CTNNAL1: Difference between revisions

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{{Infobox_gene}}
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'''Alpha-catulin''' is a [[protein]] that in humans is encoded by the ''CTNNAL1'' [[gene]].<ref name="pmid9806841">{{cite journal | vauthors = Zhang JS, Nelson M, Wang L, Liu W, Qian CP, Shridhar V, Urrutia R, Smith DI | title = Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin | journal = Genomics | volume = 54 | issue = 1 | pages = 149–54 | date = Jan 1999 | pmid = 9806841 | pmc = | doi = 10.1006/geno.1998.5458 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CTNNAL1 catenin (cadherin-associated protein), alpha-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8727| accessdate = }}</ref>
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== Interactions ==
{{GNF_Protein_box
CTNNAL1 has been shown to [[Protein-protein interaction|interact]] with [[AKAP13]].<ref name=pmid12270917>{{cite journal | vauthors = Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D | title = Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation | language = | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45361–70 | date = Nov 2002 | pmid = 12270917 | doi = 10.1074/jbc.M202447200 }}</ref>
| image = 
| image_source =
| PDB =  
| Name = Catenin (cadherin-associated protein), alpha-like 1
| HGNCid = 2512
| Symbol = CTNNAL1
| AltSymbols =; CLLP; alpha-CATU
| OMIM = 604785
| ECnumber = 
| Homologene = 2815
| MGIid = 1859649
| GeneAtlas_image1 = PBB_GE_CTNNAL1_202468_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0045296 |text = cadherin binding}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8727
    | Hs_Ensembl = ENSG00000119326
    | Hs_RefseqProtein = NP_003789
    | Hs_RefseqmRNA = NM_003798
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 110744672
    | Hs_GenLoc_end = 110815630
    | Hs_Uniprot = Q9UBT7
    | Mm_EntrezGene = 54366
    | Mm_Ensembl = ENSMUSG00000038816
    | Mm_RefseqmRNA = XM_980596
    | Mm_RefseqProtein = XP_985690
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 56904989
    | Mm_GenLoc_end = 56959242
    | Mm_Uniprot = O88327
  }}
}}
'''Catenin (cadherin-associated protein), alpha-like 1''', also known as '''CTNNAL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CTNNAL1 catenin (cadherin-associated protein), alpha-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8727| accessdate = }}</ref>


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== References==
{{PBB_Summary
{{reflist}}
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| summary_text =
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==References==
==External links==
{{reflist|2}}
* {{UCSC gene info|CTNNAL1}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Janssens B, Staes K, van Roy F | title = Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing | journal = Biochim. Biophys. Acta | volume = 1447 | issue = 2–3 | pages = 341–7 | year = 1999 | pmid = 10542337 | doi = 10.1016/s0167-4781(99)00170-0 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Demacio PC, Ray PN | title = Alpha-catulin maps to the familial dysautonomia region on 9q31 | journal = Genome | volume = 44 | issue = 6 | pages = 990–4 | year = 2002 | pmid = 11768226 | doi = 10.1139/gen-44-6-990 }}
*{{cite journal  | author=Zhang JS, Nelson M, Wang L, ''et al.'' |title=Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. |journal=Genomics |volume=54 |issue= 1 |pages= 149-54 |year= 1999 |pmid= 9806841 |doi= 10.1006/geno.1998.5458 }}
* {{cite journal | vauthors = Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D | title = Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45361–70 | year = 2003 | pmid = 12270917 | doi = 10.1074/jbc.M202447200 }}
*{{cite journal | author=Janssens B, Staes K, van Roy F |title=Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing. |journal=Biochim. Biophys. Acta |volume=1447 |issue= 2-3 |pages= 341-7 |year= 1999 |pmid= 10542337 |doi= }}
* {{cite journal | vauthors = Shieh YS, Chang LC, Chiu KC, Wu CW, Lee HS | title = Cadherin and catenin expression in mucoepidermoid carcinoma: correlation with histopathologic grade, clinical stage, and patient outcome | journal = J. Oral Pathol. Med. | volume = 32 | issue = 5 | pages = 297–304 | year = 2003 | pmid = 12694354 | doi = 10.1034/j.1600-0714.2003.00144.x }}
*{{cite journal | author=Demacio PC, Ray PN |title=Alpha-catulin maps to the familial dysautonomia region on 9q31. |journal=Genome |volume=44 |issue= 6 |pages= 990-4 |year= 2002 |pmid= 11768226 |doi= }}
* {{cite journal | vauthors = Surpili MJ, Delben TM, Kobarg J | title = Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1 | journal = Biochemistry | volume = 42 | issue = 51 | pages = 15369–76 | year = 2004 | pmid = 14690447 | doi = 10.1021/bi034575v }}
*{{cite journal | author=Park B, Nguyen NT, Dutt P, ''et al.'' |title=Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45361-70 |year= 2003 |pmid= 12270917 |doi= 10.1074/jbc.M202447200 }}
* {{cite journal | vauthors = Merdek KD, Nguyen NT, Toksoz D | title = Distinct Activities of the α-Catenin Family, α-Catulin and α-Catenin, on β-Catenin-Mediated Signaling | journal = Mol. Cell. Biol. | volume = 24 | issue = 6 | pages = 2410–22 | year = 2004 | pmid = 14993280 | pmc = 355851 | doi = 10.1128/mcb.24.6.2410-2422.2004 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Shieh YS, Chang LC, Chiu KC, ''et al.'' |title=Cadherin and catenin expression in mucoepidermoid carcinoma: correlation with histopathologic grade, clinical stage, and patient outcome. |journal=J. Oral Pathol. Med. |volume=32 |issue= 5 |pages= 297-304 |year= 2003 |pmid= 12694354 |doi= }}
*{{cite journal | author=Surpili MJ, Delben TM, Kobarg J |title=Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. |journal=Biochemistry |volume=42 |issue= 51 |pages= 15369-76 |year= 2004 |pmid= 14690447 |doi= 10.1021/bi034575v }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Merdek KD, Nguyen NT, Toksoz D |title=Distinct activities of the alpha-catenin family, alpha-catulin and alpha-catenin, on beta-catenin-mediated signaling. |journal=Mol. Cell. Biol. |volume=24 |issue= 6 |pages= 2410-22 |year= 2004 |pmid= 14993280 |doi= }}
*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:45, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Alpha-catulin is a protein that in humans is encoded by the CTNNAL1 gene.[1][2]

Interactions

CTNNAL1 has been shown to interact with AKAP13.[3]

References

  1. ↑ Zhang JS, Nelson M, Wang L, Liu W, Qian CP, Shridhar V, Urrutia R, Smith DI (Jan 1999). "Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin". Genomics. 54 (1): 149–54. doi:10.1006/geno.1998.5458. PMID 9806841.
  2. ↑ "Entrez Gene: CTNNAL1 catenin (cadherin-associated protein), alpha-like 1".
  3. ↑ Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D (Nov 2002). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi:10.1074/jbc.M202447200. PMID 12270917.

External links

Further reading


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