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{{ | '''Poly [ADP-ribose] polymerase 4''' is an [[enzyme]] that in humans is encoded by the ''PARP4'' [[gene]].<ref name="pmid10644454">{{cite journal |vauthors=Still IH, Vince P, Cowell JK | title = Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein | journal = Genomics | volume = 62 | issue = 3 | pages = 533–6 |date=Mar 2000 | pmid = 10644454 | pmc = | doi = 10.1006/geno.1999.6024 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PARP4 poly (ADP-ribose) polymerase family, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=143| accessdate = }}</ref> | ||
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| summary_text = This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.<ref name="entrez" | | summary_text = This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.<ref name="entrez"/> | ||
}} | }} | ||
==Interactions== | |||
PARP4 has been shown to [[Protein-protein interaction|interact]] with [[Major vault protein]].<ref name=pmid11855821>{{cite journal |last=van Zon |first=Arend |authorlink= |author2=Mossink Marieke H |author3=Schoester Martijn |author4=Scheffer George L |author5=Scheper Rik J |author6=Sonneveld Pieter |author7=Wiemer Erik A C |date=Mar 2002 |title=Structural domains of vault proteins: a role for the coiled coil domain in vault assembly |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue=3 |pages=535–41 |publisher= |location = United States| issn = 0006-291X| pmid = 11855821 |doi = 10.1006/bbrc.2002.6472 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10477748>{{cite journal |doi=10.1083/jcb.146.5.917 |last=Kickhoefer |first=V A |authorlink= |author2=Siva A C |author3=Kedersha N L |author4=Inman E M |author5=Ruland C |author6=Streuli M |author7=Rome L H |date=Sep 1999 |title=The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase |journal=J. Cell Biol. |volume=146 |issue=5 |pages=917–28 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 10477748 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2169495 }}</ref> | |||
==References== | ==References== | ||
<references/> | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
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| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Jean L, Risler JL, Nagase T, etal |title=The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? |journal=FEBS Lett. |volume=446 |issue= 1 |pages= 6–8 |year= 1999 |pmid= 10100603 |doi=10.1016/S0014-5793(99)00173-8 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Soldani C, Scovassi AI |title=Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. |journal=Apoptosis |volume=7 |issue= 4 |pages= 321–8 |year= 2003 |pmid= 12101391 |doi=10.1023/A:1016119328968 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Bouchard VJ, Rouleau M, Poirier GG |title=PARP-1, a determinant of cell survival in response to DNA damage. |journal=Exp. Hematol. |volume=31 |issue= 6 |pages= 446–54 |year= 2003 |pmid= 12829019 |doi=10.1016/S0301-472X(03)00083-3 }} | ||
*{{cite journal | *{{cite journal |vauthors=Soares MB, Bonaldo MF, Jelene P, etal |title=Construction and characterization of a normalized cDNA library. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 20 |pages= 9228–32 |year= 1994 |pmid= 7937745 |doi=10.1073/pnas.91.20.9228 | pmc=44785 }} | ||
*{{cite journal | *{{cite journal |vauthors=Nagase T, Seki N, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=3 |issue= 1 |pages= 17–24 |year= 1996 |pmid= 8724849 |doi=10.1093/dnares/3.1.17 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kickhoefer VA, Siva AC, Kedersha NL, etal |title=The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 917–28 |year= 1999 |pmid= 10477748 |doi=10.1083/jcb.146.5.917 | pmc=2169495 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kickhoefer VA, Stephen AG, Harrington L, etal |title=Vaults and telomerase share a common subunit, TEP1. |journal=J. Biol. Chem. |volume=274 |issue= 46 |pages= 32712–7 |year= 2000 |pmid= 10551828 |doi=10.1074/jbc.274.46.32712 }} | ||
*{{cite journal |vauthors=Siva AC, Raval-Fernandes S, Stephen AG, etal |title=Up-regulation of vaults may be necessary but not sufficient for multidrug resistance. |journal=Int. J. Cancer |volume=92 |issue= 2 |pages= 195–202 |year= 2001 |pmid= 11291045 |doi=10.1002/1097-0215(200102)9999:9999<::AID-IJC1168>3.0.CO;2-7 }} | |||
*{{cite journal | *{{cite journal |vauthors=van Zon A, Mossink MH, Schoester M, etal |title=Multiple human vault RNAs. Expression and association with the vault complex. |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 37715–21 |year= 2001 |pmid= 11479319 |doi= 10.1074/jbc.M106055200 }} | ||
*{{cite journal | *{{cite journal |vauthors=van Zon A, Mossink MH, Schoester M, etal |title=Structural domains of vault proteins: a role for the coiled coil domain in vault assembly. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 3 |pages= 535–41 |year= 2002 |pmid= 11855821 |doi= 10.1006/bbrc.2002.6472 }} | ||
*{{cite journal | *{{cite journal |vauthors=Mazzon E, Dugo L, Li JH, etal |title=GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat. |journal=Biochem. Pharmacol. |volume=64 |issue= 2 |pages= 327–37 |year= 2002 |pmid= 12123754 |doi=10.1016/S0006-2952(02)01075-4 }} | ||
*{{cite journal | *{{cite journal |vauthors=Liu TJ, Lin SY, Chau YP |title=Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. |journal=Toxicol. Appl. Pharmacol. |volume=182 |issue= 2 |pages= 116–25 |year= 2002 |pmid= 12140175 |doi=10.1006/taap.2002.9438 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Nie Z, Phenix BN, Lum JJ, etal |title=HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation. |journal=Cell Death Differ. |volume=9 |issue= 11 |pages= 1172–84 |year= 2003 |pmid= 12404116 |doi= 10.1038/sj.cdd.4401094 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 }} | ||
*{{cite journal | *{{cite journal |vauthors=Liu Y, Snow BE, Kickhoefer VA, etal |title=Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 12 |pages= 5314–23 |year= 2004 |pmid= 15169895 |doi= 10.1128/MCB.24.12.5314-5323.2004 | pmc=419898 }} | ||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Revision as of 17:34, 7 September 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
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Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.[1][2]
This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.[2]
Interactions
PARP4 has been shown to interact with Major vault protein.[3][4]
References
- ↑ Still IH, Vince P, Cowell JK (Mar 2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein". Genomics. 62 (3): 533–6. doi:10.1006/geno.1999.6024. PMID 10644454.
- ↑ 2.0 2.1 "Entrez Gene: PARP4 poly (ADP-ribose) polymerase family, member 4".
- ↑ van Zon, Arend; Mossink Marieke H; Schoester Martijn; Scheffer George L; Scheper Rik J; Sonneveld Pieter; Wiemer Erik A C (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. United States. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. ISSN 0006-291X. PMID 11855821.
- ↑ Kickhoefer, V A; Siva A C; Kedersha N L; Inman E M; Ruland C; Streuli M; Rome L H (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". J. Cell Biol. UNITED STATES. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. ISSN 0021-9525. PMC 2169495. PMID 10477748.
Further reading
- Jean L, Risler JL, Nagase T, et al. (1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603.
- Soldani C, Scovassi AI (2003). "Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update". Apoptosis. 7 (4): 321–8. doi:10.1023/A:1016119328968. PMID 12101391.
- Bouchard VJ, Rouleau M, Poirier GG (2003). "PARP-1, a determinant of cell survival in response to DNA damage". Exp. Hematol. 31 (6): 446–54. doi:10.1016/S0301-472X(03)00083-3. PMID 12829019.
- Soares MB, Bonaldo MF, Jelene P, et al. (1994). "Construction and characterization of a normalized cDNA library". Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9228–32. doi:10.1073/pnas.91.20.9228. PMC 44785. PMID 7937745.
- Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
- Kickhoefer VA, Siva AC, Kedersha NL, et al. (1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". J. Cell Biol. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. PMC 2169495. PMID 10477748.
- Kickhoefer VA, Stephen AG, Harrington L, et al. (2000). "Vaults and telomerase share a common subunit, TEP1". J. Biol. Chem. 274 (46): 32712–7. doi:10.1074/jbc.274.46.32712. PMID 10551828.
- Siva AC, Raval-Fernandes S, Stephen AG, et al. (2001). "Up-regulation of vaults may be necessary but not sufficient for multidrug resistance". Int. J. Cancer. 92 (2): 195–202. doi:10.1002/1097-0215(200102)9999:9999<::AID-IJC1168>3.0.CO;2-7. PMID 11291045.
- van Zon A, Mossink MH, Schoester M, et al. (2001). "Multiple human vault RNAs. Expression and association with the vault complex". J. Biol. Chem. 276 (40): 37715–21. doi:10.1074/jbc.M106055200. PMID 11479319.
- van Zon A, Mossink MH, Schoester M, et al. (2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID 11855821.
- Mazzon E, Dugo L, Li JH, et al. (2002). "GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat". Biochem. Pharmacol. 64 (2): 327–37. doi:10.1016/S0006-2952(02)01075-4. PMID 12123754.
- Liu TJ, Lin SY, Chau YP (2002). "Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells". Toxicol. Appl. Pharmacol. 182 (2): 116–25. doi:10.1006/taap.2002.9438. PMID 12140175.
- Nie Z, Phenix BN, Lum JJ, et al. (2003). "HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation". Cell Death Differ. 9 (11): 1172–84. doi:10.1038/sj.cdd.4401094. PMID 12404116.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Liu Y, Snow BE, Kickhoefer VA, et al. (2004). "Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo". Mol. Cell. Biol. 24 (12): 5314–23. doi:10.1128/MCB.24.12.5314-5323.2004. PMC 419898. PMID 15169895.
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