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==References==
==References==
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==Further reading==
==Further reading==
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Revision as of 15:15, 4 September 2012


Cytochrome P450, family 2, subfamily F, polypeptide 1
Identifiers
Symbols CYP2F1 ; C2F1; CYP2F; MGC126121
External IDs Template:OMIM5 Template:MGI HomoloGene73898
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

WikiDoc Resources for CYP2F1

Articles

Most recent articles on CYP2F1

Most cited articles on CYP2F1

Review articles on CYP2F1

Articles on CYP2F1 in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on CYP2F1

Images of CYP2F1

Photos of CYP2F1

Podcasts & MP3s on CYP2F1

Videos on CYP2F1

Evidence Based Medicine

Cochrane Collaboration on CYP2F1

Bandolier on CYP2F1

TRIP on CYP2F1

Clinical Trials

Ongoing Trials on CYP2F1 at Clinical Trials.gov

Trial results on CYP2F1

Clinical Trials on CYP2F1 at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on CYP2F1

NICE Guidance on CYP2F1

NHS PRODIGY Guidance

FDA on CYP2F1

CDC on CYP2F1

Books

Books on CYP2F1

News

CYP2F1 in the news

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Commentary

Blogs on CYP2F1

Definitions

Definitions of CYP2F1

Patient Resources / Community

Patient resources on CYP2F1

Discussion groups on CYP2F1

Patient Handouts on CYP2F1

Directions to Hospitals Treating CYP2F1

Risk calculators and risk factors for CYP2F1

Healthcare Provider Resources

Symptoms of CYP2F1

Causes & Risk Factors for CYP2F1

Diagnostic studies for CYP2F1

Treatment of CYP2F1

Continuing Medical Education (CME)

CME Programs on CYP2F1

International

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Patents on CYP2F1

Experimental / Informatics

List of terms related to CYP2F1

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Cytochrome P450, family 2, subfamily F, polypeptide 1, also known as CYP2F1, is a human gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.[1]

References

  1. 1.0 1.1 "Entrez Gene: CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1".

Further reading

  • Nhamburo PT, Kimura S, McBride OW; et al. (1990). "The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping". Biochemistry. 29 (23): 5491–9. PMID 1974816.
  • Bale AE, Mitchell AL, Gonzalez FJ, McBride OW (1991). "Localization of CYP2F1 by multipoint linkage analysis and pulsed-field gel electrophoresis". Genomics. 10 (1): 284–6. PMID 2045106.
  • Trask B, Fertitta A, Christensen M; et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. PMID 8432525.
  • Hoffman SM, Fernandez-Salguero P, Gonzalez FJ, Mohrenweiser HW (1996). "Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19". J. Mol. Evol. 41 (6): 894–900. PMID 8587134.
  • Hakkola J, Pasanen M, Hukkanen J; et al. (1996). "Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta". Biochem. Pharmacol. 51 (4): 403–11. PMID 8619884.
  • Andersen MR, Farin FM, Omiecinski CJ (1998). "Quantification of multiple human cytochrome P450 mRNA molecules using competitive reverse transcriptase-PCR". DNA Cell Biol. 17 (3): 231–8. PMID 9539103.
  • Lanza DL, Code E, Crespi CL; et al. (1999). "Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells". Drug Metab. Dispos. 27 (7): 798–803. PMID 10383923.
  • Chen N, Whitehead SE, Caillat AW; et al. (2002). "Identification and cross-species comparisons of CYP2F subfamily genes in mammals". Mutat. Res. 499 (2): 155–61. PMID 11827709.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Carr BA, Wan J, Hines RN, Yost GS (2003). "Characterization of the human lung CYP2F1 gene and identification of a novel lung-specific binding motif". J. Biol. Chem. 278 (18): 15473–83. doi:10.1074/jbc.M300319200. PMID 12598524.
  • Tournel G, Cauffiez C, Billaut-Laden I; et al. (2007). "Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant". Mutat. Res. 617 (1–2): 79–89. doi:10.1016/j.mrfmmm.2007.01.007. PMID 17327131.


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