PDXK: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Underlinked|date=March 2014}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Pyridoxal kinase''' is an [[enzyme]] that in humans is encoded by the ''PDXK'' [[gene]].<ref name="pmid9099727">{{cite journal |vauthors=Hanna MC, Turner AJ, Kirkness EF | title = Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor | journal = J Biol Chem | volume = 272 | issue = 16 | pages = 10756–60 |date=May 1997 | pmid = 9099727 | pmc =  | doi =10.1074/jbc.272.16.10756 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDXK pyridoxal (pyridoxine, vitamin B<sub>6</sub>) kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8566| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PDXK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ajp.
| PDB = {{PDB2|2ajp}}, {{PDB2|2f7k}}
| Name = Pyridoxal (pyridoxine, vitamin B6) kinase
| HGNCid = 8819
| Symbol = PDXK
| AltSymbols =; C21orf97; PKH; PNK
| OMIM = 179020
| ECnumber =
| Homologene = 2731
| MGIid = 1351869
  | GeneAtlas_image1 = PBB_GE_PDXK_202671_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PDXK_218018_at_tn.png
| GeneAtlas_image3 = PBB_GE_PDXK_218019_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008478 |text = pyridoxal kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8566
    | Hs_Ensembl = ENSG00000160209
    | Hs_RefseqProtein = NP_003672
    | Hs_RefseqmRNA = NM_003681
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 43963406
    | Hs_GenLoc_end = 44006608
    | Hs_Uniprot = O00764
    | Mm_EntrezGene = 216134
    | Mm_Ensembl = ENSMUSG00000032788
    | Mm_RefseqmRNA = NM_172134
    | Mm_RefseqProtein = NP_742146
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 77842083
    | Mm_GenLoc_end = 77868104
    | Mm_Uniprot = Q8K183
  }}
}}
'''Pyridoxal (pyridoxine, vitamin B6) kinase''', also known as '''PDXK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDXK pyridoxal (pyridoxine, vitamin B6) kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8566| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: PDXK pyridoxal (pyridoxine, vitamin B6) kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8566| accessdate = }}</ref>
| summary_text = The protein encoded by this gene phosphorylates vitamin B<sub>6</sub>, a step required for the conversion of vitamin B<sub>6</sub> to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chern CJ, Beutler E |title=Biochemical and electrophoretic studies of erythrocyte pyridoxine kinase in white and black Americans. |journal=Am. J. Hum. Genet. |volume=28 |issue= 01 |pages= 9-17 |year= 1976 |pmid= 2009 |doi=  }}
*{{cite journal  |vauthors=Chern CJ, Beutler E |title=Biochemical and electrophoretic studies of erythrocyte pyridoxine kinase in white and black Americans |journal=Am. J. Hum. Genet. |volume=28 |issue= 1 |pages= 9–17 |year= 1976 |pmid= 2009 | pmc=1684914 }}
*{{cite journal  | author=Merrill AH, Henderson JM, Wang E, ''et al.'' |title=Metabolism of vitamin B-6 by human liver. |journal=J. Nutr. |volume=114 |issue= 9 |pages= 1664-74 |year= 1984 |pmid= 6088736 |doi=  }}
*{{cite journal  | author=Merrill AH |title=Metabolism of vitamin B-6 by human liver |journal=J. Nutr. |volume=114 |issue= 9 |pages= 1664–74 |year= 1984 |pmid= 6088736 |doi=  |name-list-format=vanc| author2=Henderson JM  | author3=Wang E | display-authors=3  | last4=McDonald  | first4=BW  | last5=Millikan  | first5=WJ  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Zhang Z, Smith E, Surowiec SM, ''et al.'' |title=Synthesis of N-(4'-pyridoxyl)sphingosine and its uptake and metabolism by isolated cells. |journal=Membrane biochemistry |volume=10 |issue= 1 |pages= 53-9 |year= 1993 |pmid= 8510562 |doi=  }}
*{{cite journal  | author=Zhang Z |title=Synthesis of N-(4'-pyridoxyl)sphingosine and its uptake and metabolism by isolated cells |journal=Membrane biochemistry |volume=10 |issue= 1 |pages= 53–9 |year= 1993 |pmid= 8510562 |doi=10.3109/09687689309150252 |name-list-format=vanc| author2=Smith E | author3=Surowiec SM  | display-authors=3  | last4=Merrill  | first4=Alfred H. | last5=McCormick  | first5=Donald B. }}
*{{cite journal  | author=Hanna MC, Turner AJ, Kirkness EF |title=Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor. |journal=J. Biol. Chem. |volume=272 |issue= 16 |pages= 10756-60 |year= 1997 |pmid= 9099727 |doi=  }}
*{{cite journal  |vauthors=Lainé-Cessac P, Cailleux A, Allain P |title=Mechanisms of the inhibition of human erythrocyte pyridoxal kinase by drugs |journal=Biochem. Pharmacol. |volume=54 |issue= 8 |pages= 863–70 |year= 1997 |pmid= 9354586 |doi=10.1016/S0006-2952(97)00252-9 }}
*{{cite journal | author=Lainé-Cessac P, Cailleux A, Allain P |title=Mechanisms of the inhibition of human erythrocyte pyridoxal kinase by drugs. |journal=Biochem. Pharmacol. |volume=54 |issue= 8 |pages= 863-70 |year= 1997 |pmid= 9354586 |doi=  }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Hattori M |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 |name-list-format=vanc| author2=Fujiyama A  | author3=Taylor TD  | display-authors=3  | last4=Taylor  | first4=T. D. | last5=Watanabe  | first5=H.  | last6=Yada  | first6=T.  | last7=Park  | first7=H.-S. | last8=Toyoda  | first8=A.  | last9=Ishii  | first9=K. }}
*{{cite journal  | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal  |vauthors=Lee HS, Moon BJ, Choi SY, Kwon OS |title=Human pyridoxal kinase: overexpression and properties of the recombinant enzyme |journal=Mol. Cells |volume=10 |issue= 4 |pages= 452–9 |year= 2001 |pmid= 10987144 |doi= }}
*{{cite journal | author=Lee HS, Moon BJ, Choi SY, Kwon OS |title=Human pyridoxal kinase: overexpression and properties of the recombinant enzyme. |journal=Mol. Cells |volume=10 |issue= 4 |pages= 452-9 |year= 2001 |pmid= 10987144 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner | first7=L | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Shin JH, Weitzdoerfer R, Fountoulakis M, Lubec G |title=Expression of cystathionine beta-synthase, pyridoxal kinase, and ES1 protein homolog (mitochondrial precursor) in fetal Down syndrome brain |journal=Neurochem. Int. |volume=45 |issue= 1 |pages= 73–9 |year= 2004 |pmid= 15082224 |doi= 10.1016/j.neuint.2003.12.004 }}
*{{cite journal  | author=Shin JH, Weitzdoerfer R, Fountoulakis M, Lubec G |title=Expression of cystathionine beta-synthase, pyridoxal kinase, and ES1 protein homolog (mitochondrial precursor) in fetal Down syndrome brain. |journal=Neurochem. Int. |volume=45 |issue= 1 |pages= 73-9 |year= 2004 |pmid= 15082224 |doi= 10.1016/j.neuint.2003.12.004 }}
*{{cite journal  | author=Fang X |title=Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis |journal=Asian J. Androl. |volume=6 |issue= 2 |pages= 83–91 |year= 2004 |pmid= 15154080 |doi= |name-list-format=vanc| author2=Zhou ZM  | author3=Lu L  | display-authors=3  | last4=Yin  | first4=LL  | last5=Li  | first5=JM  | last6=Zhen  | first6=Y  | last7=Wang  | first7=H  | last8=Sha  | first8=JH  }}
*{{cite journal  | author=Fang X, Zhou ZM, Lu L, ''et al.'' |title=Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis. |journal=Asian J. Androl. |volume=6 |issue= 2 |pages= 83-91 |year= 2004 |pmid= 15154080 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wang L |title=A two-dimensional electrophoresis reference map of human ovary |journal=J. Mol. Med. |volume=83 |issue= 10 |pages= 812–21 |year= 2006 |pmid= 16021519 |doi= 10.1007/s00109-005-0676-y  |name-list-format=vanc| author2=Zhu YF  | author3=Guo XJ  | display-authors=3  | last4=Huo  | first4=Ran  | last5=Ma  | first5=Xiang  | last6=Lin  | first6=Min  | last7=Zhou  | first7=Zuo-Min  | last8=Sha  | first8=Jia-Hao }}
*{{cite journal | author=Wang L, Zhu YF, Guo XJ, ''et al.'' |title=A two-dimensional electrophoresis reference map of human ovary. |journal=J. Mol. Med. |volume=83 |issue= 10 |pages= 812-21 |year= 2006 |pmid= 16021519 |doi= 10.1007/s00109-005-0676-y }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  |vauthors=Flanagan JM, Beutler E |title=The genetic basis of human erythrocyte pyridoxal kinase activity variation |journal=Haematologica |volume=91 |issue= 6 |pages= 801–4 |year= 2006 |pmid= 16704963 |doi=  }}
*{{cite journal  | author=Flanagan JM, Beutler E |title=The genetic basis of human erythrocyte pyridoxal kinase activity variation. |journal=Haematologica |volume=91 |issue= 6 |pages= 801-4 |year= 2006 |pmid= 16704963 |doi= }}
*{{cite journal  | author=Hu YH |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins |journal=BMC Genomics |volume=7|pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155  | pmc=1526728  |name-list-format=vanc| author2=Warnatz HJ  | author3=Vanhecke D  | display-authors=3  | last4=Wagner  | first4=Florian  | last5=Fiebitz  | first5=Andrea  | last6=Thamm  | first6=Sabine  | last7=Kahlem  | first7=Pascal  | last8=Lehrach  | first8=Hans  | last9=Yaspo  | first9=Marie-Laure }}
*{{cite journal  | author=Hu YH, Warnatz HJ, Vanhecke D, ''et al.'' |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. |journal=BMC Genomics |volume=7 |issue= |pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155 }}
*{{cite journal  | author=Musayev FN |title=Crystal Structure of human pyridoxal kinase: Structural basis of M+ and M2+ activation |journal=Protein Sci. |volume=16 |issue= 10 |pages= 2184–94 |year= 2007 |pmid= 17766369 |doi= 10.1110/ps.073022107 | pmc=2204131  |name-list-format=vanc| author2=di Salvo ML  | author3=Ko TP  | display-authors=3  | last4=Gandhi  | first4=Amit K.  | last5=Goswami  | first5=Ashwini  | last6=Schirch  | first6=Verne  | last7=Safo  | first7=Martin K. }}
*{{cite journal  | author=Musayev FN, di Salvo ML, Ko TP, ''et al.'' |title=Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation. |journal=Protein Sci. |volume=16 |issue= 10 |pages= 2184-94 |year= 2007 |pmid= 17766369 |doi= 10.1110/ps.073022107 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=8566}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{gene-21-stub}}
{{gene-21-stub}}
{{WikiDoc Sources}}

Revision as of 17:53, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pyridoxal kinase is an enzyme that in humans is encoded by the PDXK gene.[1][2]

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[2]

References

  1. ↑ Hanna MC, Turner AJ, Kirkness EF (May 1997). "Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor". J Biol Chem. 272 (16): 10756–60. doi:10.1074/jbc.272.16.10756. PMID 9099727.
  2. ↑ 2.0 2.1 "Entrez Gene: PDXK pyridoxal (pyridoxine, vitamin B6) kinase".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=PDXK&oldid=1419842"