Anti-NMDA receptor encephalitis causes: Difference between revisions

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<ref name="pmid24360484">{{cite journal| author=Gresa-Arribas N, Titulaer MJ, Torrents A, Aguilar E, McCracken L, Leypoldt F | display-authors=etal| title=Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. | journal=Lancet Neurol | year= 2014 | volume= 13 | issue= 2 | pages= 167-77 | pmid=24360484 | doi=10.1016/S1474-4422(13)70282-5 | pmc=4006368 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24360484  }} </ref>
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Revision as of 07:11, 13 May 2023

Anti-NMDA receptor encephalitis Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; AE Dheeraj Makkar, M.D.[2]

Overview

Causes

Antibodies and the tumors producing them
Antibodies Antigens Associated symptoms Tumors
Anti-Hu (ANNA-1) HuD Encephalomyelitis, limbic encephalitis, cerebellar degeneration, brain stem encephalitis, multi-segmental myelitis, sensory neuronopathy, sensory motor neuropathy, autonomic neuropathy Lung cancer (85%), mostly SCLC, neuroblastoma, prostate carcinoma
Anti-Yo (PCA-1) CDR2, CDR62 Paraneoplastic cerebellar degeneration Ovarian, breast cancer
Anti-CV2(CRMP5) CRMP5 Encephalomyelitis, polyneuropathy, optic neuritis, limbic encephalitis, choreatic syndromes, cerebellar degeneration SCLC, thymoma
Anti-Ta/Ma2 MA-proteins Limbic encephalitis, rhombencephalitis, male>>female Testicular cancer
Anti-Ri (ANNA-2) NOVA-1 Opsoclonus–myoclonus syndrome, rhombencephalitis, cerebellar degeneration, myelitis, jaw dystonia, laryngospasm Breast, ovarian carcinoma, SCLC
Anti-amphiphysin Amphiphysin Stiff-person syndrome, limbic encephalitis, rhombencephalitis, cerebellar degeneration, polyneuropathy Breast cancer, SCLC
Anti-recoverin Recoverin Retinopathy SCLC
Anti-SOX-1 (AGNA) SOX-1 Non-syndrome-specific Sensitivity 67%, specificity 95% for SCLC in LEMS
Partially characterized onconeural antibodies (antigen not characterized or positive predictive value for tumor unknown)
Antibodies Antigens Associated symptoms Tumors
Anti-Tr (PCA-Tr) DNER Cerebellar degeneration Hodgkin lymphoma, non-Hodgkin lymphoma
Anti-Zic4 ZIC1-4 Cerebellar degeneration SCLC
PCA-2 280 kD Encephalitis, Lambert–Eaton myasthenic syndrome, polyneuropathy SCLC
ANNA-3 170 kD Neuropathy, cerebellar degeneration, limbic encephalitis SCLC

SCLC: Small cell lung carcinoma; LEMS: Lambert–Eaton myasthenic syndrome (LEMS) DNER: delta/notch-like epidermal growth factor-related receptor

References

[1] Template:WH Template:WS

  1. Gresa-Arribas N, Titulaer MJ, Torrents A, Aguilar E, McCracken L, Leypoldt F; et al. (2014). "Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study". Lancet Neurol. 13 (2): 167–77. doi:10.1016/S1474-4422(13)70282-5. PMC 4006368. PMID 24360484.