Hemoglobinopathy: Difference between revisions
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==Overview== | ==Overview== | ||
'''Hemoglobinopathy''' is a kind of [[gene]]tic defect that results in [[abnormal]] structure of one of the [[globin]] [[chain]]<nowiki/>s of the [[hemoglobin]] [[molecule]]. Most common hemoglobinopathies include [[sickle-cell disease]]. | '''Hemoglobinopathy''' is a kind of [[gene]]tic defect that results in [[abnormal]] structure of one of the [[globin]] [[chain]]<nowiki/>s of the [[hemoglobin]] [[molecule]]. Most common hemoglobinopathies include [[sickle-cell disease]]. | ||
== | ==Classification== | ||
Common symptoms of hemoglobinopathy include: | Common symptoms of hemoglobinopathy include: | ||
*Skeletal deformitie | *Skeletal deformitie | ||
*Tumorous masses | *Tumorous masses | ||
Hemoglobinopathy be classified according to genetic and structural of hemoglobin into two main groups:<ref name="pmid21886666">{{cite journal |vauthors=Kohne E |title=Hemoglobinopathies: clinical manifestations, diagnosis, and treatment |journal=Dtsch Arztebl Int |volume=108 |issue=31-32 |pages=532–40 |date=August 2011 |pmid=21886666 |pmc=3163784 |doi=10.3238/arztebl.2011.0532 |url=}}</ref> | |||
* Thalassemia syndromes | |||
* structural hemoglobin variants | |||
OR | |||
[Disease name] may be classified into [large number > 6] subtypes based on: | |||
* [Classification method 1] | |||
* [Classification method 2] | |||
* [Classification method 3] | |||
[Disease name] may be classified into several subtypes based on: | |||
* [Classification method 1] | |||
* [Classification method 2] | |||
* [Classification method 3] | |||
OR | |||
Based on the duration of symptoms, [disease name] may be classified as either acute or chronic. | |||
OR | |||
'''If the staging system involves specific and characteristic findings and features:''' | |||
According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2]. | |||
OR | |||
The staging of [malignancy name] is based on the [staging system]. | |||
OR | |||
There is no established system for the staging of [malignancy name]. | |||
== Migration patterns == | == Migration patterns == | ||
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[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Mature chapter]] | [[Category:Mature chapter]] | ||
<references /> | |||
Revision as of 17:59, 30 August 2018
Template:Search infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule. Most common hemoglobinopathies include sickle-cell disease.
Classification
Common symptoms of hemoglobinopathy include:
- Skeletal deformitie
- Tumorous masses
Hemoglobinopathy be classified according to genetic and structural of hemoglobin into two main groups:[1]
- Thalassemia syndromes
- structural hemoglobin variants
OR
[Disease name] may be classified into [large number > 6] subtypes based on:
- [Classification method 1]
- [Classification method 2]
- [Classification method 3]
[Disease name] may be classified into several subtypes based on:
- [Classification method 1]
- [Classification method 2]
- [Classification method 3]
OR
Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
OR
If the staging system involves specific and characteristic findings and features:
According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
OR
The staging of [malignancy name] is based on the [staging system].
OR
There is no established system for the staging of [malignancy name].
Migration patterns
Common variants
- Hb S
- Hb C
- Hb E
- Hb D-Punjab
- Hb O-Arab
- Hb G-Philadelphia
- Hb Hasharon
- Hb Korle-Bu
- Hb Lepore
- Hb M
Hemoglobinopathy and evolution
de:Hämoglobinopathie nl:Hemoglobinopathie
- ↑ Kohne E (August 2011). "Hemoglobinopathies: clinical manifestations, diagnosis, and treatment". Dtsch Arztebl Int. 108 (31–32): 532–40. doi:10.3238/arztebl.2011.0532. PMC 3163784. PMID 21886666.