Gliomatosis cerebri natural history, complications, and prognosis: Difference between revisions
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==Prognosis== | ==Prognosis== | ||
Prognosis of gliomatosis cerebri is generally poor, and the 5-year survival rate of patients with treatment is approximately 17.7%.<ref name="pmid21301914">{{cite journal| author=Inoue T, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T| title=Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases. | journal=Neurosurg Rev | year= 2010 | volume= 34 | issue= 2 | pages= 197-208 | pmid=21301914 | doi=10.1007/s10143-010-0306-1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21301914 }} </ref> | Prognosis of gliomatosis cerebri is generally poor, and the 5-year survival rate of patients with treatment is approximately 17.7%.<ref name="pmid21301914">{{cite journal| author=Inoue T, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T| title=Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases. | journal=Neurosurg Rev | year= 2010 | volume= 34 | issue= 2 | pages= 197-208 | pmid=21301914 | doi=10.1007/s10143-010-0306-1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21301914 }} </ref><ref name="pmid1759182">{{cite journal| author=Ross IB, Robitaille Y, Villemure JG, Tampieri D| title=Diagnosis and management of gliomatosis cerebri: recent trends. | journal=Surg Neurol | year= 1991 | volume= 36 | issue= 6 | pages= 431-40 | pmid=1759182 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1759182 }} </ref> | ||
The median survival time of gliomatosis cerebri is 14 months.<ref name="pmid12325066">{{cite journal| author=Herrlinger U, Felsberg J, Küker W, Bornemann A, Plasswilm L, Knobbe CB et al.| title=Gliomatosis cerebri: molecular pathology and clinical course. | journal=Ann Neurol | year= 2002 | volume= 52 | issue= 4 | pages= 390-9 | pmid=12325066 | doi=10.1002/ana.10297 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12325066 }} </ref> | The median survival time of gliomatosis cerebri is 14 months.<ref name="pmid12325066">{{cite journal| author=Herrlinger U, Felsberg J, Küker W, Bornemann A, Plasswilm L, Knobbe CB et al.| title=Gliomatosis cerebri: molecular pathology and clinical course. | journal=Ann Neurol | year= 2002 | volume= 52 | issue= 4 | pages= 390-9 | pmid=12325066 | doi=10.1002/ana.10297 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12325066 }} </ref> |
Revision as of 23:46, 1 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Natural History
- If left untreated, patients with meningioma may progress to develop focal neurological deficits, altered mental status, hydrocephalus, brain herniation, and ultimately death.
- Transformation into glioblastoma (grade 4) may occur a few years later.[1]
Complication
Common complications of gliomatosis cerebri include:[1]
- Brain herniation
- Hydrocephalus
- Coma
- Metastasis
- Recurrence
- Side effects of radiation therapy
- Side effects of chemotherapy
Prognosis
Prognosis of gliomatosis cerebri is generally poor, and the 5-year survival rate of patients with treatment is approximately 17.7%.[2][3]
The median survival time of gliomatosis cerebri is 14 months.[4]
The prognosis of gliomatosis cerebri depends on the following:
- Resectibility of the tumor mass
- Age of the patient
- Age < 10 year is associated with worse prognosis
- Gender of the patient
- Males are associated with a better prognosis than females
- Location of tumor
- Infratentorial tumor is associated with shorter survival.[4]
- Size of the tumor
- Stage of the cancer
- Primary diagnosis vs. recurrence
Complications
References
- ↑ 1.0 1.1 Treatment and prognosis of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri
- ↑ Inoue T, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T (2010). "Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases". Neurosurg Rev. 34 (2): 197–208. doi:10.1007/s10143-010-0306-1. PMID 21301914.
- ↑ Ross IB, Robitaille Y, Villemure JG, Tampieri D (1991). "Diagnosis and management of gliomatosis cerebri: recent trends". Surg Neurol. 36 (6): 431–40. PMID 1759182.
- ↑ 4.0 4.1 Herrlinger U, Felsberg J, Küker W, Bornemann A, Plasswilm L, Knobbe CB; et al. (2002). "Gliomatosis cerebri: molecular pathology and clinical course". Ann Neurol. 52 (4): 390–9. doi:10.1002/ana.10297. PMID 12325066.