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**Simple cyst
**Simple cyst
**Fibrosis
**Fibrosis
*** Fibroadenoma (simple)
** Fibroadenoma (simple)
**** Columnar alteration (Simple)
** Columnar alteration (Simple)
***** Apocrine metaplasia (simple)
** Apocrine metaplasia (simple)
****** Mild ductal hyperplasia  
** Mild ductal hyperplasia  
** Approximately 30% of total are classifed as [[proliferative disease(PD) with relative cancer risk of 1.7, 2.1 times
* Approximately 30% of total are classifed as [[proliferative disease(PD) with relative cancer risk of 1.7, 2.1 times
** Usual ductal hyperplasia
** Usual ductal hyperplasia
***  Sclerosing adenosis
**  Sclerosing adenosis
**** Columnar hyperplasia  
** Columnar hyperplasia  
      ***** papilloma
** papilloma
      ****** Radical scar
** Radical scar
  *** Approximately 5% to 8% of the rest regarded to [[PD with atypia]]with relative cancer risk more than 4 times
* Approximately 5% to 8% of the rest regarded to [[PD with atypia]]with relative cancer risk more than 4 times
      *** Atypical lobar hyperplasia
** Atypical lobar hyperplasia
      **** Lobular carcinoma in situ
** Lobular carcinoma in situ
      ***** Atypical ductal hyperplasia
** Atypical ductal hyperplasia
**** Unclear risk
* Unclear risk
      **** Mucocele like tumor
** Mucocele like tumor
      ***** Apocrine atypia
** Apocrine atypia
      ****** Secretory atypia
** Secretory atypia


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 16:20, 6 December 2018


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]

Overview

Classification

Classification of breast lumps based on epithelial hyperplasia[1]

  • Approximately 65% of all BBD considered as nonproliferative(NP)with relative cancer risk of 1.2, 1.4 times:
    • Simple cyst
    • Fibrosis
    • Fibroadenoma (simple)
    • Columnar alteration (Simple)
    • Apocrine metaplasia (simple)
    • Mild ductal hyperplasia
  • Approximately 30% of total are classifed as [[proliferative disease(PD) with relative cancer risk of 1.7, 2.1 times
    • Usual ductal hyperplasia
    • Sclerosing adenosis
    • Columnar hyperplasia
    • papilloma
    • Radical scar
  • Approximately 5% to 8% of the rest regarded to PD with atypiawith relative cancer risk more than 4 times
    • Atypical lobar hyperplasia
    • Lobular carcinoma in situ
    • Atypical ductal hyperplasia
  • Unclear risk
    • Mucocele like tumor
    • Apocrine atypia
    • Secretory atypia

References

  1. Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K; et al. (2005). "Benign breast disease and the risk of breast cancer". N Engl J Med. 353 (3): 229–37. doi:10.1056/NEJMoa044383. PMID 16034008.