CHKB (gene): Difference between revisions

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{{Infobox_gene}}
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'''Choline kinase beta''' is a [[protein]] encoded by the '''CHKB''' [[gene]].<ref name="pmid9224698">{{cite journal | vauthors = Yamazaki N, Yamanaka Y, Hashimoto Y, Shinohara Y, Shima A, Terada H | title = Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I | journal = FEBS Lett. | volume = 409 | issue = 3 | pages = 401–6 |date=June 1997 | pmid = 9224698 | doi = 10.1016/S0014-5793(97)00561-9 | url =  }}</ref><ref name="pmid15003397">{{cite journal | vauthors = Aoyama C, Liao H, Ishidate K | title = Structure and function of choline kinase isoforms in mammalian cells | journal = Prog. Lipid Res. | volume = 43 | issue = 3 | pages = 266–81 |date=May 2004 | pmid = 15003397 | doi = 10.1016/j.plipres.2003.12.001 | url =  }}</ref>  This gene is found on chromosome 22 in humans.<ref name="entrez">{{cite web | title = Entrez Gene: CHKB choline kinase beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1120| accessdate = }}</ref>
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[[Choline kinase]] (CK) and [[ethanolamine kinase]] (EK) catalyze the phosphorylation of [[choline]]/[[ethanolamine]] to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the [[choline/ethanolamine kinase family]]; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.<ref name="entrez" />
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==References==
{{GNF_Protein_box
{{reflist}}
| image = PBB_Protein_CHKB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ig7.
| PDB = {{PDB2|2ig7}}
| Name = Choline kinase beta
| HGNCid = 1938
| Symbol = CHKB
| AltSymbols =; CHETK; CHKL
| OMIM = 
| ECnumber = 
| Homologene = 88718
| MGIid = 1328313
| GeneAtlas_image1 = PBB_GE_CHKB_204193_at_tn.png
| Function = {{GNF_GO|id=GO:0004103 |text = choline kinase activity}} {{GNF_GO|id=GO:0004305 |text = ethanolamine kinase activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006656 |text = phosphatidylcholine biosynthetic process}} {{GNF_GO|id=GO:0007517 |text = muscle development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1120
    | Hs_Ensembl = ENSG00000205560
    | Hs_RefseqProtein = NP_005189
    | Hs_RefseqmRNA = NM_005198
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 49364260
    | Hs_GenLoc_end = 49368076
    | Hs_Uniprot = Q9Y259
    | Mm_EntrezGene = 12651
    | Mm_Ensembl = ENSMUSG00000022618
    | Mm_RefseqmRNA = NM_007692
    | Mm_RefseqProtein = NP_031718
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 89254134
    | Mm_GenLoc_end = 89257666
    | Mm_Uniprot = Q54AG5
  }}
}}
'''Choline kinase beta''', also known as '''CHKB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHKB choline kinase beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1120| accessdate = }}</ref>


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==External links==
{{PBB_Summary
* {{UCSC gene info|CHKB}}
| section_title =  
* {{UCSC gene info|CKB}}
| summary_text = Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.<ref name="entrez">{{cite web | title = Entrez Gene: CHKB choline kinase beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1120| accessdate = }}</ref>
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Aoyama C, Liao H, Ishidate K |title=Structure and function of choline kinase isoforms in mammalian cells. |journal=Prog. Lipid Res. |volume=43 |issue= 3 |pages= 266-81 |year= 2004 |pmid= 15003397 |doi= 10.1016/j.plipres.2003.12.001 }}
*{{cite journal  | vauthors=Aoyama C, Liao H, Ishidate K |title=Structure and function of choline kinase isoforms in mammalian cells |journal=Prog. Lipid Res. |volume=43 |issue= 3 |pages= 266–81 |year= 2004 |pmid= 15003397 |doi= 10.1016/j.plipres.2003.12.001 }}
*{{cite journal  | author=Ishidate K |title=Choline/ethanolamine kinase from mammalian tissues. |journal=Biochim. Biophys. Acta |volume=1348 |issue= 1-2 |pages= 70-8 |year= 1997 |pmid= 9370318 |doi=  }}
*{{cite journal  | author=Ishidate K |title=Choline/ethanolamine kinase from mammalian tissues |journal=Biochim. Biophys. Acta |volume=1348 |issue= 1-2 |pages= 70–8 |year= 1997 |pmid= 9370318 |doi=  10.1016/s0005-2760(97)00118-5}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  | vauthors=Collins JE, Wright CL, Edwards CA |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Hirosawa M, Nagase T, Murahashi Y, ''et al.'' |title=Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. |journal=DNA Res. |volume=8 |issue= 1 |pages= 1-9 |year= 2001 |pmid= 11258795 |doi=  }}
*{{cite journal  | vauthors=Hirosawa M, Nagase T, Murahashi Y |title=Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping |journal=DNA Res. |volume=8 |issue= 1 |pages= 1–9 |year= 2001 |pmid= 11258795 |doi=10.1093/dnares/8.1.1 |display-authors=etal}}
*{{cite journal  | author=Yamazaki N, Shinohara Y, Kajimoto K, ''et al.'' |title=Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31739-46 |year= 2000 |pmid= 10918069 |doi= 10.1074/jbc.M006322200 }}
*{{cite journal  | vauthors=Yamazaki N, Shinohara Y, Kajimoto K |title=Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31739–46 |year= 2000 |pmid= 10918069 |doi= 10.1074/jbc.M006322200 |display-authors=etal}}
*{{cite journal  | author=Aoyama C, Yamazaki N, Terada H, Ishidate K |title=Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta. |journal=J. Lipid Res. |volume=41 |issue= 3 |pages= 452-64 |year= 2000 |pmid= 10706593 |doi=  }}
*{{cite journal  | vauthors=Aoyama C, Yamazaki N, Terada H, Ishidate K |title=Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta |journal=J. Lipid Res. |volume=41 |issue= 3 |pages= 452–64 |year= 2000 |pmid= 10706593 |doi=  }}
*{{cite journal  | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295-308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
*{{cite journal  | vauthors=Loftus BJ, Kim UJ, Sneddon VP |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 |display-authors=etal}}
*{{cite journal  | author=Aoyama C, Nakashima K, Matsui M, Ishidate K |title=Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase. |journal=Biochim. Biophys. Acta |volume=1390 |issue= 1 |pages= 1-7 |year= 1998 |pmid= 9487136 |doi=  }}
*{{cite journal  | vauthors=Aoyama C, Nakashima K, Matsui M, Ishidate K |title=Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase |journal=Biochim. Biophys. Acta |volume=1390 |issue= 1 |pages= 1–7 |year= 1998 |pmid= 9487136 |doi=  10.1016/s0005-2760(97)00177-x}}
*{{cite journal  | author=Yamazaki N, Yamanaka Y, Hashimoto Y, ''et al.'' |title=Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I. |journal=FEBS Lett. |volume=409 |issue= 3 |pages= 401-6 |year= 1997 |pmid= 9224698 |doi=  }}
*{{cite journal  | vauthors=Yamazaki N, Yamanaka Y, Hashimoto Y |title=Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I |journal=FEBS Lett. |volume=409 |issue= 3 |pages= 401–6 |year= 1997 |pmid= 9224698 |doi=10.1016/S0014-5793(97)00561-9 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1120}}
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Revision as of 09:39, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Choline kinase beta is a protein encoded by the CHKB gene.[1][2] This gene is found on chromosome 22 in humans.[3]

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.[3]

References

  1. ↑ Yamazaki N, Yamanaka Y, Hashimoto Y, Shinohara Y, Shima A, Terada H (June 1997). "Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I". FEBS Lett. 409 (3): 401–6. doi:10.1016/S0014-5793(97)00561-9. PMID 9224698.
  2. ↑ Aoyama C, Liao H, Ishidate K (May 2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog. Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397.
  3. ↑ 3.0 3.1 "Entrez Gene: CHKB choline kinase beta".

External links

Further reading



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