Pseudomyxoma peritonei causes: Difference between revisions
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*Studies have shown and supported the fact that pseudomyxoma peritonei arises from primary appendiceal neoplasm rather than ovarian or colon origin.<ref name="pmid22718846">{{cite journal |vauthors=Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T, Moran B |title=Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases |journal=J. Clin. Pathol. |volume=65 |issue=10 |pages=919–23 |date=October 2012 |pmid=22718846 |doi=10.1136/jclinpath-2012-200843 |url=}}</ref> | *Studies have shown and supported the fact that pseudomyxoma peritonei arises from primary appendiceal neoplasm rather than ovarian or colon origin.<ref name="pmid22718846">{{cite journal |vauthors=Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T, Moran B |title=Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases |journal=J. Clin. Pathol. |volume=65 |issue=10 |pages=919–23 |date=October 2012 |pmid=22718846 |doi=10.1136/jclinpath-2012-200843 |url=}}</ref> | ||
*The primary tumor appears to arise from the [[MUC2]] expressing [[goblet cell]]s and most commonly from these cells in the appendix. | *The primary tumor appears to arise from the [[MUC2]] expressing [[goblet cell]]s and most commonly from these cells in the appendix. | ||
*The K-Ras and ''[[p53]]'' genes may be involved in the oncogenesis. | *The K-Ras and ''[[p53]]'' genes may be involved in the oncogenesis. | ||
*While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas, other conditions may also be found, including disseminated peritoneal adenomucinosis (DPAM), peritoneal carcinomas, or several [[mucinous]] tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma).<ref name="Jacquemin_2005">{{cite journal |author=Jacquemin G, Laloux P |title=Pseudomyxoma peritonei: review on a cluster of peritoneal mucinous diseases |journal=Acta Chir Belg |volume=105 |issue=2 |pages=127–33 |year=2005 |pmid=15906901}}</ref> | *While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas, other conditions may also be found, including disseminated peritoneal adenomucinosis (DPAM), peritoneal carcinomas, or several [[mucinous]] tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma).<ref name="Jacquemin_2005">{{cite journal |author=Jacquemin G, Laloux P |title=Pseudomyxoma peritonei: review on a cluster of peritoneal mucinous diseases |journal=Acta Chir Belg |volume=105 |issue=2 |pages=127–33 |year=2005 |pmid=15906901}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pseudomyxoma peritonei is caused by a pre-existing intraperitoneal mucinous neoplasm. The K-Ras and p53 genes may be involved in the oncogenesis.
Causes
- Since initial descriptions of pseudomyxoma peritonei as a syndrome in association with an ovarian tumor or an appendiceal mucocele, a pre-existing intraperitoneal mucinous neoplasm, mostly appendiceal tumor has been implicated as the primary cause of pseudomyxoma peritonei.
- Studies have shown and supported the fact that pseudomyxoma peritonei arises from primary appendiceal neoplasm rather than ovarian or colon origin.[1]
- The primary tumor appears to arise from the MUC2 expressing goblet cells and most commonly from these cells in the appendix.
- The K-Ras and p53 genes may be involved in the oncogenesis.
- While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas, other conditions may also be found, including disseminated peritoneal adenomucinosis (DPAM), peritoneal carcinomas, or several mucinous tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma).[2]
References
- ↑ Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T, Moran B (October 2012). "Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases". J. Clin. Pathol. 65 (10): 919–23. doi:10.1136/jclinpath-2012-200843. PMID 22718846.
- ↑ Jacquemin G, Laloux P (2005). "Pseudomyxoma peritonei: review on a cluster of peritoneal mucinous diseases". Acta Chir Belg. 105 (2): 127–33. PMID 15906901.