Fever of unknown origin differential diagnosis: Difference between revisions

Jump to navigation Jump to search
Line 146: Line 146:
*
*
|-
|-
|
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|
| style="padding: 5px 5px; background: #F5F5F5;" |
|
*
|
*
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
*
*
*
|-
|-
|
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|
| style="padding: 5px 5px; background: #F5F5F5;" |
|
*
|
*
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
*
*
*
|-
|-
|
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|
| style="padding: 5px 5px; background: #F5F5F5;" |
|
*
|
*
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
*
*
*
|-
|-
|
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|
| style="padding: 5px 5px; background: #F5F5F5;" |
|
*
|
*
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
*
*
| style="padding: 5px 5px; background: #F5F5F5;" |
*
*
*
|-
 
|}
|}



Revision as of 15:50, 9 February 2021

Resident
Survival
Guide

Fever of unknown origin Microchapters

Home

Patient Information

Overview

Historical perspective

Pathophysiology

Causes

Differentiating Fever of unknown origin from other Diseases

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

Diagnostic study of choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and ultrasound

CT scan

MRI

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Fever of unknown origin differential diagnosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Fever of unknown origin differential diagnosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Fever of unknown origin differential diagnosis

CDC on Fever of unknown origin differential diagnosis

Fever of unknown origin differential diagnosis in the news

Blogs on Fever of unknown origin differential diagnosis

Directions to Hospitals Treating Fever of unknown origin

Risk calculators and risk factors for Fever of unknown origin differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; FUO; PUO; pyrexia of unknown origin

Overview

  1. Fever can be the presenting symptom with many diseases, it is therefore important to differentiate fever of unknown origin from all those diseases which present with fever.
  2. Because of the broad range of differential diagnosis they can be grouped into four categories based on their etiology.

Differential diagnosis

Infectious

These patients mostly have a history of hospitalization, surgical procedures, contact with infected person or travel to an endemic place.[2][3]

Examples include:

Malignant

They are mostly accompanied by loss of weight, decrease in appetite, lymph node enlargement and aquagenic pruritic mostly occurring after hot shower.

Examples include:

Autoinflammatory/Rheumatologic

Mostly they have multi organ involvement and lymphadenopathy along with joint symptoms may be present.[4][5]

Examples include:


Miscellaneous

Mostly does not belong to any of the above.

Examples include:


Disease History Physical examination Laboratory or radiological findings
Subacute Bacterial endocartitis Recent dental procedures, Joint pain, decrease weight, Night sweats, back pain
Heart murmur, splinter hemorrhages, Janeway lesions, Roth spots, enlarged spleen.
Elevated WBCs, decreased platelets, Elevated ESR , presence of Cryoglobulins
Abscess GI, genitourinary, Pelvic procedure or infection , fever, chills, decrease weight, night sweats.
RUQ tenderness ( subphrenic Abscess),hepatomegaly (hepatic abscess), splenomegaly ( splenic abscess), tenderness on DRE ( pelvic abscess).
Elevated WBCs and ESR, elevated platelets, Positive CT/MRI findings
Tuberculosis of CNS Previous tuberculosis, Altered mental status, Headace
Morning temperature spikes, relative bradycardia, Abducens palsy.
CSF: Increased lymphocytes, increased RBCs, decreased glucose, increased lactate, positive AFB stain and Culture.
EBV infection Exposure to saliva ( kissing disease ) , upper respiratory tract infection
Enlarged lymph nodes, palatal petechiae, enlarged tonsils, enlarged spleen.
Decreased WBCs, decreased lymphocytes, atypical lymphocytosis, positive PCR, positive IgM EBV VCA titers, enlarged spleen, increased LFTs.

References

  1. Cunha, Burke A.; Lortholary, Olivier; Cunha, Cheston B. (2015). "Fever of Unknown Origin: A Clinical Approach". The American Journal of Medicine. 128 (10): 1138.e1–1138.e15. doi:10.1016/j.amjmed.2015.06.001. ISSN 0002-9343.
  2. Cunha, Burke A.; Lortholary, Olivier; Cunha, Cheston B. (2015). "Fever of Unknown Origin: A Clinical Approach". The American Journal of Medicine. 128 (10): 1138.e1–1138.e15. doi:10.1016/j.amjmed.2015.06.001. ISSN 0002-9343.
  3. Salzberger B, Schneidewind A, Hanses F, Birkenfeld G, Müller-Schilling M (2012). "[Fever of unknown origin. Infectious causes]". Internist (Berl). 53 (12): 1445–53, quiz 1454-5. doi:10.1007/s00108-012-3173-8. PMID 23111594.
  4. Kümmerle-Deschner JB (2017). "[Autoinflammatory Diseases as a Differential Diagnosis of Fever of Unknown Origin]". Dtsch Med Wochenschr. 142 (13): 969–978. doi:10.1055/s-0043-103468. PMID 28672419.
  5. Mulders-Manders CM, Simon A, Bleeker-Rovers CP (2016). "Rheumatologic diseases as the cause of fever of unknown origin". Best Pract Res Clin Rheumatol. 30 (5): 789–801. doi:10.1016/j.berh.2016.10.005. PMID 27964789.

Template:WH Template:WS


References