MPP1: Difference between revisions

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Latest revision as of 06:47, 4 September 2017

55 kDa erythrocyte membrane protein is a protein that in humans is encoded by the MPP1 gene.^[1]^[2]

Palmitoylated membrane protein 1 is the prototype of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 1 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.^[2]

References

↑ Ruff P, Speicher DW, Husain-Chishti A (Sep 1991). "Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif". Proc Natl Acad Sci U S A. 88 (15): 6595–9. doi:10.1073/pnas.88.15.6595. PMC 52133. PMID 1713685.
↑ ^2.0 ^2.1 "Entrez Gene: MPP1 membrane protein, palmitoylated 1, 55kDa".

Metzenberg AB, Gitschier J (1993). "The gene encoding the palmitoylated erythrocyte membrane protein, p55, originates at the CpG island 3' to the factor VIII gene". Hum. Mol. Genet. 1 (2): 97–101. doi:10.1093/hmg/1.2.97. PMID 1301163.
Bryant PJ, Woods DF (1992). "A major palmitoylated membrane protein of human erythrocytes shows homology to yeast guanylate kinase and to the product of a Drosophila tumor suppressor gene". Cell. 68 (4): 621–2. doi:10.1016/0092-8674(92)90136-Z. PMID 1310897.
Marfatia SM, Leu RA, Branton D, Chishti AH (1995). "Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein". J. Biol. Chem. 270 (2): 715–9. doi:10.1074/jbc.270.2.715. PMID 7822301.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kim AC, Metzenberg AB, Sahr KE, et al. (1997). "Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue". Genomics. 31 (2): 223–9. doi:10.1006/geno.1996.0035. PMID 8824805.
Marfatia SM, Morais-Cabral JH, Kim AC, et al. (1997). "The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis". J. Biol. Chem. 272 (39): 24191–7. doi:10.1074/jbc.272.39.24191. PMID 9305870.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kusunoki H, Kohno T (2006). "Solution structure of human erythroid p55 PDZ domain". Proteins. 64 (3): 804–7. doi:10.1002/prot.21028. PMID 16741958.
Gosens I, van Wijk E, Kersten FF, et al. (2007). "MPP1 links the Usher protein network and the Crumbs protein complex in the retina". Hum. Mol. Genet. 16 (16): 1993–2003. doi:10.1093/hmg/ddm147. PMID 17584769.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[pmid1713685-1] Ruff P, Speicher DW, Husain-Chishti A (Sep 1991). "Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif". Proc Natl Acad Sci U S A. 88 (15): 6595–9. doi:10.1073/pnas.88.15.6595. PMC 52133. PMID 1713685.

[entrez-2] 2.0 ^2.1 "Entrez Gene: MPP1 membrane protein, palmitoylated 1, 55kDa".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=October 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''55 kDa erythrocyte membrane protein''' is a [[protein]] that in humans is encoded by the ''MPP1'' [[gene]].<ref name="pmid1713685">{{cite journal |vauthors=Ruff P, Speicher DW, Husain-Chishti A | title = Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 15 | pages = 6595–9 |date=Sep 1991 | pmid = 1713685 | pmc = 52133 | doi =10.1073/pnas.88.15.6595  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MPP1 membrane protein, palmitoylated 1, 55kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4354| accessdate = }}</ref>
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- | image = PBB_Protein_MPP1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ev8.
- | PDB = {{PDB2|2ev8}}
- | Name = Membrane protein, palmitoylated 1, 55kDa
- | HGNCid = 7219
- | Symbol = MPP1
- | AltSymbols =; MRG1; AAG12; DXS552; DXS552E; EMP55; PEMP
- | OMIM = 305360
- | ECnumber =
- | Homologene = 1826
- | MGIid = 105941
- | GeneAtlas_image1 = PBB_GE_MPP1_202974_at_tn.png
- | Function = {{GNF_GO|id=GO:0004385 |text = guanylate kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
-  | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 4354
-    | Hs_Ensembl = ENSG00000130830
-    | Hs_RefseqProtein = NP_002427
-    | Hs_RefseqmRNA = NM_002436
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = X
-    | Hs_GenLoc_start = 153660153
-    | Hs_GenLoc_end = 153686977
-    | Hs_Uniprot = Q00013
-    | Mm_EntrezGene = 17524
-    | Mm_Ensembl = ENSMUSG00000031402
-    | Mm_RefseqmRNA = NM_008621
-    | Mm_RefseqProtein = NP_032647
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = X
-    | Mm_GenLoc_start = 71362453
-    | Mm_GenLoc_end = 71383669
-    | Mm_Uniprot = Q542P4
-  }}
-}}
-'''Membrane protein, palmitoylated 1, 55kDa''', also known as '''MPP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MPP1 membrane protein, palmitoylated 1, 55kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4354| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Palmitoylated membrane protein 1 is the prototype of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs).  MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions.  Palmitoylated membrane protein 1 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.<ref name="entrez">{{cite web | title = Entrez Gene: MPP1 membrane protein, palmitoylated 1, 55kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4354| accessdate = }}</ref>
+| summary_text = Palmitoylated membrane protein 1 is the prototype of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs).  MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions.  Palmitoylated membrane protein 1 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Metzenberg AB, Gitschier J |title=The gene encoding the palmitoylated erythrocyte membrane protein, p55, originates at the CpG island 3' to the factor VIII gene. |journal=Hum. Mol. Genet. |volume=1 |issue= 2 |pages= 97-101 |year= 1993 |pmid= 1301163 |doi=  }}
+*{{cite journal  |vauthors=Metzenberg AB, Gitschier J |title=The gene encoding the palmitoylated erythrocyte membrane protein, p55, originates at the CpG island 3' to the factor VIII gene |journal=Hum. Mol. Genet. |volume=1 |issue= 2 |pages= 97–101 |year= 1993 |pmid= 1301163 |doi=10.1093/hmg/1.2.97  }}
-*{{cite journal  | author=Bryant PJ, Woods DF |title=A major palmitoylated membrane protein of human erythrocytes shows homology to yeast guanylate kinase and to the product of a Drosophila tumor suppressor gene. |journal=Cell |volume=68 |issue= 4 |pages= 621-2 |year= 1992 |pmid= 1310897 |doi=  }}
+*{{cite journal  |vauthors=Bryant PJ, Woods DF |title=A major palmitoylated membrane protein of human erythrocytes shows homology to yeast guanylate kinase and to the product of a Drosophila tumor suppressor gene |journal=Cell |volume=68 |issue= 4 |pages= 621–2 |year= 1992 |pmid= 1310897 |doi=10.1016/0092-8674(92)90136-Z  }}
-*{{cite journal  | author=Ruff P, Speicher DW, Husain-Chishti A |title=Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 15 |pages= 6595-9 |year= 1991 |pmid= 1713685 |doi=  }}
+*{{cite journal  |vauthors=Marfatia SM, Leu RA, Branton D, Chishti AH |title=Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 715–9 |year= 1995 |pmid= 7822301 |doi=10.1074/jbc.270.2.715  }}
-*{{cite journal  | author=Marfatia SM, Leu RA, Branton D, Chishti AH |title=Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 715-9 |year= 1995 |pmid= 7822301 |doi=  }}
+*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal   |vauthors=Kim AC, Metzenberg AB, Sahr KE, etal |title=Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue |journal=Genomics |volume=31 |issue= 2 |pages= 223–9 |year= 1997 |pmid= 8824805 |doi= 10.1006/geno.1996.0035 }}
-*{{cite journal  | author=Kim AC, Metzenberg AB, Sahr KE, ''et al.'' |title=Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue. |journal=Genomics |volume=31 |issue= 2 |pages= 223-9 |year= 1997 |pmid= 8824805 |doi= 10.1006/geno.1996.0035 }}
+*{{cite journal   |vauthors=Marfatia SM, Morais-Cabral JH, Kim AC, etal |title=The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24191–7 |year= 1997 |pmid= 9305870 |doi=10.1074/jbc.272.39.24191  }}
-*{{cite journal  | author=Marfatia SM, Morais-Cabral JH, Kim AC, ''et al.'' |title=The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24191-7 |year= 1997 |pmid= 9305870 |doi=  }}
+*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 }}
-*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
-*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal  |vauthors=Kusunoki H, Kohno T |title=Solution structure of human erythroid p55 PDZ domain |journal=Proteins |volume=64 |issue= 3 |pages= 804–7 |year= 2006 |pmid= 16741958 |doi= 10.1002/prot.21028 }}
-*{{cite journal  | author=Kusunoki H, Kohno T |title=Solution structure of human erythroid p55 PDZ domain. |journal=Proteins |volume=64 |issue= 3 |pages= 804-7 |year= 2006 |pmid= 16741958 |doi= 10.1002/prot.21028 }}
+*{{cite journal   |vauthors=Gosens I, van Wijk E, Kersten FF, etal |title=MPP1 links the Usher protein network and the Crumbs protein complex in the retina |journal=Hum. Mol. Genet. |volume=16 |issue= 16 |pages= 1993–2003 |year= 2007 |pmid= 17584769 |doi= 10.1093/hmg/ddm147 }}
-*{{cite journal  | author=Gosens I, van Wijk E, Kersten FF, ''et al.'' |title=MPP1 links the Usher protein network and the Crumbs protein complex in the retina. |journal=Hum. Mol. Genet. |volume=16 |issue= 16 |pages= 1993-2003 |year= 2007 |pmid= 17584769 |doi= 10.1093/hmg/ddm147 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=4354}}
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+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
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MPP1: Difference between revisions

Latest revision as of 06:47, 4 September 2017

References

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