Donovanosis pathophysiology: Difference between revisions

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===Transmission===
===Transmission===
*''Klebsiella granulomatis'' may be transmitted through sexual contact.
*''Klebsiella granulomatis'' may be transmitted through sexual contact.
*Although donovanosisis is typically considered a [[sexually transmitted disease]], studies indicate it may also develop through fecal contamination or dermal contact.
*Although donovanosisis is typically considered a [[sexually transmitted disease]], studies indicate it may also develop through fecal [[contamination]] or dermal contact.
*''K. granulomatis'' may also autoinoculate, resulting in multiple lesions that appear to be mirror images of each other.<ref name=" O'Farrell">{{cite journal| author=O'Farrell N| title=Donovanosis. | journal=Sex Transm Infect | year= 2002 | volume= 78 | issue= 6 | pages= 452-7 | pmid=12473810 | doi= | pmc=PMC1758360 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12473810  }} </ref>
*''K. granulomatis'' may also [[Autoinoculation|autoinoculate]], resulting in multiple lesions that appear to be mirror images of each other.<ref name="O'Farrell">{{cite journal| author=O'Farrell N| title=Donovanosis. | journal=Sex Transm Infect | year= 2002 | volume= 78 | issue= 6 | pages= 452-7 | pmid=12473810 | doi= | pmc=PMC1758360 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12473810  }} </ref>


===Pathogenesis===
===Pathogenesis===
Line 20: Line 20:


==Microscopic Pathology==
==Microscopic Pathology==
*Donovan bodies (''K. granulomatis'') are seen within phagosomes or in the cytoplasm of monocytes or histocytes.
*Donovan bodies (''K. granulomatis'') are seen within [[Phagosome|phagosomes]] or in the cytoplasm of [[Monocyte|monocytes]] or [[Histiocyte|histocytes]].
*Morphology of Donovan bodies:
*Morphology of Donovan bodies:
:*Pleomorphic ranging from coccus to bacillus
:*[[Pleomorphic]] ranging from [[coccus]] to [[bacillus]]
:*1-2 X 0.5-0.7 μm
:*1-2 X 0.5-0.7 μm
:*May or may not be capsulated
:*May or may not be capsulated
:*Non-motile
:*Non-motile
*[[Epidermis]] of lesion borders show a degree of [[hyperplasia]].
*[[Epidermis]] of lesion borders show a degree of [[hyperplasia]].
*A dense infiltrate of plasma cells is seen in the [[dermis]].<ref name="Richens">{{cite journal| author=Richens J| title=The diagnosis and treatment of donovanosis (granuloma inguinale). | journal=Genitourin Med | year= 1991 | volume= 67 | issue= 6 | pages= 441-52 | pmid=1774048 | doi= | pmc=PMC1194766 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1774048  }} </ref>
*A dense infiltrate of [[Plasma cell|plasma cells]] is seen in the [[dermis]].<ref name="Richens">{{cite journal| author=Richens J| title=The diagnosis and treatment of donovanosis (granuloma inguinale). | journal=Genitourin Med | year= 1991 | volume= 67 | issue= 6 | pages= 441-52 | pmid=1774048 | doi= | pmc=PMC1194766 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1774048  }} </ref>


==References==
==References==

Revision as of 16:10, 4 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]; Nate Michalak, B.A.

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Overview

Pathophysiology

Transmission

  • Klebsiella granulomatis may be transmitted through sexual contact.
  • Although donovanosisis is typically considered a sexually transmitted disease, studies indicate it may also develop through fecal contamination or dermal contact.
  • K. granulomatis may also autoinoculate, resulting in multiple lesions that appear to be mirror images of each other.[1]

Pathogenesis

Virulence Factors

Adhesion

Associated Conditions

Microscopic Pathology

References

  1. O'Farrell N (2002). "Donovanosis". Sex Transm Infect. 78 (6): 452–7. PMC 1758360. PMID 12473810.
  2. Richens J (1991). "The diagnosis and treatment of donovanosis (granuloma inguinale)". Genitourin Med. 67 (6): 441–52. PMC 1194766. PMID 1774048.

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