EIF1AX: Difference between revisions

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== Function ==
== Function ==
eIF1A is a small proteins (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal [[A-site]], in a manner similar to the functionally related bacterial counterpart [[Prokaryotic initiation factor-3|IF1]].<ref name="Fraser">{{cite journal|last1=Fraser|first1=Christopher S.|title=Quantitative studies of mRNA recruitment to the eukaryotic ribosome|journal=Biochimie|date=2015|volume=114|pages=58–71|doi=10.1016/j.biochi.2015.02.017|pmid=25742741|url=http://www.sciencedirect.com/science/article/pii/S0300908415000528|accessdate=6 March 2016|pmc=4458453}}</ref>
eIF1A is a small protein (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal [[A-site]], in a manner similar to the functionally related bacterial counterpart [[Prokaryotic initiation factor-3|IF1]].<ref name="Fraser">{{cite journal|last1=Fraser|first1=Christopher S.|title=Quantitative studies of mRNA recruitment to the eukaryotic ribosome|journal=Biochimie|date=2015|volume=114|pages=58–71|doi=10.1016/j.biochi.2015.02.017|pmid=25742741|url=http://www.sciencedirect.com/science/article/pii/S0300908415000528|accessdate=6 March 2016|pmc=4458453}}</ref>


== Clinical significance ==
== Clinical significance ==
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* {{cite journal | vauthors = Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Görlich D | title = Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm | journal = The EMBO Journal | volume = 21 | issue = 22 | pages = 6205–15 | date = Nov 2002 | pmid = 12426392 | pmc = 137205 | doi = 10.1093/emboj/cdf613 }}
* {{cite journal | vauthors = Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Görlich D | title = Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm | journal = The EMBO Journal | volume = 21 | issue = 22 | pages = 6205–15 | date = Nov 2002 | pmid = 12426392 | pmc = 137205 | doi = 10.1093/emboj/cdf613 }}
* {{cite journal | vauthors = Olsen DS, Savner EM, Mathew A, Zhang F, Krishnamoorthy T, Phan L, Hinnebusch AG | title = Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo | journal = The EMBO Journal | volume = 22 | issue = 2 | pages = 193–204 | date = Jan 2003 | pmid = 12514125 | pmc = 140105 | doi = 10.1093/emboj/cdg030 }}
* {{cite journal | vauthors = Olsen DS, Savner EM, Mathew A, Zhang F, Krishnamoorthy T, Phan L, Hinnebusch AG | title = Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo | journal = The EMBO Journal | volume = 22 | issue = 2 | pages = 193–204 | date = Jan 2003 | pmid = 12514125 | pmc = 140105 | doi = 10.1093/emboj/cdg030 }}
* {{cite journal | vauthors = Marintchev A, Kolupaeva VG, Pestova TV, Wagner G | title = Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 4 | pages = 1535–40 | date = Feb 2003 | pmid = 12569173 | pmc = 149867 | doi = 10.1073/pnas.0437845100 }}
* {{cite journal | vauthors = Marintchev A, Kolupaeva VG, Pestova TV, Wagner G | title = Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 4 | pages = 1535–40 | date = Feb 2003 | pmid = 12569173 | pmc = 149867 | doi = 10.1073/pnas.0437845100 | bibcode = 2003PNAS..100.1535M }}
* {{cite journal | vauthors = Agate RJ, Choe M, Arnold AP | title = Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches | journal = Molecular Biology and Evolution | volume = 21 | issue = 2 | pages = 384–96 | date = Feb 2004 | pmid = 14660691 | doi = 10.1093/molbev/msh027 }}
* {{cite journal | vauthors = Agate RJ, Choe M, Arnold AP | title = Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches | journal = Molecular Biology and Evolution | volume = 21 | issue = 2 | pages = 384–96 | date = Feb 2004 | pmid = 14660691 | doi = 10.1093/molbev/msh027 }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R }}
* {{cite journal | vauthors = Kim S, Kim GJ, Miyoshi H, Moon SH, Ahn SE, Lee JH, Lee HJ, Cha KY, Chung HM | title = Efficiency of the elongation factor-1alpha promoter in mammalian embryonic stem cells using lentiviral gene delivery systems | journal = Stem Cells and Development | volume = 16 | issue = 4 | pages = 537–45 | date = Aug 2007 | pmid = 17784828 | doi = 10.1089/scd.2006.0088 }}
* {{cite journal | vauthors = Kim S, Kim GJ, Miyoshi H, Moon SH, Ahn SE, Lee JH, Lee HJ, Cha KY, Chung HM | title = Efficiency of the elongation factor-1alpha promoter in mammalian embryonic stem cells using lentiviral gene delivery systems | journal = Stem Cells and Development | volume = 16 | issue = 4 | pages = 537–45 | date = Aug 2007 | pmid = 17784828 | doi = 10.1089/scd.2006.0088 }}
{{refend}}
{{refend}}

Latest revision as of 10:14, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene.[1][2][3] This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.[3]

Function

eIF1A is a small protein (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal A-site, in a manner similar to the functionally related bacterial counterpart IF1.[4]

Clinical significance

Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3.[5]

Interactions

EIF1AX has been shown to interact with IPO13.[6]

See also

References

  1. ↑ Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW (Feb 1994). "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing". The Journal of Biological Chemistry. 269 (5): 3212–8. PMID 8106356.
  2. ↑ Lahn BT, Page DC (Oct 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
  3. ↑ 3.0 3.1 "Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked".
  4. ↑ Fraser, Christopher S. (2015). "Quantitative studies of mRNA recruitment to the eukaryotic ribosome". Biochimie. 114: 58–71. doi:10.1016/j.biochi.2015.02.017. PMC 4458453. PMID 25742741. Retrieved 6 March 2016.
  5. ↑ Martin M, Maßhöfer L, Temming P, Rahmann S, Metz C, Bornfeld N, van de Nes J, Klein-Hitpass L, Hinnebusch AG, Horsthemke B, Lohmann DR, Zeschnigk M (Aug 2013). "Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3". Nature Genetics. 45 (8): 933–6. doi:10.1038/ng.2674. PMC 4307600. PMID 23793026.
  6. ↑ Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D (Jul 2001). "Importin 13: a novel mediator of nuclear import and export". The EMBO Journal. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. PMC 125545. PMID 11447110.

Further reading


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