CD200R1: Difference between revisions

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Revision as of 09:21, 30 August 2017

Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.^[1]^[2]^[3]

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.^[3]

References

↑ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (Sep 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.
↑ Dick AD, Broderick C, Forrester JV, Wright GJ (Jan 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Invest Ophthalmol Vis Sci. 42 (1): 170–6. PMID 11133863.
↑ ^3.0 ^3.1 "Entrez Gene: CD200R1 CD200 receptor 1".

Matsue H (2006). "CD 200-mediated regulation of skin immunity". J. Invest. Dermatol. 125 (6): x–xi. doi:10.1111/j.0022-202X.2005.23978.x. PMID 16354172.
Shiratori I, Yamaguchi M, Suzukawa M, et al. (2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". J. Immunol. 175 (7): 4441–9. doi:10.4049/jimmunol.175.7.4441. PMID 16177086.
Cherwinski HM, Murphy CA, Joyce BL, et al. (2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function". J. Immunol. 174 (3): 1348–56. doi:10.4049/jimmunol.174.3.1348. PMID 15661892.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Foster-Cuevas M, Wright GJ, Puklavec MJ, et al. (2004). "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor". J. Virol. 78 (14): 7667–76. doi:10.1128/JVI.78.14.7667-7676.2004. PMC 434103. PMID 15220441.
Karteris E, Chen J, Randeva HS (2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system". J. Clin. Endocrinol. Metab. 89 (4): 1957–62. doi:10.1210/jc.2003-031778. PMID 15070969.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Wright GJ, Cherwinski H, Foster-Cuevas M, et al. (2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200". J. Immunol. 171 (6): 3034–46. doi:10.4049/jimmunol.171.6.3034. PMID 12960329.
Vieites JM, de la Torre R, Ortega MA, et al. (2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13". Gene. 311: 99–104. doi:10.1016/S0378-1119(03)00562-6. PMID 12853143.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

CD200R1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CD200R1 genome location and CD200R1 gene details page in the UCSC Genome Browser.
Human HCRTR2 genome location and HCRTR2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid10981966-1] Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (Sep 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.

[pmid11133863-2] Dick AD, Broderick C, Forrester JV, Wright GJ (Jan 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Invest Ophthalmol Vis Sci. 42 (1): 170–6. PMID 11133863.

[entrez-3] 3.0 ^3.1 "Entrez Gene: CD200R1 CD200 receptor 1".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Cell surface glycoprotein CD200 receptor 1''' is a [[protein]] that in humans is encoded by the ''CD200R1'' [[gene]].<ref name="pmid10981966">{{cite journal | vauthors = Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN | title = Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function | journal = Immunity | volume = 13 | issue = 2 | pages = 233–42 |date=Sep 2000 | pmid = 10981966 | pmc =  | doi =10.1016/S1074-7613(00)00023-6  }}</ref><ref name="pmid11133863">{{cite journal | vauthors = Dick AD, Broderick C, Forrester JV, Wright GJ | title = Distribution of OX2 antigen and OX2 receptor within retina | journal = Invest Ophthalmol Vis Sci | volume = 42 | issue = 1 | pages = 170–6 |date=Jan 2001 | pmid = 11133863 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CD200R1 CD200 receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=131450| accessdate = }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = CD200 receptor 1
- | HGNCid = 24235
- | Symbol = CD200R1
- | AltSymbols =; HCRTR2; OX2R; CD200R; MOX2R
- | OMIM = 607546
- | ECnumber =
- | Homologene = 10957
-  | MGIid = 1889024
-  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 131450
-    | Hs_Ensembl = ENSG00000163606
-    | Hs_RefseqProtein = NP_620161
-    | Hs_RefseqmRNA = NM_138806
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 114122746
-    | Hs_GenLoc_end = 114176650
-    | Hs_Uniprot = Q8TD46
-    | Mm_EntrezGene = 57781
-    | Mm_Ensembl = ENSMUSG00000022667
-    | Mm_RefseqmRNA = NM_021325
-    | Mm_RefseqProtein = NP_067300
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 16
-    | Mm_GenLoc_start = 44685119
-    | Mm_GenLoc_end = 44714310
-    | Mm_Uniprot = Q9ES57
-  }}
-}}
-'''CD200 receptor 1''', also known as '''CD200R1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD200R1 CD200 receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=131450| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: CD200R1 CD200 receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=131450| accessdate = }}</ref>
+| summary_text = This gene encodes a receptor for the OX-2 membrane [[glycoprotein]]. Both the receptor and substrate are cell surface glycoproteins containing two [[immunoglobulin]]-like domains. This receptor is restricted to the surfaces of [[myeloid]] lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple [[transcript variant]]s.<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 61: / Line 16: @@
 | citations =
 *{{cite journal  | author=Matsue H |title=CD 200-mediated regulation of skin immunity. |journal=J. Invest. Dermatol. |volume=125 |issue= 6 |pages= x-xi |year= 2006 |pmid= 16354172 |doi= 10.1111/j.0022-202X.2005.23978.x }}
-*{{cite journal  | author=Shiratori I, Yamaguchi M, Suzukawa M, ''et al.'' |title=Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. |journal=J. Immunol. |volume=175 |issue= 7 |pages= 4441-9 |year= 2005 |pmid= 16177086 |doi=  }}
+*{{cite journal  | vauthors=Shiratori I, Yamaguchi M, Suzukawa M |title=Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. |journal=J. Immunol. |volume=175 |issue= 7 |pages= 4441–9 |year= 2005 |pmid= 16177086 |doi=  10.4049/jimmunol.175.7.4441|display-authors=etal}}
-*{{cite journal  | author=Cherwinski HM, Murphy CA, Joyce BL, ''et al.'' |title=The CD200 receptor is a novel and potent regulator of murine and human mast cell function. |journal=J. Immunol. |volume=174 |issue= 3 |pages= 1348-56 |year= 2005 |pmid= 15661892 |doi=  }}
+*{{cite journal  | vauthors=Cherwinski HM, Murphy CA, Joyce BL |title=The CD200 receptor is a novel and potent regulator of murine and human mast cell function. |journal=J. Immunol. |volume=174 |issue= 3 |pages= 1348–56 |year= 2005 |pmid= 15661892 |doi=  10.4049/jimmunol.174.3.1348|display-authors=etal}}
-*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
+*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504  | pmc=2286551 }}
-*{{cite journal  | author=Foster-Cuevas M, Wright GJ, Puklavec MJ, ''et al.'' |title=Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor. |journal=J. Virol. |volume=78 |issue= 14 |pages= 7667-76 |year= 2004 |pmid= 15220441 |doi= 10.1128/JVI.78.14.7667-7676.2004 }}
+*{{cite journal  | vauthors=Foster-Cuevas M, Wright GJ, Puklavec MJ |title=Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor. |journal=J. Virol. |volume=78 |issue= 14 |pages= 7667–76 |year= 2004 |pmid= 15220441 |doi= 10.1128/JVI.78.14.7667-7676.2004  | pmc=434103 |display-authors=etal}}
-*{{cite journal  | author=Karteris E, Chen J, Randeva HS |title=Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 4 |pages= 1957-62 |year= 2004 |pmid= 15070969 |doi=  }}
+*{{cite journal  | vauthors=Karteris E, Chen J, Randeva HS |title=Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 4 |pages= 1957–62 |year= 2004 |pmid= 15070969 |doi=10.1210/jc.2003-031778  }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
+*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 |display-authors=etal}}
-*{{cite journal  | author=Wright GJ, Cherwinski H, Foster-Cuevas M, ''et al.'' |title=Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. |journal=J. Immunol. |volume=171 |issue= 6 |pages= 3034-46 |year= 2003 |pmid= 12960329 |doi=  }}
+*{{cite journal  | vauthors=Wright GJ, Cherwinski H, Foster-Cuevas M |title=Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. |journal=J. Immunol. |volume=171 |issue= 6 |pages= 3034–46 |year= 2003 |pmid= 12960329 |doi=  10.4049/jimmunol.171.6.3034|display-authors=etal}}
-*{{cite journal  | author=Vieites JM, de la Torre R, Ortega MA, ''et al.'' |title=Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13. |journal=Gene |volume=311 |issue=  |pages= 99-104 |year= 2003 |pmid= 12853143 |doi=  }}
+*{{cite journal  | vauthors=Vieites JM, de la Torre R, Ortega MA |title=Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13. |journal=Gene |volume=311 |issue=  |pages= 99–104 |year= 2003 |pmid= 12853143 |doi=10.1016/S0378-1119(03)00562-6  |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Dick AD, Broderick C, Forrester JV, Wright GJ |title=Distribution of OX2 antigen and OX2 receptor within retina. |journal=Invest. Ophthalmol. Vis. Sci. |volume=42 |issue= 1 |pages= 170-6 |year= 2001 |pmid= 11133863 |doi=  }}
-*{{cite journal  | author=Wright GJ, Puklavec MJ, Willis AC, ''et al.'' |title=Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. |journal=Immunity |volume=13 |issue= 2 |pages= 233-42 |year= 2000 |pmid= 10981966 |doi=  }}
 }}
 {{refend}}
@@ Line 77: / Line 30: @@
 ==External links==
 * {{MeshName|CD200R1+protein,+human}}
+* {{UCSC gene info|CD200R1}}
+* {{UCSC gene info|HCRTR2}}
+{{NLM content}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 {{membrane-protein-stub}}
-{{NLM content}}
-{{WikiDoc Sources}}

CD200R1: Difference between revisions

Revision as of 09:21, 30 August 2017

References

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