VWA2: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}


'''von Willebrand factor A domain-containing protein 2''', also known as '''A domain-containing protein similar to matrilin and collagen''' (AMACO) is a [[protein]] that in humans is encoded by the ''VWA2'' [[gene]].<ref name="entrez_340706">{{cite web | title = Entrez Gene: von Willebrand factor A domain containing 2  | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=340706| accessdate = }}</ref><ref name="pmid14506275">{{cite journal | vauthors = Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R | title = Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney | journal = J. Biol. Chem. | volume = 278 | issue = 50 | pages = 50240–9 |date=December 2003 | pmid = 14506275 | doi = 10.1074/jbc.M307794200 | url = | issn = }}</ref>
'''von Willebrand factor A domain-containing protein 2''', also known as '''A domain-containing protein similar to matrilin and collagen''' (AMACO) is a [[protein]] that in humans is encoded by the ''VWA2'' [[gene]].<ref name="entrez_340706">{{cite web | title = Entrez Gene: von Willebrand factor A domain containing 2  | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=340706| access-date = }}</ref><ref name="pmid14506275">{{cite journal | vauthors = Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R | title = Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 50240–9 | date = December 2003 | pmid = 14506275 | doi = 10.1074/jbc.M307794200 }}</ref>


AMACO is a member of the [[Von Willebrand factor type A domain|von Willebrand factor A]]-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two [[EGF-like domain]]s, a cysteine-rich domain and a unique C-terminal domain.<ref name="pmid14506275"/>
AMACO is a member of the [[Von Willebrand factor type A domain|von Willebrand factor A]]-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two [[EGF-like domain]]s, a cysteine-rich domain and a unique C-terminal domain.<ref name="pmid14506275"/>
AMACO is an [[extracellular matrix]] protein and mostly deposited adjacent to [[basement membrane]]s.<ref name="pmid19651211">{{cite journal | vauthors = Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R | title = Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment | journal = Matrix Biol. | volume = 28| issue = 8| pages = 456–62|date=August 2009 | pmid = 19651211 | doi = 10.1016/j.matbio.2009.07.006 | url = | issn = }}</ref>
AMACO is an [[extracellular matrix]] protein and mostly deposited adjacent to [[basement membrane]]s.<ref name="pmid19651211">{{cite journal | vauthors = Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R | title = Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment | journal = Matrix Biology | volume = 28 | issue = 8 | pages = 456–62 | date = October 2009 | pmid = 19651211 | doi = 10.1016/j.matbio.2009.07.006 }}</ref>


The function of this protein is not yet clear; however, it was found markedly induced in [[colon cancer]]s <ref name="pmid15580307">{{cite journal | vauthors = Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Wilson K, Markowitz S | title = Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia | journal = Oncogene | volume = 24 | issue = 4 | pages = 724–31 |date=January 2005 | pmid = 15580307 | doi = 10.1038/sj.onc.1208134 | url = | issn = }}</ref> and may be useful diagnostic serum marker.
AMACO binds directly to [[FRAS1]] which is part of the Fraser complex important for epithelial-connective tissue interaction<ref>{{cite journal | vauthors = Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlsen KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R | title = AMACO is a component of the basement membrane-associated Fraser complex | journal = The Journal of Investigative Dermatology | volume = 134 | issue = 5 | pages = 1313–1322 | date = May 2014 | pmid = 24232570 | pmc = 4361737 | doi = 10.1038/jid.2013.492 }}</ref>, the exact biological role of AMACO, however, is still unknown. In 2005 AMACO was found markedly induced in [[colon cancer]]s <ref name="pmid15580307">{{cite journal | vauthors = Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Wilson K, Markowitz S | title = Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia | journal = Oncogene | volume = 24 | issue = 4 | pages = 724–31 | date = January 2005 | pmid = 15580307 | doi = 10.1038/sj.onc.1208134 }}</ref>; indicating that it might be a good candidate as a biomarker for this type of cancer.


==References==
== References ==
{{Reflist|2}}
{{Reflist|2}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal   |vauthors=Eller E, Vardi P, Daly MJ, etal |title=IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family. |journal=Ann. N. Y. Acad. Sci. |volume=1037 |issue= 1|pages= 145–9 |year= 2004 |pmid= 15699509 |doi= 10.1196/annals.1337.024 }}
* {{cite journal | vauthors = Eller E, Vardi P, Daly MJ, Babu S, Roberts C, Yang F, Eisenbarth GS, Fain PR | title = IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family | journal = Annals of the New York Academy of Sciences | volume = 1037 | issue = 1 | pages = 145–9 | date = December 2004 | pmid = 15699509 | doi = 10.1196/annals.1337.024 }}
*{{cite journal   |vauthors=Gebauer JM, Müller S, Hanisch FG, etal |title=O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein). |journal=J. Biol. Chem. |volume=283 |issue= 26 |pages= 17846–54 |year= 2008 |pmid= 18434322 |doi= 10.1074/jbc.M704820200 }}
* {{cite journal | vauthors = Gebauer JM, Müller S, Hanisch FG, Paulsson M, Wagener R | title = O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein) | journal = The Journal of Biological Chemistry | volume = 283 | issue = 26 | pages = 17846–54 | date = June 2008 | pmid = 18434322 | doi = 10.1074/jbc.M704820200 }}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|VWA2+protein,+human}}
* {{MeshName|VWA2+protein,+human}}


{{gene-10-stub}}
{{gene-10-stub}}


[[Category:Extracellular matrix proteins]]
[[Category:Extracellular matrix proteins]]

Latest revision as of 07:41, 5 November 2018

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Wikidata
View/Edit Human

von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO) is a protein that in humans is encoded by the VWA2 gene.[1][2]

AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain.[2] AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes.[3]

AMACO binds directly to FRAS1 which is part of the Fraser complex important for epithelial-connective tissue interaction[4], the exact biological role of AMACO, however, is still unknown. In 2005 AMACO was found markedly induced in colon cancers [5]; indicating that it might be a good candidate as a biomarker for this type of cancer.

References

  1. ↑ "Entrez Gene: von Willebrand factor A domain containing 2".
  2. ↑ 2.0 2.1 Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R (December 2003). "Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney". The Journal of Biological Chemistry. 278 (50): 50240–9. doi:10.1074/jbc.M307794200. PMID 14506275.
  3. ↑ Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R (October 2009). "Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment". Matrix Biology. 28 (8): 456–62. doi:10.1016/j.matbio.2009.07.006. PMID 19651211.
  4. ↑ Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlsen KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R (May 2014). "AMACO is a component of the basement membrane-associated Fraser complex". The Journal of Investigative Dermatology. 134 (5): 1313–1322. doi:10.1038/jid.2013.492. PMC 4361737. PMID 24232570.
  5. ↑ Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Wilson K, Markowitz S (January 2005). "Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia". Oncogene. 24 (4): 724–31. doi:10.1038/sj.onc.1208134. PMID 15580307.

Further reading

  • Eller E, Vardi P, Daly MJ, Babu S, Roberts C, Yang F, Eisenbarth GS, Fain PR (December 2004). "IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family". Annals of the New York Academy of Sciences. 1037 (1): 145–9. doi:10.1196/annals.1337.024. PMID 15699509.
  • Gebauer JM, Müller S, Hanisch FG, Paulsson M, Wagener R (June 2008). "O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein)". The Journal of Biological Chemistry. 283 (26): 17846–54. doi:10.1074/jbc.M704820200. PMID 18434322.

External links

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