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| {{drugbox
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| | IUPAC_name = 6-[3-(1-adamantyl)-4-methoxy-phenyl] naphthalene-2-carboxylic acid
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| | image = Adapalene.svg
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| | CAS_number = 106685-40-9
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| | ATC_prefix = D10
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| | ATC_suffix = AD03
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| | ATC_supplemental =
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| | PubChem = 60164
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| | DrugBank = APRD00780
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| | C=28|H=28|O=3
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| | molecular_weight = 412.52 g/mol
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| | bioavailability = Very low
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| | protein_bound =
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| | metabolism =
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| | excretion = [[Biliary]]
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| | elimination_half-life =
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| | pregnancy_category = C
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| | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S8 -->
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| | legal_UK = POM
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| | legal_US = Rx-only
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| | routes_of_administration = [[Topical]]
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| }}
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| '''Adapalene''' is a topical [[retinoid]] primarily used in the treatment of [[Acne vulgaris|acne]] and is also used ([[off-label use|off-label]]) to treat [[keratosis pilaris]] as well as other skin conditions.<ref>{{cite journal | author = Rolewski S | title = Clinical review: topical retinoids. | journal = Dermatol Nurs | volume = 15 | issue = 5 | pages = 447-50, 459-65 | year = 2003 | id = PMID 14619325 | url = http://www.medscape.com/viewarticle/464026}}</ref> It is currently marketed by [[Galderma Laboratories|Galderma]] under the trade names '''Differin®''' in some countries, and '''Adaferin®''' in India.
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| == Indications ==
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| Adapalene is indicated for the topical treatment of acne vulgaris.
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| Adapalene has been shown to enhance the efficacity of topical [[clindamycin]].
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| Application of Adapalene gel to the skin 2-5 minutes before application of clindamycin enhances the overall efficacity of the treatment as compared to clindamycin alone
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| == History ==
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| Adapalene was approved in [[1996]] by the U.S. [[Food and Drug Administration]] for use in the treatment of acne.
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| ==Dosage==
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| Adapalene is applied once daily, after washing and before retiring. In some circumstances, when a patient complains of skin irritation, this may be decreased to once every other day until the irritation ceases.
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| ==Available Forms==
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| [[Differin]] is available in two forms, 0.1% adapalene and now the newer 0.3% adapalene (as of July 07)
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| == Pharmacology ==
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| === Pharmacodynamics ===
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| Adapalene in small concentrations is a moderator of [[cellular differentiation]], [[keratinization]], and inflammatory processes. The exact mode of action of adapalene is unknown.
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| === Pharmacokinetics ===
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| Adapalene is applied topically to the skin, and its absorption into the blood through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.
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| == External links ==
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| * [http://www.differin.com/AboutDifferin/ProductInsert.aspx Differin product insert]
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| ==References==
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| {{reflist|2}}
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| {{Acne Agents}}
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| [[Category:Dermatological preparations]]
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| [[Category:Retinoids]]
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| [[Category:Carboxylic acids]]
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| [[Category:Aromatic compounds]]
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| [[de:Adapalen]]
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| [[fr:Adapalène]]
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| [[ja:アダパレン]]
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| [[pl:Adapalen]]
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| [[pt:Adapaleno]]
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