CYP2W1: Difference between revisions

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{{protein
{{Infobox_gene}}
|Name=Cytochrome P450, family 2, subfamily W, polypeptide 1
|caption=
|image=
|width=
|HGNCid=20243
|Symbol=CYP2W1
|AltSymbols=
|EntrezGene=54905
|OMIM=
|RefSeq=NM_017781
|UniProt= Q8TAV3
|PDB=
|ECnumber=
|Chromosome=7
|Arm=p
|Band=22.3
|LocusSupplementaryData=
}}
{{SI}}


'''CYP2W1''' ('''cy'''tochrome '''P'''450, family '''2''', subfamily '''W''', polypeptide '''1''') is a [[protein]] that in humans is encoded by the ''CYP2W1'' [[gene]].<ref name="pmid15489334">{{cite journal | vauthors = Gerhard DS, Wagner L, Feingold EA | title = The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2121–7 |date=October 2004 | pmid = 15489334 | pmc = 528928 | doi = 10.1101/gr.2596504 | url =  |display-authors=etal}}</ref>


'''CYP2W1''' ('''cy'''tochrome '''P'''450, family '''2''', subfamily '''W''', polypeptide '''1''') is a [[protein]] which in humans is encoded by the ''CYP2W1'' [[gene]].<ref name="pmid15489334">{{cite journal | author = Gerhard DS, Wagner L, Feingold EA, ''et al'' | title = The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2121–7 | year = 2004 | month = October | pmid = 15489334 | pmc = 528928 | doi = 10.1101/gr.2596504 | url = | issn = }}</ref>
This gene encodes a member of the [[cytochrome P450]] superfamily of [[enzyme]]s. The cytochrome P450 proteins are [[monooxygenase]]s which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.<ref name="entrez_2532">{{cite web | title = Entrez Gene: CYP2W1 | url =https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54905 | accessdate = }}</ref> CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.


This gene encodes a member of the [[cytochrome P450]] superfamily of [[enzyme]]s. The cytochrome P450 proteins are [[monooxygenase]]s which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.<ref name="entrez_2532">{{cite web | title = Entrez Gene: CYP2W1 | url =http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54905 | accessdate = }}</ref>
==References==
==References==
{{Reflist}}
{{Reflist}}
==External links==
* {{UCSC gene info|CYP2W1}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899  |pmc=139241 |display-authors=etal}}
*{{cite journal  |vauthors=Hanzawa Y, Sasaki T, Mizugaki M |title=Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population |journal=Drug Metab. Dispos. |volume=36 |issue= 2 |pages= 349–52 |year= 2008 |pmid= 17998294 |doi= 10.1124/dmd.107.019141 |display-authors=etal}}
*{{cite journal  |vauthors=Yoshioka H, Kasai N, Ikushiro S |title=Enzymatic properties of human CYP2W1 expressed in Escherichia coli |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 1 |pages= 169–74 |year= 2006 |pmid= 16677611 |doi= 10.1016/j.bbrc.2006.04.080 |display-authors=etal}}
*{{cite journal  |vauthors=Karlgren M, Gomez A, Stark K |title=Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1 |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 2 |pages= 451–8 |year= 2006 |pmid= 16426568 |doi= 10.1016/j.bbrc.2005.12.200 |display-authors=etal}}
*{{cite journal  |vauthors=Gomez A, Karlgren M, Edler D |title=Expression of CYP2W1 in colon tumors: regulation by gene methylation |journal=Pharmacogenomics |volume=8 |issue= 10 |pages= 1315–25 |year= 2007 |pmid= 17979506 |doi= 10.2217/14622416.8.10.1315 |display-authors=etal}}
*{{cite journal  |vauthors=Nelson DR, Zeldin DC, Hoffman SM |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1–18 |year= 2004 |pmid= 15128046 |doi=10.1097/00008571-200401000-00001  |display-authors=etal}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{Cytochrome P450}}
{{Cytochrome P450}}




{{WH}}
{{gene-7-stub}}
{{WS}}

Latest revision as of 10:15, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.[2] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.

References

  1. ↑ Gerhard DS, Wagner L, Feingold EA, et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  2. ↑ "Entrez Gene: CYP2W1".

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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