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{{Relapsing fever}}
{{Relapsing fever}}
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==Overview==
==Overview==
[[Tick-borne relapsing fever|TBRF]] is endemic in the western US, southern British Columbia, plateau regions of Mexico, Central and South America, the Mediterranean, Central Asia, and much of Africa. In the United States. [[Louse-borne relapsing fever|LBRF]] is mainly a disease of the developing world. It is currently seen in Ethiopia and Sudan. [[Famine]], war, overcrowding, and the movement of refugee groups often result in [[Louse-borne relapsing fever|LBRF]] [[epidemics]]. With [[antibiotic]] treatment, the [[mortality]] of [[epidemic]] [[relapsing fever]] decreases from 10% to 40% to 2% to 4%.


== Epidemiology and Demographics ==
== Epidemiology and Demographics ==
TBRF is endemic in the western US, southern British Columbia, plateau regions of Mexico, Central and South America, the Mediterranean, Central Asia, and much of Africa. The first  endemic focus of TBRF in the US was identified in 1915 in Colorado (Meader 1915) though the first case was actually in 1905 in New York in a traveler to Texas.  Since then, TBRF has been reported in 14 states: Arizona, California, Colorado, Idaho, Kansas, Montana, Nevada, New Mexico, Ohio, Oklahoma, Oregon, Texas, Utah, Washington, and Wyoming. 
===Prevalnce===
 
*It is reported that 15 million cases of [[louse-borne relapsing fever]] ([[Louse-borne relapsing fever|LBRF]]) and more than 5 million deaths occurred in Africa, Eastern Europe, and Russia in the past.
Most recent cases and outbreaks have occurred in rustic cabin or vacation home settings at higher elevations (> 8,000 feet) in coniferous forests in the western US (Banerjee, Banerjee et al. 1998; Trevejo, Schriefer et al. 1998; Paul, Maupin et al. 2002; Centers for Disease and Prevention 2003; Schwan, Policastro et al. 2003).
 
TBRF normally occurs in summer months when people are traveling to mountainous areas on vacation.  TBRF can, however, occur in winter, particularly when people go into rodent infested cabins and start fires, warming the cabin and producing carbon dioxide and warmth that attract the ticks that transmit TBRF.
 
[[Image:TBRF by county.jpg|left|Map of reported cases of Tick-Borne relapsing fever by county, United States, 1990-2002]]  
 
''Reporting of TBRF''
 
Although TBRF was removed from the list of nationally notifiable conditions in 1987, 11 states require TBRF to be reported to their State Health Departments (Arizona, California, Colorado, Idaho, Nevada, New Mexico, Oregon, Texas, Utah, Washington, and Wyoming).  Other states such as Montana, may institute reporting in the future. <ref>http://www.cdc.gov/ncidod/dvbid/RelapsingFever/RF_Epidemiology.htm
</ref>
 
[[Image:TBRF by state.jpg|left|Map of reportable areas of the United States]]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 


===Incidence===
*In the early 1900s, many large epidemics were described, predominantly in Africa, the MiddleEast, India, and China. With improved hygiene, the incidence of epidemic relapsing fever has declined in the 20th century, but the disease continues to be a problem in countries of Africa, Asia, and South America.
*Only in North-Eastern Africa, especially the highlands of Ethiopia where an estimated 10,000 cases of [[Louse-borne relapsing fever|LBRF]] occur annually and affect mostly homeless people living in very unhygienic and crowded conditions especially during rainy seasons. <ref name="pmid25196787">{{cite journal |vauthors=Yimer M, Abera B, Mulu W, Bezabih B, Mohammed J |title=Prevalence and risk factors of louse-borne relapsing fever in high risk populations in Bahir Dar city Northwest, Ethiopia |journal=BMC Res Notes |volume=7 |issue= |pages=615 |date=September 2014 |pmid=25196787 |pmc=4175284 |doi=10.1186/1756-0500-7-615 |url=}}</ref>
*Only a few cases [[Tick-borne relapsing fever|TRBF]] are reported in the U.S. annually.


===Case-fatality rate/Mortality rate===
*The death rate for untreated [[Louse-borne relapsing fever|LBRF]] ranges from 10 - 70%. In [[Tick-borne relapsing fever|TBRF]], it is 4 -10%.
*With [[antibiotic]] treatment, the [[mortality]] of [[Louse-borne relapsing fever|epidemic relapsing fever]] decreases from 10% to 40% to 2% to 4%.
*Fatalities are lower in [[tick-borne disease]] compared to [[Louse-borne relapsing fever|louse-borne disease]], with treatment.<ref name="pmid5000337">{{cite journal |vauthors=Kolarík J |title=Different reaction of focal and diffuse epileptic EEG activity to psilocybin |journal=Act Nerv Super (Praha) |volume=13 |issue=3 |pages=215–6 |date=1971 |pmid=5000337 |doi= |url=}}</ref>
===Race===
* There is no [[racial]] predilection to [[relapsing fever]].


===Region===
*[[Tick-borne relapsing fever|TBRF]] is [[endemic]] in the western U.S., southern British Columbia, plateau regions of Mexico, Central and South America, the Mediterranean, Central Asia, and Africa.
*The first [[endemic]] region of [[Tick-borne relapsing fever|TBRF]] in the US was identified in 1915 in Colorado (Meader 1915). However, the first case was actually in 1905 in New York in a traveler to Texas. Since then, [[Tick-borne relapsing fever|TBRF]] has been reported in 14 states: Arizona, California, Colorado, Idaho, Kansas, Montana, Nevada, New Mexico, Ohio, Oklahoma, Oregon, Texas, Utah, Washington, and Wyoming. 
*Most recent cases and [[outbreaks]] have occurred in a rustic cabin or vacation home settings at higher elevations (> 8,000 feet) in coniferous forests in the western U.S.
*[[Tick-borne relapsing fever|TBRF]] occurs typically in summer months when people are traveling to mountainous areas on vacation. [[Tick-borne relapsing fever|TBRF]] can occur in winter, mainly when people go into rodent-infested cabins and start fires, warming the place and producing carbon dioxide and warmth that attract the ticks that transmit [[Tick-borne relapsing fever|TBRF]].


[[Image:TBRF by county.jpg|left|Map of reported cases of Tick-Borne relapsing fever by county, United States, 1990-2002]]


===Developed Countries===
*[[Tick-borne relapsing fever|TBRF]] is reported worldwide, except Antarctica, Australia, and the Pacific Southwest.
Although [[Tick-borne relapsing fever|TBRF]] was removed from the list of nationally notifiable conditions in 1987, 11 states require [[Tick-borne relapsing fever|TBRF]] to be reported to their State Health Departments (Arizona, California, Colorado, Idaho, Nevada, New Mexico, Oregon, Texas, Utah, Washington, and Wyoming).  Other states, such as Montana, may institute reporting in the future. <ref>http://www.cdc.gov/ncidod/dvbid/RelapsingFever/RF_Epidemiology.htm</ref>. Most cases of [[endemic]] [[relapsing fever]] occur in the late spring and summer.


===Devloping countries===
[[Louse-borne relapsing fever|LBRF]] is mainly a disease of the developing world. It is currently seen in Ethiopia and Sudan. [[Famine]], war, and the movement and groups of refugees often result in epidemics of [[Louse-borne relapsing fever|LBRF]]. The largest recent [[epidemics]] of [[Louse-borne relapsing fever|LBRF]] occurred during World Wars I and II. At least 1 million people died during these epidemics.<ref name=Cutler_2006>{{cite journal |author=Cutler S |title=Possibilities for relapsing fever reemergence |journal=Emerg Infect Dis |volume=12 |issue=3 |pages=369-74 |year=2006 |pmid=16704771}}</ref> it is currently prevalent in Ethiopia and Sudan.


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Needs content]]
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[[Category:Bacterial diseases]]
[[Category:Bacterial diseases]]
[[Category:Zoonoses]]
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Latest revision as of 05:50, 25 September 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

TBRF is endemic in the western US, southern British Columbia, plateau regions of Mexico, Central and South America, the Mediterranean, Central Asia, and much of Africa. In the United States. LBRF is mainly a disease of the developing world. It is currently seen in Ethiopia and Sudan. Famine, war, overcrowding, and the movement of refugee groups often result in LBRF epidemics. With antibiotic treatment, the mortality of epidemic relapsing fever decreases from 10% to 40% to 2% to 4%.

Epidemiology and Demographics

Prevalnce

  • It is reported that 15 million cases of louse-borne relapsing fever (LBRF) and more than 5 million deaths occurred in Africa, Eastern Europe, and Russia in the past.

Incidence

  • In the early 1900s, many large epidemics were described, predominantly in Africa, the MiddleEast, India, and China. With improved hygiene, the incidence of epidemic relapsing fever has declined in the 20th century, but the disease continues to be a problem in countries of Africa, Asia, and South America.
  • Only in North-Eastern Africa, especially the highlands of Ethiopia where an estimated 10,000 cases of LBRF occur annually and affect mostly homeless people living in very unhygienic and crowded conditions especially during rainy seasons. [1]
  • Only a few cases TRBF are reported in the U.S. annually.

Case-fatality rate/Mortality rate

Race

Region

  • TBRF is endemic in the western U.S., southern British Columbia, plateau regions of Mexico, Central and South America, the Mediterranean, Central Asia, and Africa.
  • The first endemic region of TBRF in the US was identified in 1915 in Colorado (Meader 1915). However, the first case was actually in 1905 in New York in a traveler to Texas. Since then, TBRF has been reported in 14 states: Arizona, California, Colorado, Idaho, Kansas, Montana, Nevada, New Mexico, Ohio, Oklahoma, Oregon, Texas, Utah, Washington, and Wyoming.
  • Most recent cases and outbreaks have occurred in a rustic cabin or vacation home settings at higher elevations (> 8,000 feet) in coniferous forests in the western U.S.
  • TBRF occurs typically in summer months when people are traveling to mountainous areas on vacation. TBRF can occur in winter, mainly when people go into rodent-infested cabins and start fires, warming the place and producing carbon dioxide and warmth that attract the ticks that transmit TBRF.
Map of reported cases of Tick-Borne relapsing fever by county, United States, 1990-2002
Map of reported cases of Tick-Borne relapsing fever by county, United States, 1990-2002

Developed Countries

  • TBRF is reported worldwide, except Antarctica, Australia, and the Pacific Southwest.

Although TBRF was removed from the list of nationally notifiable conditions in 1987, 11 states require TBRF to be reported to their State Health Departments (Arizona, California, Colorado, Idaho, Nevada, New Mexico, Oregon, Texas, Utah, Washington, and Wyoming). Other states, such as Montana, may institute reporting in the future. [3]. Most cases of endemic relapsing fever occur in the late spring and summer.

Devloping countries

LBRF is mainly a disease of the developing world. It is currently seen in Ethiopia and Sudan. Famine, war, and the movement and groups of refugees often result in epidemics of LBRF. The largest recent epidemics of LBRF occurred during World Wars I and II. At least 1 million people died during these epidemics.[4] it is currently prevalent in Ethiopia and Sudan.

References

  1. Yimer M, Abera B, Mulu W, Bezabih B, Mohammed J (September 2014). "Prevalence and risk factors of louse-borne relapsing fever in high risk populations in Bahir Dar city Northwest, Ethiopia". BMC Res Notes. 7: 615. doi:10.1186/1756-0500-7-615. PMC 4175284. PMID 25196787.
  2. Kolarík J (1971). "Different reaction of focal and diffuse epileptic EEG activity to psilocybin". Act Nerv Super (Praha). 13 (3): 215–6. PMID 5000337.
  3. http://www.cdc.gov/ncidod/dvbid/RelapsingFever/RF_Epidemiology.htm
  4. Cutler S (2006). "Possibilities for relapsing fever reemergence". Emerg Infect Dis. 12 (3): 369–74. PMID 16704771.