Tabes Dorsalis pathophysiology: Difference between revisions
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== Overview == | == Overview == | ||
It is understood that tabes dorsalis is caused by [[tertiary syphilis]] from [[treponema pallidum]] infection. | |||
Tabes dorsalis is a manifestation of invasion of [[treponema pallidum]] [[Spirochaete|spirochete]]<nowiki/>s to the [[Dorsal column|dorsal column of spinal cord]] in [[tertiary syphilis]]. | |||
In tabes dorsalis, the preganglionic portion of the dorsal roots of spinal nerves is infiltrated with [[Lymphocyte|lymphocytes]] and [[plasma cells]], and invasion of [[treponema pallidum]] [[Spirochaete|spirochete]]<nowiki/>s to [[Posterior column|posterior columns]] of the [[spinal cord]] makes it [[Atrophy|atrophic]]. | |||
The [[demyelination]] of the [[Axoneme|axones]] of the [[neurons]] is the main cause of symptoms and it affects the [[neurons]] in the [[Dorsal root ganglion|dorsal root ganglia]] and [[Posterior columns|posterior columns of the spinal cord]]. | |||
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== Pathophysiology == | == Pathophysiology == | ||
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=== Pathogenesis === | === Pathogenesis === | ||
* It is understood that tabes dorsalis is caused by [[tertiary syphilis]] from [[treponema pallidum]] infection.<ref name="pmid17235095">{{cite journal| author=French P| title=Syphilis. | journal=BMJ | year= 2007 | volume= 334 | issue= 7585 | pages= 143-7 | pmid=17235095 | doi=10.1136/bmj.39085.518148.BE | pmc=1779891 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17235095 }} </ref> | * It is understood that tabes dorsalis is caused by [[tertiary syphilis]] from [[treponema pallidum]] infection.<ref name="pmid17235095">{{cite journal| author=French P| title=Syphilis. | journal=BMJ | year= 2007 | volume= 334 | issue= 7585 | pages= 143-7 | pmid=17235095 | doi=10.1136/bmj.39085.518148.BE | pmc=1779891 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17235095 }} </ref> | ||
* Tabes dorsalis is a manifestation of invasion of [[treponema pallidum]] [[Spirochaete|spirochete]]<nowiki/>s to the dorsal column of spinal cord in [[tertiary syphilis]].<ref name="pmid10194456">{{cite journal| author=Singh AE, Romanowski B| title=Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features. | journal=Clin Microbiol Rev | year= 1999 | volume= 12 | issue= 2 | pages= 187-209 | pmid=10194456 | doi= | pmc=88914 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10194456 }} </ref> | * Tabes dorsalis is a manifestation of invasion of [[treponema pallidum]] [[Spirochaete|spirochete]]<nowiki/>s to the [[Dorsal column|dorsal column of spinal cord]] in [[tertiary syphilis]].<ref name="pmid10194456">{{cite journal| author=Singh AE, Romanowski B| title=Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features. | journal=Clin Microbiol Rev | year= 1999 | volume= 12 | issue= 2 | pages= 187-209 | pmid=10194456 | doi= | pmc=88914 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10194456 }} </ref> | ||
* In tabes dorsalis, the preganglionic portion of the dorsal roots of spinal nerves is infiltrated with [[Lymphocyte|lymphocytes]] and [[plasma cells]], and invasion of [[treponema pallidum]] [[Spirochaete|spirochete]]<nowiki/>s to [[Posterior column|posterior columns]] of the [[spinal cord]] makes it [[Atrophy|atrophic]].<ref name="pmid21694502">{{cite journal| author=Carlson JA, Dabiri G, Cribier B, Sell S| title=The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity. | journal=Am J Dermatopathol | year= 2011 | volume= 33 | issue= 5 | pages= 433-60 | pmid=21694502 | doi=10.1097/DAD.0b013e3181e8b587 | pmc=3690623 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21694502 }} </ref> | |||
* In tabes dorsalis, the preganglionic portion of the dorsal roots of spinal nerves is infiltrated with lymphocytes and plasma cells, and invasion of [[treponema pallidum]] [[Spirochaete|spirochete]]<nowiki/>s to posterior columns of the spinal cord makes it atrophic.<ref name="pmid21694502">{{cite journal| author=Carlson JA, Dabiri G, Cribier B, Sell S| title=The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity. | journal=Am J Dermatopathol | year= 2011 | volume= 33 | issue= 5 | pages= 433-60 | pmid=21694502 | doi=10.1097/DAD.0b013e3181e8b587 | pmc=3690623 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21694502 }} </ref> | * The [[demyelination]] of the [[Axoneme|axones]] of the [[neurons]] is the main cause of symptoms and it affects the [[neurons]] in the [[Dorsal root ganglion|dorsal root ganglia]] and [[Posterior columns|posterior columns of the spinal cord]].<nowiki/><ref name="pmid21694502">{{cite journal| author=Carlson JA, Dabiri G, Cribier B, Sell S| title=The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity. | journal=Am J Dermatopathol | year= 2011 | volume= 33 | issue= 5 | pages= 433-60 | pmid=21694502 | doi=10.1097/DAD.0b013e3181e8b587 | pmc=3690623 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21694502 }} </ref> | ||
* The demyelination of the axones of the neurons is the main cause of symptoms and it affects the neurons in the dorsal root ganglia and posterior columns of the spinal cord.<nowiki/> | |||
== Genetics == | == Genetics == | ||
* There is no stablished relation between tabes dorsalis and genetic factors. | * There is no stablished relation between tabes dorsalis and genetic factors. | ||
== References == | == References == | ||
Revision as of 17:26, 8 February 2018
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
It is understood that tabes dorsalis is caused by tertiary syphilis from treponema pallidum infection.
Tabes dorsalis is a manifestation of invasion of treponema pallidum spirochetes to the dorsal column of spinal cord in tertiary syphilis.
In tabes dorsalis, the preganglionic portion of the dorsal roots of spinal nerves is infiltrated with lymphocytes and plasma cells, and invasion of treponema pallidum spirochetes to posterior columns of the spinal cord makes it atrophic.
The demyelination of the axones of the neurons is the main cause of symptoms and it affects the neurons in the dorsal root ganglia and posterior columns of the spinal cord.
Pathophysiology
Pathogenesis
- It is understood that tabes dorsalis is caused by tertiary syphilis from treponema pallidum infection.[1]
- Tabes dorsalis is a manifestation of invasion of treponema pallidum spirochetes to the dorsal column of spinal cord in tertiary syphilis.[2]
- In tabes dorsalis, the preganglionic portion of the dorsal roots of spinal nerves is infiltrated with lymphocytes and plasma cells, and invasion of treponema pallidum spirochetes to posterior columns of the spinal cord makes it atrophic.[3]
- The demyelination of the axones of the neurons is the main cause of symptoms and it affects the neurons in the dorsal root ganglia and posterior columns of the spinal cord.[3]
Genetics
- There is no stablished relation between tabes dorsalis and genetic factors.
References
- ↑ French P (2007). "Syphilis". BMJ. 334 (7585): 143–7. doi:10.1136/bmj.39085.518148.BE. PMC 1779891. PMID 17235095.
- ↑ Singh AE, Romanowski B (1999). "Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features". Clin Microbiol Rev. 12 (2): 187–209. PMC 88914. PMID 10194456.
- ↑ 3.0 3.1 Carlson JA, Dabiri G, Cribier B, Sell S (2011). "The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity". Am J Dermatopathol. 33 (5): 433–60. doi:10.1097/DAD.0b013e3181e8b587. PMC 3690623. PMID 21694502.