CYFIP1: Difference between revisions

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{{Infobox_gene}}
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'''Cytoplasmic FMR1-interacting protein 1''' is a [[protein]] that in humans is encoded by the ''CYFIP1'' [[gene]].<ref name="pmid11438699">{{cite journal | vauthors = Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL | title = A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 15 | pages = 8844–9 |date=Jul 2001 | pmid = 11438699 | pmc = 37523 | doi = 10.1073/pnas.151231598 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CYFIP1 cytoplasmic FMR1 interacting protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23191| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytoplasmic FMR1 interacting protein 1
| HGNCid = 13759
| Symbol = CYFIP1
| AltSymbols =; FLJ45151; P140SRA-1; SHYC
| OMIM = 606322
| ECnumber =
| Homologene = 22628
| MGIid = 1338801
| GeneAtlas_image1 = PBB_GE_CYFIP1_208923_at_tn.png
| Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23191
    | Hs_Ensembl = ENSG00000068793
    | Hs_RefseqProtein = NP_001028200
    | Hs_RefseqmRNA = NM_001033028
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 20444104
    | Hs_GenLoc_end = 20555043
    | Hs_Uniprot =
    | Mm_EntrezGene = 20430
    | Mm_Ensembl = ENSMUSG00000030447
    | Mm_RefseqmRNA = NM_011370
    | Mm_RefseqProtein = NP_035500
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 55710046
    | Mm_GenLoc_end = 55798717
    | Mm_Uniprot = 
  }}
}}
'''Cytoplasmic FMR1 interacting protein 1''', also known as '''CYFIP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CYFIP1 cytoplasmic FMR1 interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23191| accessdate = }}</ref>


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}}
==Interactions==
CYFIP1 has been shown to [[Protein-protein interaction|interact]] with [[FMR1]],<ref name=pmid11438699/> to the exclusion of [[FXR1]] and [[FXR2]].<ref name=pmid11438699 /> It also forms part of the [[WAVE regulatory complex]] (WRC),<ref name="pmid21107423">{{cite journal | vauthors = Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK | title = Structure and control of the actin regulatory WAVE complex| journal = Nature | volume = 468| issue = 7323 | pages = 533–8 |date=25 Nov 2010 | pmid =  21107423| pmc = 3085272 | doi = 10.1038/nature09623 }}</ref> and based on the crystal structure of the WRC it is believed CYFIP1 provides the binding site for the complex to [[Rac1]].<ref name="pmid21844371">{{cite journal | vauthors = Koronakis V, Hume PJ, Humphreys D, Liu T, Hørning O, Jensen ON, McGhie EJ | title = WAVE regulatory complex activation by cooperating GTPases Arf and Rac1| journal = Proc Natl Acad Sci U S A | volume = 108| issue = 35 | pages = 14449–54 |date=30 Aug 2011 | pmid =  21844371 | pmc = 3167530 | doi = 10.1073/pnas.1107666108 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223-9 |year= 1995 |pmid= 7584044 |doi=  }}
*{{cite journal  | vauthors=Nomura N, Nagase T, Miyajima N |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=10.1093/dnares/1.5.223 |display-authors=etal}}
*{{cite journal  | author=Kobayashi K, Kuroda S, Fukata M, ''et al.'' |title=p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. |journal=J. Biol. Chem. |volume=273 |issue= 1 |pages= 291-5 |year= 1998 |pmid= 9417078 |doi=  }}
*{{cite journal  | vauthors=Kobayashi K, Kuroda S, Fukata M |title=p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. |journal=J. Biol. Chem. |volume=273 |issue= 1 |pages= 291–5 |year= 1998 |pmid= 9417078 |doi=10.1074/jbc.273.1.291 |display-authors=etal}}
*{{cite journal  | author=Witke W, Podtelejnikov AV, Di Nardo A, ''et al.'' |title=In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. |journal=EMBO J. |volume=17 |issue= 4 |pages= 967-76 |year= 1998 |pmid= 9463375 |doi= 10.1093/emboj/17.4.967 }}
*{{cite journal  | vauthors=Witke W, Podtelejnikov AV, Di Nardo A |title=In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. |journal=EMBO J. |volume=17 |issue= 4 |pages= 967–76 |year= 1998 |pmid= 9463375 |doi= 10.1093/emboj/17.4.967  | pmc=1170446 |display-authors=etal}}
*{{cite journal | author=Schenck A, Bardoni B, Moro A, ''et al.'' |title=A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 15 |pages= 8844-9 |year= 2001 |pmid= 11438699 |doi= 10.1073/pnas.151231598 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Chai JH, Locke DP, Greally JM |title=Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. |journal=Am. J. Hum. Genet. |volume=73 |issue= 4 |pages= 898–925 |year= 2003 |pmid= 14508708 |doi=10.1086/378816 | pmc=1180611  |display-authors=etal}}
*{{cite journal  | author=Chai JH, Locke DP, Greally JM, ''et al.'' |title=Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. |journal=Am. J. Hum. Genet. |volume=73 |issue= 4 |pages= 898-925 |year= 2003 |pmid= 14508708 |doi=  }}
*{{cite journal  | vauthors=Brajenovic M, Joberty G, Küster B |title=Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12804–11 |year= 2004 |pmid= 14676191 |doi= 10.1074/jbc.M312171200 |display-authors=etal}}
*{{cite journal  | author=Brajenovic M, Joberty G, Küster B, ''et al.'' |title=Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12804-11 |year= 2004 |pmid= 14676191 |doi= 10.1074/jbc.M312171200 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Innocenti M, Zucconi A, Disanza A |title=Abi1 is essential for the formation and activation of a WAVE2 signalling complex. |journal=Nat. Cell Biol. |volume=6 |issue= 4 |pages= 319–27 |year= 2004 |pmid= 15048123 |doi= 10.1038/ncb1105 |display-authors=etal}}
*{{cite journal  | author=Innocenti M, Zucconi A, Disanza A, ''et al.'' |title=Abi1 is essential for the formation and activation of a WAVE2 signalling complex. |journal=Nat. Cell Biol. |volume=6 |issue= 4 |pages= 319-27 |year= 2004 |pmid= 15048123 |doi= 10.1038/ncb1105 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Kawano Y, Yoshimura T, Tsuboi D |title=CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. |journal=Mol. Cell. Biol. |volume=25 |issue= 22 |pages= 9920–35 |year= 2005 |pmid= 16260607 |doi= 10.1128/MCB.25.22.9920-9935.2005 | pmc=1280248 |display-authors=etal}}
*{{cite journal  | author=Kawano Y, Yoshimura T, Tsuboi D, ''et al.'' |title=CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. |journal=Mol. Cell. Biol. |volume=25 |issue= 22 |pages= 9920-35 |year= 2005 |pmid= 16260607 |doi= 10.1128/MCB.25.22.9920-9935.2005 }}
*{{cite journal  | vauthors=Bittel DC, Kibiryeva N, Butler MG |title=Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome. |journal=Pediatrics |volume=118 |issue= 4 |pages= e1276–83 |year= 2006 |pmid= 16982806 |doi= 10.1542/peds.2006-0424 }}
*{{cite journal  | author=Bittel DC, Kibiryeva N, Butler MG |title=Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome. |journal=Pediatrics |volume=118 |issue= 4 |pages= e1276-83 |year= 2006 |pmid= 16982806 |doi= 10.1542/peds.2006-0424 }}
*{{cite journal | vauthors = Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK | title = Structure and control of the actin regulatory WAVE complex| journal = Nature | volume = 468| issue = 7323 | pages = 533–8 |date=25 Nov 2010 | pmid =  21107423| pmc = 3085272 | doi = 10.1038/nature09623 }}
*{{cite journal | vauthors = Koronakis V, Hume PJ, Humphreys D, Liu T, Hørning O, Jensen ON, McGhie EJ | title = WAVE regulatory complex activation by cooperating GTPases Arf and Rac1| journal = Proc Natl Acad Sci U S A | volume = 108| issue = 35 | pages = 14449–54 |date=30 Aug 2011 | pmid =  21844371 | pmc = 3167530 | doi = 10.1073/pnas.1107666108 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC gene info|CYFIP1}}
* {{UCSC gene info|SRA1}}
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Latest revision as of 10:14, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cytoplasmic FMR1-interacting protein 1 is a protein that in humans is encoded by the CYFIP1 gene.[1][2]


Interactions

CYFIP1 has been shown to interact with FMR1,[1] to the exclusion of FXR1 and FXR2.[1] It also forms part of the WAVE regulatory complex (WRC),[3] and based on the crystal structure of the WRC it is believed CYFIP1 provides the binding site for the complex to Rac1.[4]

References

  1. ↑ 1.0 1.1 1.2 Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL (Jul 2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proc Natl Acad Sci U S A. 98 (15): 8844–9. doi:10.1073/pnas.151231598. PMC 37523. PMID 11438699.
  2. ↑ "Entrez Gene: CYFIP1 cytoplasmic FMR1 interacting protein 1".
  3. ↑ Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK (25 Nov 2010). "Structure and control of the actin regulatory WAVE complex". Nature. 468 (7323): 533–8. doi:10.1038/nature09623. PMC 3085272. PMID 21107423.
  4. ↑ Koronakis V, Hume PJ, Humphreys D, Liu T, Hørning O, Jensen ON, McGhie EJ (30 Aug 2011). "WAVE regulatory complex activation by cooperating GTPases Arf and Rac1". Proc Natl Acad Sci U S A. 108 (35): 14449–54. doi:10.1073/pnas.1107666108. PMC 3167530. PMID 21844371.

Further reading

External links


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