Isosorbide mononitrate warnings: Difference between revisions

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__NOTOC__
#REDIRECT [[Isosorbide mononitrate#Warnings]]
{{Isosorbide mononitrate
}}
{{CMG}}; {{AE}} {{PB}}
 
 
 
===Warnings===
 
Amplification of the vasodilatory effects of Isosorbide mononitrate extended-release tablets by [[sildenafil]] can result in severe [[hypotension]]. The time course and dose dependence of this interaction have not been studied. Appropriate supportive care has not been studied, but it seems reasonable to treat this as a nitrate overdose, with elevation of the extremities and with central volume expansion.
 
The benefits of ISMN in patients with acute myocardial infarction or congestive heart failure have not been established; because the effects of ISMN are difficult to terminate rapidly, this drug is not recommended in these settings.
 
If ISMN is used in these conditions, careful clinical or hemodynamic monitoring must be used to avoid the hazards of [[hypotension]] and[[tachycardia]].
 
===Precautions===
 
=====General=====
 
Severe [[hypotension]], particularly with upright posture, may occur with even small doses of ISMN. This drug should therefore be used with caution in patients who may be volume depleted or who, for whatever reason, are already hypotensive. Hypotension induced by ISMN may be accompanied by paradoxical [[bradycardia]] and increased [[angina pectoris]].
 
Nitrate therapy may aggravate the [[angina]] caused by [[hypertrophic cardiomyopathy]].
 
In industrial workers who have had long term exposure to unknown (presumably high) doses of organic nitrates, tolerance clearly occurs. Chest pain,[[acute myocardial infarction]], and even sudden death have occurred during temporary withdrawal of nitrates from these workers, demonstrating the existence of true physical dependence. The importance of these observations to the routine, clinical use of oral ISMN is not known.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = ISOSORBIDE MONONITRATE TABLET [ZYDUS PHARMACEUTICALS (USA) INC.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=897a0327-25d4-4769-bd6a-0e674264017f | publisher =  | date =  | accessdate = 30 January 2014 }}</ref>
 
==References==
 
{{Reflist|2}}
 
[[Category:Drugs]]

Latest revision as of 22:42, 21 July 2014

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