Giant cell tumor of bone overview: Difference between revisions
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Giant cell tumor of the bone accounts for 4-5% of primary bone tumors and 18.2% of benign bone tumors <ref name="pmid12579271">{{cite journal |author=Gamberi G, Serra M, Ragazzini P, Magagnoli G, Pazzaglia L, Ponticelli F, Ferrari C, Zanasi M, Bertoni F, Picci P, Benassi MS |title=Identification of markers of possible prognostic value in 57 giant cell tumors of bone |journal=[[Oncology Reports]] |volume=10 |issue=2 |pages=351–6 |year=2003 |pmid=12579271 |doi= |url=http://www.spandidos-publications.com/or/10/2/351 |accessdate=2012-01-18}}</ref>. Giant cell tumors are mostly benign, however 5-10% of patients may have a malignant tumor. | Giant cell tumor of the bone accounts for 4-5% of primary bone tumors and 18.2% of benign bone tumors <ref name="pmid12579271">{{cite journal |author=Gamberi G, Serra M, Ragazzini P, Magagnoli G, Pazzaglia L, Ponticelli F, Ferrari C, Zanasi M, Bertoni F, Picci P, Benassi MS |title=Identification of markers of possible prognostic value in 57 giant cell tumors of bone |journal=[[Oncology Reports]] |volume=10 |issue=2 |pages=351–6 |year=2003 |pmid=12579271 |doi= |url=http://www.spandidos-publications.com/or/10/2/351 |accessdate=2012-01-18}}</ref>. Giant cell tumors are mostly benign, however 5-10% of patients may have a malignant tumor. | ||
===Differential Diagnosis=== | |||
A number of tumors have giant cells, but are not true benign giant cell tumors. These include | |||
* [[Aneurysmal bone cyst]] | |||
* [[Chondroblastoma]] | |||
* Simple bone cyst | |||
* Osteoid osteoma | |||
* [[Osteoblastoma]] | |||
* [[Osteosarcoma]] | |||
* Giant cell reparative granuloma | |||
* [[Brown tumor]] of hyperparathyroidism. | |||
Revision as of 15:35, 9 March 2016
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Differentiating Giant cell tumor of bone from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Giant cell tumor of the bone is a relatively uncommon tumor. It is characterized by the presence of multinucleated giant cells (osteoclast-like cells). These tumors are generally benign. In most patients, the tumors are slow to develop, but may recur locally in as many as 50% of cases. Metastasis to the lungs may occur.
Prevalence
Giant cell tumor of the bone accounts for 4-5% of primary bone tumors and 18.2% of benign bone tumors [1]. Giant cell tumors are mostly benign, however 5-10% of patients may have a malignant tumor.
Differential Diagnosis
A number of tumors have giant cells, but are not true benign giant cell tumors. These include
- Aneurysmal bone cyst
- Chondroblastoma
- Simple bone cyst
- Osteoid osteoma
- Osteoblastoma
- Osteosarcoma
- Giant cell reparative granuloma
- Brown tumor of hyperparathyroidism.
References
- ↑ Gamberi G, Serra M, Ragazzini P, Magagnoli G, Pazzaglia L, Ponticelli F, Ferrari C, Zanasi M, Bertoni F, Picci P, Benassi MS (2003). "Identification of markers of possible prognostic value in 57 giant cell tumors of bone". Oncology Reports. 10 (2): 351–6. PMID 12579271. Retrieved 2012-01-18.