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==Overview==
==Overview==
==MRI==
==MRI==
The tumor is distinctive on T1 and T2-weighted [[MRI]] with heterogeneous enhancement and typical location adjacent to and extension into the fourth ventricle.
* Brain MRI with gadolinium is the investigation of choice for the diagnosis of medulloblastoma.
Correct diagnosis of medulloblastoma may require ruling out [[ATRT|atypical teratoid rhabdoid tumor]] (ATRT)<ref>{{cite journal
* On brain MRI, medulloblastoma is characterized a mass located at the posterior fossa
| author = Burger PC
* Go
| coauthors = Yu I, Tihan T, et al
* MRI image characteristics observed among meningioma patients include:
| year = 1998
:* T1 weighted image illustrates a hypointense mass
| title = Atypical teratoid rhabdoid tumors of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group Study.
:* T1 C+ (Gd) image illustrates a heterogeneous enhancement in 90% of the cases
| journal = Am J Surg Pathol 1998
:* T2 weighted image illustrates a heterogeneous heperintense enhancement<br>
| issue = 22:
due to calcification, necrosis, and cyst formation
| pages = 1083-92
:* FLAIR MRI image may illustrates a:<ref name="pmid22209398">{{cite journal| author=Liu HQ, Yin X, Li Y, Zhang J, Wang Y, Tchoyoson Lim CC et al.| title=MRI features in children with desmoplastic medulloblastoma. | journal=J Clin Neurosci | year= 2012 | volume= 19 | issue= 2 | pages= 281-5 | pmid=22209398 | doi=10.1016/j.jocn.2011.04.029 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22209398 }} </ref>
| language = English
::* Localized areas of isointensity or hypointensity
  }}</ref> and [[primitive neuroectodermal tumor]] (PNET).
::* Radiating star-shaped enhancement
::* Multi-nodular enhancing pattern
 
 
 
DWI: shows restricted diffusion
MR spectroscopy: elevated choline, NAA decreased, may show a taurine peak 5
 
MRI is able to delineate the fourth ventricle and subarachnoid space to a much greater degree than CT. Although medulloblastomas project into the fourth ventricle, unlike ependymomas they do not usually extend into the basal cisterns 7.
 
As CSF seeding is common at presentation, imaging with godalinium contrast of the whole neuraxis is recommended to identify drop metastases and leptomeningeal spread. Although rare, extraneural spread is reported.


==Gallery==
==Gallery==

Revision as of 12:31, 1 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

MRI

  • Brain MRI with gadolinium is the investigation of choice for the diagnosis of medulloblastoma.
  • On brain MRI, medulloblastoma is characterized a mass located at the posterior fossa
  • Go
  • MRI image characteristics observed among meningioma patients include:
  • T1 weighted image illustrates a hypointense mass
  • T1 C+ (Gd) image illustrates a heterogeneous enhancement in 90% of the cases
  • T2 weighted image illustrates a heterogeneous heperintense enhancement

due to calcification, necrosis, and cyst formation

  • FLAIR MRI image may illustrates a:[1]
  • Localized areas of isointensity or hypointensity
  • Radiating star-shaped enhancement
  • Multi-nodular enhancing pattern


DWI: shows restricted diffusion MR spectroscopy: elevated choline, NAA decreased, may show a taurine peak 5

MRI is able to delineate the fourth ventricle and subarachnoid space to a much greater degree than CT. Although medulloblastomas project into the fourth ventricle, unlike ependymomas they do not usually extend into the basal cisterns 7.

As CSF seeding is common at presentation, imaging with godalinium contrast of the whole neuraxis is recommended to identify drop metastases and leptomeningeal spread. Although rare, extraneural spread is reported.

Gallery

(Images courtesy of RadsWiki)

Patient#1

Patient#2

References

  1. Liu HQ, Yin X, Li Y, Zhang J, Wang Y, Tchoyoson Lim CC; et al. (2012). "MRI features in children with desmoplastic medulloblastoma". J Clin Neurosci. 19 (2): 281–5. doi:10.1016/j.jocn.2011.04.029. PMID 22209398.


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