Fanconi syndrome causes: Difference between revisions

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** ''Accumulation of a toxic substance''  (e.g. Cystinosis, Tyrozinemia, Lysinuric Protein Intolerance, Glycogen Storage Diseases, Galactosemia, wilson, fructose intolerance)
** ''Accumulation of a toxic substance''  (e.g. Cystinosis, Tyrozinemia, Lysinuric Protein Intolerance, Glycogen Storage Diseases, Galactosemia, wilson, fructose intolerance)
** ''Energy provision failure'' (e.g. Mitochondriopathies)   
** ''Energy provision failure'' (e.g. Mitochondriopathies)   
** ''Disruption of endocytosis and intra-cellular transport'' (e.g. ARC syndrome, Lowe syndrome and Dent disease).
** ''Disruption of endocytosis and intra-cellular transport mechanisms'' (e.g. ARC syndrome, Lowe syndrome and Dent disease).
* '''Environmental causes''' (e.g. Heavy metals exposure, Drugs, Chemotherapy)
* '''Exogenous causes''' (e.g. Heavy metals exposure, Drugs, Chemotherapy)
* '''Acquired causes''' (e.g. Multiple myeloma, Amyloidosis, Paroxysmal nocturnal hemoglobinuria)
* '''Acquired causes''' (e.g. Multiple myeloma, Amyloidosis, Paroxysmal nocturnal hemoglobinuria)


Line 20: Line 20:
** Tyrozinemia  
** Tyrozinemia  
** Lysinuric Protein Intolerance  
** Lysinuric Protein Intolerance  
** Glycogen Storage Diseases
** Glycogen Storage Disease type I
** Galactosemia
** Galactosemia
** Wilson
** Wilson
** Fructose intolerance
** Fructose intolerance
** Fanconi-Bickel syndrome
* '''Energy provision failure'''
** Mitochondriopathies
* '''Disruption of endocytosis and intra-cellular transport'''
** Lowe syndrome 
** NaPi-IIa gene mutation
** EHHADH gene mutations
** Dent disease


=== '''Environmental causes''' ===
=== '''Exogenous causes''' ===
* Nephrotic syndrome
* Multiple myeloma
* Sjögren syndrome
* Renal transplantation
* Acute tubulointerstitial nephritis with uveitis (TINU) syndrome
* Autoimmune interstitial nephritis and membranous nephropathy
* Anorexia nervosa
* Untreated condition of distal renal tubular acidosis
 
=== '''Acquired causes''' ===
* '''Drugs'''
* '''Drugs'''
** Anti-retroviral drugs
** Anti viral & Anti-retroviral drugs
*** ''Adefovir''
*** ''Adefovir''
*** ''Tenofovir''
*** ''Tenofovir''
*** ''Didanosine''
*** ''Didanosine''
*** ''Cidofovir''
*** ''Cidofovir''
*** ''Lamivudine''
*** ''Stavudine''


** Antibacterial Drugs
** Antibacterial Drugs
Line 49: Line 49:
** Anticonvulsants
** Anticonvulsants
*** ''Valproic acid''
*** ''Valproic acid''
* '''Heavy metals'''
* '''Heavy metals'''
** ''Lead''
** ''Lead''
** ''cadmium''
** ''cadmium''
** ''Mercury''
** ''Mercury''
** ''Copper''
* '''Chemotherapy'''
* '''Chemotherapy'''


** ''Alkylating and Platinating Agents''
** ''Alkylating & Platinating Agents''
*** ''Cisplatin''
*** ''Cisplatin''
*** ''Streptozocin''  
*** ''Streptozocin''  
*** ''Carboplatin''
*** ''Carboplatin''
*** ''Ifosfamide''
*** ''Ifosfamide''
*** ''Oxaplatin''
** ''Mercaptopurine''


** ''Mercaptopurine''.
=== '''Acquired causes''' ===
* ''Nephrotic syndrome''
* ''Multiple myeloma''
* Amyloidosis
* Paroxysmal nocturnal hemoglobinuria(PNH)
* ''Sjögren syndrome''
* ''Renal transplantation''
* ''Acute tubulointerstitial nephritis with uveitis (TINU) syndrome''
* ''Autoimmune interstitial nephritis and membranous nephropathy''
* ''Anorexia nervosa''
* ''Untreated condition of distal renal tubular acidosis''


===Less Common Causes===
===Less Common Causes===
Less common causes of [[disease name]] include:
Less common causes of Fanconi syndrome mostly found on case reports include:
*[Cause1]
*[Cause2]
*[Cause3]
 
===Genetic Causes===
*[Disease name] is caused by a mutation in the [gene name] gene.
 
===Causes by Organ System===


{| style="width:80%; height:100px" border="1"
*Other drugs such as: Fumaric Acid, Ranitidine, Salicylate, Methyl-3-Chromone in high doses and for long periods
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
*Chronic Alcohol abuse
| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
*Crude Chinese herbal drugs (sometimes called Boui-ougi-tou)
|-
*L-Lysine
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
*Glue Sniffing
| bgcolor="Beige" | No underlying causes
*Autosomal dominant Fanconi syndrome with macrosomia and young onset diabetes mellitus
|-
*Arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome
|- bgcolor="LightSteelBlue"
*Idiopathic Fanconi syndrome
| '''Dental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| bgcolor="Beige" | No underlying causes
|-
|}


===Causes in Alphabetical Order===
===Causes in Alphabetical Order===
List the causes of the disease in alphabetical order.
List the causes of the disease in alphabetical order.
{{columns-list|3|
{{columns-list|3|
* Cause 1
*Adefovir
* Cause 2
*Aminoglycosides
* Cause 3
*Cidofovir
* Cause 4
*Cisplatin
* Cause 5
*Cystinosis
* Cause 6
*Dent disease
* Cause 7
*Didanosine
* Cause 8
*Drug-induced
* Cause 9
*Fanconi-Bickel syndrome
* Cause 10
*Galactosemia
*Glycogen Storage disease (type I)
*Hereditary fructose intolerance
*Ifosfamide
*Lamivudine
*Lowe’s syndrome
*Mitochondriopathies
*Oxaplatin
*Stavudine
*Streptozocin
*Tenofovir
*Tyrosinemia
*Valproic acid
*Wilson’s disease
*Tetracyclines
}}
}}


Revision as of 08:17, 5 June 2018


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Fanconi syndrome could be the result or complication of various causes affecting the normal function of Proximal convoluted tubule (PCT) ; in a simple and useful classification method, the causes could be classified as:

  • Genetic causes
    • Accumulation of a toxic substance (e.g. Cystinosis, Tyrozinemia, Lysinuric Protein Intolerance, Glycogen Storage Diseases, Galactosemia, wilson, fructose intolerance)
    • Energy provision failure (e.g. Mitochondriopathies)
    • Disruption of endocytosis and intra-cellular transport mechanisms (e.g. ARC syndrome, Lowe syndrome and Dent disease).
  • Exogenous causes (e.g. Heavy metals exposure, Drugs, Chemotherapy)
  • Acquired causes (e.g. Multiple myeloma, Amyloidosis, Paroxysmal nocturnal hemoglobinuria)

Causes

Genetic Causes

  • Accumulation of a toxic substance
    • Cystinosis
      • The most common inherited cause of Fanconi syndrome in children
    • Tyrozinemia
    • Lysinuric Protein Intolerance
    • Glycogen Storage Disease type I
    • Galactosemia
    • Wilson
    • Fructose intolerance
    • Fanconi-Bickel syndrome
  • Energy provision failure
    • Mitochondriopathies
  • Disruption of endocytosis and intra-cellular transport
    • Lowe syndrome
    • NaPi-IIa gene mutation
    • EHHADH gene mutations
    • Dent disease

Exogenous causes

  • Drugs
    • Anti viral & Anti-retroviral drugs
      • Adefovir
      • Tenofovir
      • Didanosine
      • Cidofovir
      • Lamivudine
      • Stavudine
    • Antibacterial Drugs
      • Tetracyclines
      • Aminoglycosides
    • Anticonvulsants
      • Valproic acid
  • Heavy metals
    • Lead
    • cadmium
    • Mercury
    • Copper
  • Chemotherapy
    • Alkylating & Platinating Agents
      • Cisplatin
      • Streptozocin
      • Carboplatin
      • Ifosfamide
      • Oxaplatin
    • Mercaptopurine

Acquired causes

  • Nephrotic syndrome
  • Multiple myeloma
  • Amyloidosis
  • Paroxysmal nocturnal hemoglobinuria(PNH)
  • Sjögren syndrome
  • Renal transplantation
  • Acute tubulointerstitial nephritis with uveitis (TINU) syndrome
  • Autoimmune interstitial nephritis and membranous nephropathy
  • Anorexia nervosa
  • Untreated condition of distal renal tubular acidosis

Less Common Causes

Less common causes of Fanconi syndrome mostly found on case reports include:

  • Other drugs such as: Fumaric Acid, Ranitidine, Salicylate, Methyl-3-Chromone in high doses and for long periods
  • Chronic Alcohol abuse
  • Crude Chinese herbal drugs (sometimes called Boui-ougi-tou)
  • L-Lysine
  • Glue Sniffing
  • Autosomal dominant Fanconi syndrome with macrosomia and young onset diabetes mellitus
  • Arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome
  • Idiopathic Fanconi syndrome

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.
3

References

Template:WH Template:WS

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