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{{‪Creutzfeldt-Jakob disease‬}}
{{‪Creutzfeldt-Jakob disease‬}}
{{CMG}}  
{{CMG}} {{AE}}{{MMJ}}
==Overview==
Creutzfeldt Jakob disease was first described in 1920-1921 by two German [[neurologists]], Hans Gerhard Creutzfeldt and Alfons Maria Jakob. Creutzfeldt Jakob disease was first described in 1920-1921 by two German [[neurologist]]s, [[Hans Gerhard Creutzfeldt]] and [[Alfons Maria Jakob]]. The term ''Creutzfeldt Jakob'' was first coined by Spielmeyer in 1922 in honor of Creutzfeldt and Jakob's report. In 1997, [[Stanley B. Prusiner]] was awarded the Nobel Prize in [[physiology]] or medicine for his discovery of [[prion]]s. In 2007, Laura Manuelidis, an American [[neuropathologist]], and her colleagues described a [[virus]]-like particle without [[nucleic acid]] in less than 10% of the cells a [[scrapie]]-infected cell line and in a mouse cell line infected by a human  Creutzfeldt Jakob disease agent.


==Historical Perspective==
==Historical Perspective==
The disease was first described by two German [[neurologist]]s, [[Hans Gerhard Creutzfeldt]] and [[Alfons Maria Jakob]]. Some of the clinical findings described in their first papers do not match current criteria for Creutzfeldt-Jakob disease, and it is considered highly likely that at least two of the patients in initial studies were suffering from a different disorder.
*Creutzfeldt Jakob disease was first described in 1920-1921 by two German [[neurologist]]s, [[Hans Gerhard Creutzfeldt]] and [[Alfons Maria Jakob]].
 
*The term ''Creutzfeldt Jakob'' was first coined by Spielmeyer in 1922 in honor of Creutzfeldt and Jakob's report.<ref name="McKintosh-2003">{{Cite journal  | last1 = McKintosh | first1 = E. | last2 = Tabrizi | first2 = SJ. | last3 = Collinge | first3 = J. | title = Prion diseases. | journal = J Neurovirol | volume = 9 | issue = 2 | pages = 183-93 | month = Apr | year = 2003 | doi = 10.1080/13550280390194082 | PMID = 12707849 }}</ref>
[[Stanley B. Prusiner]] was awarded the [[Nobel Prize in physiology or medicine]] in 1997 for his discovery of [[prion]]s. For more than a decade, Yale University [[neuropathologist]] [[Laura Manuelidis]] has been challenging this explanation for the disease.  In January 2007 she and her colleagues published an article in the [[Proceedings of the National Academy of Science]] and reported that they have found a [[virus]]-like particle (but without finding [[nucleic acid]]s so far) in less than 10% of the cells a scrapie-infected cell line and in a mouse cell line infected by a human CJD agent.<ref name="Manuelidis2007">{{cite journal| author=Manuelidis L| coauthors=Yu ZX, Barquero N, Mullins B|date=February 6, 2007| title=Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles| journal=Proceedings of the National Academy of Science| volume=104| issue=6| pages=1975-1970| pmid=17267596|url=http://www.pnas.org/cgi/content/full/104/6/1965| accessdate=2007-09-24}}</ref>
* In 1997, [[Stanley B. Prusiner]] was awarded the Nobel Prize in physiology or medicine for his discovery of [[prion]]s.  
*In 2007, Laura Manuelidis, an American [[Neuropathologist|neuropathologis]]<nowiki/>t, and her colleagues described a [[virus]]-like particle without [[nucleic acid]] in less than 10% of the cells a [[scrapie]]-infected cell line and in a mouse cell line infected by a human Creutzfeldt Jakob disease agent.<ref name="Manuelidis2007">{{cite journal| author=Manuelidis L| coauthors=Yu ZX, Barquero N, Mullins B|date=February 6, 2007| title=Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles| journal=Proceedings of the National Academy of Science| volume=104| issue=6| pages=1975-1970| pmid=17267596|url=http://www.pnas.org/cgi/content/full/104/6/1965| accessdate=2007-09-24}}</ref>


==References==
==References==
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Latest revision as of 16:13, 19 October 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

Creutzfeldt Jakob disease was first described in 1920-1921 by two German neurologists, Hans Gerhard Creutzfeldt and Alfons Maria Jakob. Creutzfeldt Jakob disease was first described in 1920-1921 by two German neurologists, Hans Gerhard Creutzfeldt and Alfons Maria Jakob. The term Creutzfeldt Jakob was first coined by Spielmeyer in 1922 in honor of Creutzfeldt and Jakob's report. In 1997, Stanley B. Prusiner was awarded the Nobel Prize in physiology or medicine for his discovery of prions. In 2007, Laura Manuelidis, an American neuropathologist, and her colleagues described a virus-like particle without nucleic acid in less than 10% of the cells a scrapie-infected cell line and in a mouse cell line infected by a human Creutzfeldt Jakob disease agent.

Historical Perspective

  • Creutzfeldt Jakob disease was first described in 1920-1921 by two German neurologists, Hans Gerhard Creutzfeldt and Alfons Maria Jakob.
  • The term Creutzfeldt Jakob was first coined by Spielmeyer in 1922 in honor of Creutzfeldt and Jakob's report.[1]
  • In 1997, Stanley B. Prusiner was awarded the Nobel Prize in physiology or medicine for his discovery of prions.
  • In 2007, Laura Manuelidis, an American neuropathologist, and her colleagues described a virus-like particle without nucleic acid in less than 10% of the cells a scrapie-infected cell line and in a mouse cell line infected by a human Creutzfeldt Jakob disease agent.[2]

References

  1. McKintosh, E.; Tabrizi, SJ.; Collinge, J. (2003). "Prion diseases". J Neurovirol. 9 (2): 183–93. doi:10.1080/13550280390194082. PMID 12707849. Unknown parameter |month= ignored (help)
  2. Manuelidis L (February 6, 2007). "Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles". Proceedings of the National Academy of Science. 104 (6): 1975–1970. PMID 17267596. Retrieved 2007-09-24. Unknown parameter |coauthors= ignored (help)


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