Chem | volume = 273 | issue = 34 | pages = 21926–32 |date=Sep 1998 | pmid = 9705332 | pmc =  | doi =10.1074/jbc.273.34.21926 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8605| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Phospholipase A2, group IVC (cytosolic, calcium-independent)
| HGNCid = 9037
| Symbol = PLA2G4C
| AltSymbols =; CPLA2-gamma; DKFZp586C0423
| OMIM = 603602
| ECnumber = 
| Homologene = 2748
| MGIid = 1196403
| GeneAtlas_image1 = PBB_GE_PLA2G4C_209785_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005543 |text = phospholipid binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0047499 |text = calcium-independent phospholipase A2 activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007567 |text = parturition}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}} {{GNF_GO|id=GO:0019369 |text = arachidonic acid metabolic process}} {{GNF_GO|id=GO:0046475 |text = glycerophospholipid catabolic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8605
    | Hs_Ensembl = ENSG00000105499
    | Hs_RefseqProtein = NP_003697
    | Hs_RefseqmRNA = NM_003706
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 53242916
    | Hs_GenLoc_end = 53305865
    | Hs_Uniprot = Q9UP65
    | Mm_EntrezGene = 232889
    | Mm_Ensembl = ENSMUSG00000033847
    | Mm_RefseqmRNA = NM_001004762
    | Mm_RefseqProtein = NP_001004762
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 12229819
    | Mm_GenLoc_end = 12260122
    | Mm_Uniprot = 
  }}
}}
'''Phospholipase A2, group IVC (cytosolic, calcium-independent)''', also known as '''PLA2G4C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8605| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Schröder HC, Perovic S, Kavsan V, ''et al.'' |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. |journal=Neurotoxicology |volume=19 |issue= 4-5 |pages= 683-8 |year= 1998 |pmid= 9745929 |doi=  }}
*{{cite journal  | author=Schröder HC |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death |journal=Neurotoxicology |volume=19 |issue= 4–5 |pages= 683–8 |year= 1998 |pmid= 9745929 |doi=  |name-list-format=vanc| author2=Perovic S  | author3=Kavsan V  | display-authors=3  | last4=Ushijima  | first4=H  | last5=Müller  | first5=WE }}
*{{cite journal  | author=Wu T, Angus CW, Yao XL, ''et al.'' |title=P11, a unique member of the S100 family of calcium-binding proteins, interacts with and inhibits the activity of the 85-kDa cytosolic phospholipase A2. |journal=J. Biol. Chem. |volume=272 |issue= 27 |pages= 17145-53 |year= 1997 |pmid= 9202034 |doi=  }}
*{{cite journal  | author=Wu T |title=P11, a unique member of the S100 family of calcium-binding proteins, interacts with and inhibits the activity of the 85-kDa cytosolic phospholipase A2 |journal=J. Biol. Chem. |volume=272 |issue= 27 |pages= 17145–53 |year= 1997 |pmid= 9202034 |doi=10.1074/jbc.272.27.17145 |name-list-format=vanc| author2=Angus CW | author3=Yao XL  | display-authors=3  | last4=Logun  | first4=C  | last5=Shelhamer  | first5=JH }}
*{{cite journal  | author=Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, ''et al.'' |title=HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=16 |issue= 1 |pages= 1-9 |year= 1997 |pmid= 9377118 |doi=  }}
*{{cite journal  | author=Mavoungou E |title=HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=16 |issue= 1 |pages= 1–9 |year= 1997 |pmid= 9377118 |doi=  10.1097/00042560-199709010-00001|name-list-format=vanc| author2=Georges-Courbot MC | author3=Poaty-Mavoungou V  | display-authors=3  | last4=Nguyen  | first4=HT  | last5=Yaba  | first5=P  | last6=Delicat  | first6=A  | last7=Georges | first7=AJ  | last8=Russo-Marie  | first8=F }}
*{{cite journal | author=Underwood KW, Song C, Kriz RW, ''et al.'' |title=A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21926-32 |year= 1998 |pmid= 9705332 |doi=  }}
*{{cite journal  |vauthors=Pickard RT, Strifler BA, Kramer RM, Sharp JD |title=Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2 |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8823–31 |year= 1999 |pmid= 10085124 |doi=10.1074/jbc.274.13.8823  }}
*{{cite journal  | author=Pickard RT, Strifler BA, Kramer RM, Sharp JD |title=Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8823-31 |year= 1999 |pmid= 10085124 |doi=  }}
*{{cite journal  | author=Smith JS |title=A transcript map of the chromosome 19q-arm glioma tumor suppressor region |journal=Genomics |volume=64 |issue= 1 |pages= 44–50 |year= 2000 |pmid= 10708517 |doi= 10.1006/geno.1999.6101  |name-list-format=vanc| author2=Tachibana I | author3=Pohl U  | display-authors=3  | last4=Lee  | first4=HK  | last5=Thanarajasingam  | first5=U  | last6=Portier  | first6=BP  | last7=Ueki  | first7=K  | last8=Ramaswamy  | first8=S  | last9=Billings  | first9=SJ }}
*{{cite journal | author=Smith JS, Tachibana I, Pohl U, ''et al.'' |title=A transcript map of the chromosome 19q-arm glioma tumor suppressor region. |journal=Genomics |volume=64 |issue= 1 |pages= 44-50 |year= 2000 |pmid= 10708517 |doi= 10.1006/geno.1999.6101 }}
*{{cite journal  | author=Hartmann C |title=Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas |journal=Brain Pathol. |volume=12 |issue= 2 |pages= 178–82 |year= 2002 |pmid= 11958371 |doi=10.1111/j.1750-3639.2002.tb00432.x |name-list-format=vanc| author2=Johnk L  | author3=Sasaki H  | display-authors=3  | last4=Jenkins  | first4=Robert B. | last5=Louis  | first5=David N.  }}
*{{cite journal | author=Hartmann C, Johnk L, Sasaki H, ''et al.'' |title=Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas. |journal=Brain Pathol. |volume=12 |issue= 2 |pages= 178-82 |year= 2002 |pmid= 11958371 |doi=  }}
*{{cite journal  |vauthors=Stewart A, Ghosh M, Spencer DM, Leslie CC |title=Enzymatic properties of human cytosolic phospholipase A(2)gamma |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29526–36 |year= 2002 |pmid= 12039969 |doi= 10.1074/jbc.M204856200 }}
*{{cite journal  | author=Stewart A, Ghosh M, Spencer DM, Leslie CC |title=Enzymatic properties of human cytosolic phospholipase A(2)gamma. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29526-36 |year= 2002 |pmid= 12039969 |doi= 10.1074/jbc.M204856200 }}
*{{cite journal  |vauthors=Lindbom J, Ljungman AG, Lindahl M, Tagesson C |title=Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma |journal=J. Interferon Cytokine Res. |volume=22 |issue= 9 |pages= 947–55 |year= 2003 |pmid= 12396716 |doi= 10.1089/10799900260286650 }}
*{{cite journal  | author=Lindbom J, Ljungman AG, Lindahl M, Tagesson C |title=Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 9 |pages= 947-55 |year= 2003 |pmid= 12396716 |doi= 10.1089/10799900260286650 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Asai K |title=Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8809–14 |year= 2003 |pmid= 12502717 |doi= 10.1074/jbc.M212117200 |name-list-format=vanc| author2=Hirabayashi T  | author3=Houjou T  | display-authors=3  | last4=Uozumi  | first4=N  | last5=Taguchi  | first5=R  | last6=Shimizu  | first6=T }}
*{{cite journal  | author=Asai K, Hirabayashi T, Houjou T, ''et al.'' |title=Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8809-14 |year= 2003 |pmid= 12502717 |doi= 10.1074/jbc.M212117200 }}
*{{cite journal  | author=Jenkins CM |title=Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis |journal=Biochemistry |volume=42 |issue= 40 |pages= 11798–807 |year= 2004 |pmid= 14529291 |doi= 10.1021/bi034611q  |name-list-format=vanc| author2=Han X | author3=Yang J  | display-authors=3  | last4=Mancuso  | first4=David J. | last5=Sims  | first5=Harold F.  | last6=Muslin  | first6=Anthony J.  | last7=Gross  | first7=Richard W. }}
*{{cite journal | author=Jenkins CM, Han X, Yang J, ''et al.'' |title=Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis. |journal=Biochemistry |volume=42 |issue= 40 |pages= 11798-807 |year= 2004 |pmid= 14529291 |doi= 10.1021/bi034611q }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Dong M |title=Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis |journal=Clin. Cancer Res. |volume=11 |issue= 6 |pages= 2265–71 |year= 2005 |pmid= 15788676 |doi= 10.1158/1078-0432.CCR-04-1079  |name-list-format=vanc| author2=Johnson M  | author3=Rezaie A  | display-authors=3  | last4=Ilsley  | first4=JN  | last5=Nakanishi  | first5=M  | last6=Sanders  | first6=MM  | last7=Forouhar  | first7=F  | last8=Levine  | first8=J  | last9=Montrose  | first9=DC }}
*{{cite journal | author=Dong M, Johnson M, Rezaie A, ''et al.'' |title=Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis. |journal=Clin. Cancer Res. |volume=11 |issue= 6 |pages= 2265-71 |year= 2005 |pmid= 15788676 |doi= 10.1158/1078-0432.CCR-04-1079 }}
*{{cite journal  | author=Yan W |title=The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 26669–79 |year= 2005 |pmid= 15908428 |doi= 10.1074/jbc.M502358200  |name-list-format=vanc| author2=Jenkins CM  | author3=Han X  | display-authors=3  | last4=Mancuso  | first4=DJ  | last5=Sims  | first5=HF  | last6=Yang  | first6=K  | last7=Gross  | first7=RW }}
*{{cite journal  | author=Yan W, Jenkins CM, Han X, ''et al.'' |title=The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling. |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 26669-79 |year= 2005 |pmid= 15908428 |doi= 10.1074/jbc.M502358200 }}
*{{cite journal  | author=Yamashita A |title=Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma) |journal=J. Biochem. |volume=137 |issue= 5 |pages= 557–67 |year= 2005 |pmid= 15944408 |doi= 10.1093/jb/mvi067 |url=https://zenodo.org/record/1042399  |name-list-format=vanc| author2=Kamata R  | author3=Kawagishi N  | display-authors=3  | last4=Nakanishi  | first4=H  | last5=Suzuki  | first5=H  | last6=Sugiura  | first6=T  | last7=Waku  | first7=K }}
*{{cite journal | author=Yamashita A, Kamata R, Kawagishi N, ''et al.'' |title=Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma). |journal=J. Biochem. |volume=137 |issue= 5 |pages= 557-67 |year= 2005 |pmid= 15944408 |doi= 10.1093/jb/mvi067 }}
*{{cite journal  | author=Zhao X |title=Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 29357–68 |year= 2006 |pmid= 16882668 |doi= 10.1074/jbc.M513105200  |name-list-format=vanc| author2=Wang D  | author3=Zhao Z  | display-authors=3  | last4=Xiao  | first4=Y  | last5=Sengupta  | first5=S  | last6=Xiao  | first6=Y  | last7=Zhang  | first7=R  | last8=Lauber  | first8=K  | last9=Wesselborg  | first9=S }}
*{{cite journal  | author=Zhao X, Wang D, Zhao Z, ''et al.'' |title=Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells. |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 29357-68 |year= 2006 |pmid= 16882668 |doi= 10.1074/jbc.M513105200 }}
*{{cite journal  | author=Mancuso DJ, Han X, Jenkins CM, ''et al.'' |title=Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. |journal=J. Biol. Chem. |volume=282 |issue= 12 |pages= 9216-27 |year= 2007 |pmid= 17213206 |doi= 10.1074/jbc.M607307200 }}
}}
}}
{{refend}}


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Revision as of 11:00, 6 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cytosolic phospholipase A2 gamma is an enzyme that in humans is encoded by the PLA2G4C gene.[1][2]


References

  1. ↑ Underwood KW, Song C, Kriz RW, Chang XJ, Knopf JL, Lin LL (Sep 1998). "A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2". J Biol Chem. 273 (34): 21926–32. doi:10.1074/jbc.273.34.21926. PMID 9705332.
  2. ↑ "Entrez Gene: PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)".

Further reading



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