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{{Infobox_gene}}
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'''ATP-binding cassette sub-family B member 9''' is a [[protein]] that in humans is encoded by the ''ABCB9'' [[gene]].<ref name="pmid8894702">{{cite journal | vauthors = Allikmets R, Gerrard B, Hutchinson A, Dean M | title = Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. | journal = Hum Mol Genet | volume = 5 | issue = 10 | pages = 1649–55 |date=Feb 1997 | pmid = 8894702 | pmc =  | doi =10.1093/hmg/5.10.1649 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23457| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = ATP-binding cassette, sub-family B (MDR/TAP), member 9
| HGNCid = 50
| Symbol = ABCB9
| AltSymbols =; EST122234; KIAA1520; TAPL
| OMIM = 605453
| ECnumber = 
| Homologene = 10491
| MGIid = 1861729
| GeneAtlas_image1 = PBB_GE_ABCB9_214209_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ABCB9_207321_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015198 |text = oligopeptide transporter activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0043190 |text = ATP-binding cassette (ABC) transporter complex}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006857 |text = oligopeptide transport}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23457
    | Hs_Ensembl = ENSG00000150967
    | Hs_RefseqProtein = NP_062570
    | Hs_RefseqmRNA = NM_019624
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 121979500
    | Hs_GenLoc_end = 122032149
    | Hs_Uniprot = Q9NP78
    | Mm_EntrezGene = 56325
    | Mm_Ensembl = ENSMUSG00000029408
    | Mm_RefseqmRNA = NM_019875
    | Mm_RefseqProtein = NP_063928
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 124322151
    | Mm_GenLoc_end = 124356393
    | Mm_Uniprot = Q9JJ59
  }}
}}
'''ATP-binding cassette, sub-family B (MDR/TAP), member 9''', also known as '''ABCB9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23457| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specifications.<ref name="entrez">{{cite web | title = Entrez Gene: ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23457| accessdate = }}</ref>
| summary_text = The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. [[Alternative splicing]] of this gene results in distinct [[protein isoforms|isoforms]] which are likely to have different substrate specifications.<ref name="entrez"/>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Allikmets R, Gerrard B, Hutchinson A, Dean M |title=Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. |journal=Hum. Mol. Genet. |volume=5 |issue= 10 |pages= 1649-55 |year= 1997 |pmid= 8894702 |doi= }}
*{{cite journal  | vauthors=Zhang F, Zhang W, Liu L |title=Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23287–94 |year= 2000 |pmid= 10748049 |doi= 10.1074/jbc.M001819200 |display-authors=etal}}
*{{cite journal  | author=Zhang F, Zhang W, Liu L, ''et al.'' |title=Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23287-94 |year= 2000 |pmid= 10748049 |doi= 10.1074/jbc.M001819200 }}
*{{cite journal  | vauthors=Nagase T, Kikuno R, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=10.1093/dnares/7.2.143 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Kikuno R, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143-50 |year= 2000 |pmid= 10819331 |doi=  }}
*{{cite journal  | vauthors=Kobayashi A, Kasano M, Maeda T |title=A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2. |journal=J. Biochem. |volume=128 |issue= 4 |pages= 711–8 |year= 2000 |pmid= 11011155 |doi=  10.1093/oxfordjournals.jbchem.a022805|display-authors=etal}}
*{{cite journal  | author=Kobayashi A, Kasano M, Maeda T, ''et al.'' |title=A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2. |journal=J. Biochem. |volume=128 |issue= 4 |pages= 711-8 |year= 2000 |pmid= 11011155 |doi=  }}
*{{cite journal  | vauthors=Saito S, Iida A, Sekine A |title=Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. |journal=J. Hum. Genet. |volume=47 |issue= 1 |pages= 38–50 |year= 2002 |pmid= 11829140 |doi=10.1007/s10038-002-8653-6 |display-authors=etal}}
*{{cite journal  | author=Saito S, Iida A, Sekine A, ''et al.'' |title=Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. |journal=J. Hum. Genet. |volume=47 |issue= 1 |pages= 38-50 |year= 2002 |pmid= 11829140 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Kobayashi A, Hori S, Suita N, Maeda M |title=Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 4 |pages= 815–22 |year= 2003 |pmid= 13679046 |doi=10.1016/j.bbrc.2003.08.081 }}
*{{cite journal  | author=Kobayashi A, Hori S, Suita N, Maeda M |title=Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity. |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 4 |pages= 815-22 |year= 2003 |pmid= 13679046 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Homma K, Kikuno RF, Nagase T |title=Alternative splice variants encoding unstable protein domains exist in the human brain |journal=J. Mol. Biol. |volume=343 |issue= 5 |pages= 1207–20 |year= 2004 |pmid= 15491607 |doi= 10.1016/j.jmb.2004.09.028 |display-authors=etal}}
*{{cite journal  | author=Homma K, Kikuno RF, Nagase T, ''et al.'' |title=Alternative splice variants encoding unstable protein domains exist in the human brain. |journal=J. Mol. Biol. |volume=343 |issue= 5 |pages= 1207-20 |year= 2004 |pmid= 15491607 |doi= 10.1016/j.jmb.2004.09.028 }}
*{{cite journal  | vauthors=Wolters JC, Abele R, Tampé R |title=Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9) |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 23631–6 |year= 2005 |pmid= 15863492 |doi= 10.1074/jbc.M503231200 }}
*{{cite journal  | author=Wolters JC, Abele R, Tampé R |title=Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9). |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 23631-6 |year= 2005 |pmid= 15863492 |doi= 10.1074/jbc.M503231200 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | vauthors=Ohashi-Kobayashi A, Ohashi K, Du WB |title=Examination of drug resistance activity of human TAP-like (ABCB9) expressed in yeast |journal=Biochem. Biophys. Res. Commun. |volume=343 |issue= 2 |pages= 597–601 |year= 2006 |pmid= 16554024 |doi= 10.1016/j.bbrc.2006.03.002 |display-authors=etal}}
*{{cite journal  | author=Ohashi-Kobayashi A, Ohashi K, Du WB, ''et al.'' |title=Examination of drug resistance activity of human TAP-like (ABCB9) expressed in yeast. |journal=Biochem. Biophys. Res. Commun. |volume=343 |issue= 2 |pages= 597-601 |year= 2006 |pmid= 16554024 |doi= 10.1016/j.bbrc.2006.03.002 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|ABCB9+protein,+human}}
* {{MeshName|ABCB9+protein,+human}}
* {{UCSC gene info|ABCB9}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{ABC transporters}}
 
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{{DEFAULTSORT:Abcb9}}
[[Category:ABC transporters]]
[[Category:ABC transporters]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 17:38, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ATP-binding cassette sub-family B member 9 is a protein that in humans is encoded by the ABCB9 gene.[1][2]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specifications.[2]

See also

References

  1. ↑ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  2. ↑ 2.0 2.1 "Entrez Gene: ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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