Hemoglobinopathy: Difference between revisions

Revision as of 16:18, 31 August 2018

Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule. Most common hemoglobinopathies include sickle-cell disease.

Hemoglobinopathy be classified according to genetic and structure of hemoglobin into two main groups:

The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.

In 2008, the prevalence of hemoglobinopathy was estimated to be 7% of the worldwide population being carrier.

α-thalassemias

It occure cur mainly in Africa, Arab nations, and, more frequently and South-East Asia

β-thalassemias

It occure cur mainly in Mediterranean countries, South-East Europe, Arab nations and Asia.

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 ==Classification==
-Hemoglobinopathy be classified according to genetic and structure of hemoglobin into two main groups:<ref name="pmid17950634">{{cite journal |vauthors=Petrides PE, Beykirch MK, Kohne E |title=The high oxygen-affinity Hemoglobin Johnstown [(beta 109(G11) Val-->Leu] in a German kindred with an elevated erythrocyte hemoglobin content: potential interaction with HFE mutations |journal=Blood Cells Mol. Dis. |volume=40 |issue=2 |pages=180–2 |date=2008 |pmid=17950634 |doi=10.1016/j.bcmd.2007.08.007 |url=}}</ref>
+Hemoglobinopathy be classified according to genetic and structure of hemoglobin into two main groups:
 * Thalassemia syndromes
 **α-thalassemia
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 ===Race===
 '''α-thalassemias'''
 It occure cur mainly in Africa, Arab nations, and, more frequently and South-East Asia
 '''β-thalassemias'''
 It occure cur mainly in Mediterranean countries, South-East Europe, Arab nations and Asia.
+===Screening===
 == Common variants ==
 * Hb S