PPP1R2: Difference between revisions
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==Interactions== | ==Interactions== | ||
PPP1R2 has been shown to [[Protein-protein interaction|interact]] with [[LMTK2]]<ref name=pmid12393858>{{cite journal |last=Wang |first=Hong |authorlink= |author2=Brautigan David L |date=Dec 2002 |title=A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2 |journal=J. Biol. Chem. |volume=277 |issue=51 |pages=49605–12 |publisher= |location = United States| issn = 0021-9258| pmid = 12393858 |doi = 10.1074/jbc.M209335200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[PPP1R9B]].<ref name=pmid12270929>{{cite journal |last=Terry-Lorenzo |first=Ryan T |authorlink= |author2=Elliot Elizabeth |author3=Weiser Douglas C |author4=Prickett Todd D |author5=Brautigan David L |author6=Shenolikar Shirish |date=Nov 2002 |title=Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton |journal=J. Biol. Chem. |volume=277 |issue=48 |pages=46535–43 |publisher= |location = United States| issn = 0021-9258| pmid = 12270929 |doi = 10.1074/jbc.M206960200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | PPP1R2 has been shown to [[Protein-protein interaction|interact]] with [[LMTK2]]<ref name=pmid12393858>{{cite journal |last=Wang |first=Hong |authorlink= |author2=Brautigan David L |date=Dec 2002 |title=A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2 |journal=J. Biol. Chem. |volume=277 |issue=51 |pages=49605–12 |publisher= |location = United States| issn = 0021-9258| pmid = 12393858 |doi = 10.1074/jbc.M209335200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[PPP1R9B]].<ref name=pmid12270929>{{cite journal |last=Terry-Lorenzo |first=Ryan T |authorlink= |author2=Elliot Elizabeth |author3=Weiser Douglas C |author4=Prickett Todd D |author5=Brautigan David L |author6=Shenolikar Shirish |date=Nov 2002 |title=Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton |journal=J. Biol. Chem. |volume=277 |issue=48 |pages=46535–43 |publisher= |location = United States| issn = 0021-9258| pmid = 12270929 |doi = 10.1074/jbc.M206960200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | ||
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*{{cite journal |vauthors=Terry-Lorenzo RT, Elliot E, Weiser DC, etal |title=Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46535–43 |year= 2003 |pmid= 12270929 |doi= 10.1074/jbc.M206960200 }} | *{{cite journal |vauthors=Terry-Lorenzo RT, Elliot E, Weiser DC, etal |title=Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46535–43 |year= 2003 |pmid= 12270929 |doi= 10.1074/jbc.M206960200 }} | ||
*{{cite journal |vauthors=Wang H, Brautigan DL |title=A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49605–12 |year= 2003 |pmid= 12393858 |doi= 10.1074/jbc.M209335200 }} | *{{cite journal |vauthors=Wang H, Brautigan DL |title=A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49605–12 |year= 2003 |pmid= 12393858 |doi= 10.1074/jbc.M209335200 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }} | *{{cite journal |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }} | ||
*{{cite journal |vauthors=Leach C, Shenolikar S, Brautigan DL |title=Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 26015–20 |year= 2003 |pmid= 12697755 |doi= 10.1074/jbc.M300782200 }} | *{{cite journal |vauthors=Leach C, Shenolikar S, Brautigan DL |title=Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 26015–20 |year= 2003 |pmid= 12697755 |doi= 10.1074/jbc.M300782200 }} | ||
*{{cite journal |vauthors=Sakashita G, Shima H, Komatsu M, etal |title=Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. |journal=J. Biochem. |volume=133 |issue= 2 |pages= 165–71 |year= 2004 |pmid= 12761178 |doi=10.1093/jb/mvg020 }} | *{{cite journal |vauthors=Sakashita G, Shima H, Komatsu M, etal |title=Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. |journal=J. Biochem. |volume=133 |issue= 2 |pages= 165–71 |year= 2004 |pmid= 12761178 |doi=10.1093/jb/mvg020 }} | ||
*{{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }} | *{{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }} | ||
*{{cite journal |vauthors=Yamada M, Ikeda Y, Yano M, etal |title=Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy. |journal=FASEB J. |volume=20 |issue= 8 |pages= 1197–9 |year= 2006 |pmid= 16627625 |doi= 10.1096/fj.05-5299fje }} | *{{cite journal |vauthors=Yamada M, Ikeda Y, Yano M, etal |title=Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy. |journal=FASEB J. |volume=20 |issue= 8 |pages= 1197–9 |year= 2006 |pmid= 16627625 |doi= 10.1096/fj.05-5299fje }} | ||
*{{cite journal |vauthors=King TD, Gandy JC, Bijur GN |title=The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels. |journal=Exp. Cell Res. |volume=312 |issue= 18 |pages= 3693–700 |year= 2007 |pmid= 16987514 |doi= 10.1016/j.yexcr.2006.08.010 | pmc=1885546 }} | *{{cite journal |vauthors=King TD, Gandy JC, Bijur GN |title=The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels. |journal=Exp. Cell Res. |volume=312 |issue= 18 |pages= 3693–700 |year= 2007 |pmid= 16987514 |doi= 10.1016/j.yexcr.2006.08.010 | pmc=1885546 }} | ||
Latest revision as of 19:49, 25 June 2018
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Protein phosphatase inhibitor 2 is an enzyme that in humans is encoded by the PPP1R2 gene.[1][2][3]
Interactions
PPP1R2 has been shown to interact with LMTK2[4] and PPP1R9B.[5]
References
- ↑ Permana PA, Mott DM (May 1997). "Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians". Genomics. 41 (1): 110–4. doi:10.1006/geno.1997.4649. PMID 9126490.
- ↑ Helps NR, Street AJ, Elledge SJ, Cohen PT (Apr 1994). "Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli". FEBS Lett. 340 (1–2): 93–8. doi:10.1016/0014-5793(94)80179-7. PMID 8119416.
- ↑ "Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2".
- ↑ Wang, Hong; Brautigan David L (Dec 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. Biol. Chem. United States. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. ISSN 0021-9258. PMID 12393858.
- ↑ Terry-Lorenzo, Ryan T; Elliot Elizabeth; Weiser Douglas C; Prickett Todd D; Brautigan David L; Shenolikar Shirish (Nov 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. United States. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. ISSN 0021-9258. PMID 12270929.
Further reading
- Sanséau P, Jackson A, Alderton RP, et al. (1994). "Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences". Mamm. Genome. 5 (8): 490–6. doi:10.1007/BF00369318. PMID 7949733.
- Park IK, Roach P, Bondor J, et al. (1994). "Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2". J. Biol. Chem. 269 (2): 944–54. PMID 8288648.
- Kakinoki Y, Somers J, Brautigan DL (1998). "Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle". J. Biol. Chem. 272 (51): 32308–14. doi:10.1074/jbc.272.51.32308. PMID 9405437.
- Yang J, Hurley TD, DePaoli-Roach AA (2000). "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif". J. Biol. Chem. 275 (30): 22635–44. doi:10.1074/jbc.M003082200. PMID 10807923.
- Agarwal-Mawal A, Paudel HK (2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2". J. Biol. Chem. 276 (26): 23712–8. doi:10.1074/jbc.M010002200. PMID 11320080.
- Eto M, Elliott E, Prickett TD, Brautigan DL (2003). "Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation". J. Biol. Chem. 277 (46): 44013–20. doi:10.1074/jbc.M208035200. PMID 12221103.
- Terry-Lorenzo RT, Elliot E, Weiser DC, et al. (2003). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. PMID 12270929.
- Wang H, Brautigan DL (2003). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. Biol. Chem. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. PMID 12393858.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Leach C, Shenolikar S, Brautigan DL (2003). "Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis". J. Biol. Chem. 278 (28): 26015–20. doi:10.1074/jbc.M300782200. PMID 12697755.
- Sakashita G, Shima H, Komatsu M, et al. (2004). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". J. Biochem. 133 (2): 165–71. doi:10.1093/jb/mvg020. PMID 12761178.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- Yamada M, Ikeda Y, Yano M, et al. (2006). "Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy". FASEB J. 20 (8): 1197–9. doi:10.1096/fj.05-5299fje. PMID 16627625.
- King TD, Gandy JC, Bijur GN (2007). "The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels". Exp. Cell Res. 312 (18): 3693–700. doi:10.1016/j.yexcr.2006.08.010. PMC 1885546. PMID 16987514.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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