Multiple endocrine neoplasia type 2 other diagnostic studies: Difference between revisions
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===Histopathological Staining of the Biopsy=== | ===Histopathological Staining of the Biopsy=== | ||
* Histopathological staining of medullary thyroid cancer | * Histopathological staining of medullary thyroid cancer | ||
:(1)TTF1: negative in tumor cells | :(1) TTF1: negative in [[tumor]] cells | ||
:(2) | :(2) [[Calcitonin]]: positive in [[tumor]] [[cell]]s | ||
:(3) | :(3) [[Chromogranin]]: positive in [[tumor]] [[cell]]s | ||
:(4) | :(4) [[Synaptophysin]]: positive in [[tumor]] [[cell]]s | ||
==References== | ==References== |
Revision as of 23:29, 28 September 2015
Multiple endocrine neoplasia type 2 Microchapters |
Differentiating Multiple endocrine neoplasia type 2 from other Diseases |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Other diagnostic studies for multiple endocrine neoplasia type 2 include molecular genetic testing which include sequence analysis of select exons of mainly 10,11, 13-16 and sequence analysis of RET gene.
Other Diagnostic Studies
Molecular Genetic Testing
Test | Method |
---|---|
Select exon testing | Sequence analysis of select exons of mainly 10,11, 13-16 |
Single-gene testing | Sequence analysis of RET gene |
A multi-gene panel | RET and other genes of interest |
Histopathological Staining of the Biopsy
- Histopathological staining of medullary thyroid cancer
- (1) TTF1: negative in tumor cells
- (2) Calcitonin: positive in tumor cells
- (3) Chromogranin: positive in tumor cells
- (4) Synaptophysin: positive in tumor cells