Wilms' tumor laboratory findings: Difference between revisions
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**Serum creatinine | **Serum creatinine | ||
***Done before and after surgical intervention. | ***Done before and after surgical intervention. | ||
** | **Serum calcium | ||
***May be elevated in children suffering from rhabdoid tumor of kidney. | |||
***May be elevated in children suffering from congenital mesoblastic nephroma. | |||
**Elevated serum calcium can be seen in children with rhabdoid tumor of the kidney or congenital mesoblastic nephroma | |||
* | * |
Revision as of 14:34, 5 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal for patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
- The following lab studies are conducted in patients suspected with wilms tumor:
- Complete blood count (CBC)
- Coagulation studies
- Von Willebrand assay
- Done in children with history of hypervascular disease or bleeding.
- Acquired von Willebrand's disease can be present in patients suffering from wilms tumor.[1]
- This is done as a precaution to risk of bleeding that can occur in case of interventions done for wilms tumor.
- Von Willebrand assay
- Liver function test
- Abnormal in case of liver metastasis of wilms tumor.
- Serum creatinine
- Done before and after surgical intervention.
- Serum calcium
- May be elevated in children suffering from rhabdoid tumor of kidney.
- May be elevated in children suffering from congenital mesoblastic nephroma.
- Elevated serum calcium can be seen in children with rhabdoid tumor of the kidney or congenital mesoblastic nephroma
- Laboratory studies include tests for renal function including urinalysis, liver function, serum calcium, a complete blood count, and coagulation studies. ●Serum creatinine is obtained to detect any reduction in glomerular filtration rate prior to surgical intervention. A urinalysis is sent to detect proteinuria, a finding that can occur in patients with Denys-Drash syndrome and mesangial sclerosis. (See 'Denys-Drash syndrome'above.) ●Liver function tests may be abnormal with liver metastases. ●Elevated serum calcium can be seen in children with rhabdoid tumor of the kidney or congenital mesoblastic nephroma [60]. (See 'Differential diagnosis' below.) ●
References
- ↑ Coppes MJ, Zandvoort SW, Sparling CR, Poon AO, Weitzman S, Blanchette VS (March 1992). "Acquired von Willebrand disease in Wilms' tumor patients". J. Clin. Oncol. 10 (3): 422–7. doi:10.1200/JCO.1992.10.3.422. PMID 1311024.