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{{Infobox_gene}}
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'''Pescadillo homolog''' is a [[protein]] that in humans is encoded by the ''PES1'' [[gene]].<ref name="pmid8985183">{{cite journal | vauthors = Allende ML, Amsterdam A, Becker T, Kawakami K, Gaiano N, Hopkins N | title = Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development | journal = Genes Dev | volume = 10 | issue = 24 | pages = 3141–55 |date=Jan 1997 | pmid = 8985183 | pmc =  | doi =10.1101/gad.10.24.3141 }}</ref><ref name="pmid10591208">{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP| title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 |date=Dec 1999 | pmid = 10591208 | pmc = | doi = 10.1038/990031 |display-authors=etal}}</ref><ref name="pmid17353269">{{cite journal | vauthors = Rohrmoser M, Holzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D | title = Interdependence of Pes1, Bop1, and WDR12 Controls Nucleolar Localization and Assembly of the PeBoW Complex Required for Maturation of the 60S Ribosomal Subunit | journal = Mol Cell Biol | volume = 27 | issue = 10 | pages = 3682–94 |date=May 2007 | pmid = 17353269 | pmc = 1899993 | doi = 10.1128/MCB.00172-07 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PES1 pescadillo homolog 1, containing BRCT domain (zebrafish)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23481| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pescadillo homolog 1, containing BRCT domain (zebrafish)
| HGNCid = 8848
| Symbol = PES1
| AltSymbols =; PES
| OMIM = 605819
| ECnumber =
| Homologene = 5984
| MGIid = 1890613
  | GeneAtlas_image1 = PBB_GE_PES1_202212_at_tn.png
  | Function =
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23481
    | Hs_Ensembl = ENSG00000100029
    | Hs_RefseqProtein = NP_055118
    | Hs_RefseqmRNA = NM_014303
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 29302613
    | Hs_GenLoc_end = 29333000
    | Hs_Uniprot = O00541
    | Mm_EntrezGene = 64934
    | Mm_Ensembl =
    | Mm_RefseqmRNA = NM_022889
    | Mm_RefseqProtein = NP_075027
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Pescadillo homolog 1, containing BRCT domain (zebrafish)''', also known as '''PES1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PES1 pescadillo homolog 1, containing BRCT domain (zebrafish)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23481| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.<ref name="entrez">{{cite web | title = Entrez Gene: PES1 pescadillo homolog 1, containing BRCT domain (zebrafish)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23481| accessdate = }}</ref>
| summary_text = This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Allende ML, Amsterdam A, Becker T, ''et al.'' |title=Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development. |journal=Genes Dev. |volume=10 |issue= 24 |pages= 3141-55 |year= 1997 |pmid= 8985183 |doi=  }}
*{{cite journal  |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal   |vauthors=Kinoshita Y, Jarell AD, Flaman JM, etal |title=Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6656–65 |year= 2001 |pmid= 11071894 |doi= 10.1074/jbc.M008536200 }}
*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal   |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Kinoshita Y, Jarell AD, Flaman JM, ''et al.'' |title=Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6656-65 |year= 2001 |pmid= 11071894 |doi= 10.1074/jbc.M008536200 }}
*{{cite journal   |vauthors=Oeffinger M, Leung A, Lamond A, etal |title=Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis |journal=RNA |volume=8 |issue= 5 |pages= 626–36 |year= 2002 |pmid= 12022229 |doi=10.1017/S1355838202020022  | pmc=1370283 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal   |vauthors=Scherl A, Couté Y, Déon C, etal |title=Functional Proteomic Analysis of Human Nucleolus |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617 }}
*{{cite journal | author=Oeffinger M, Leung A, Lamond A, ''et al.'' |title=Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis. |journal=RNA |volume=8 |issue= 5 |pages= 626-36 |year= 2002 |pmid= 12022229 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Lapik YR, Fernandes CJ, Lau LF, Pestov DG |title=Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis |journal=Mol. Cell |volume=15 |issue= 1 |pages= 17–29 |year= 2004 |pmid= 15225545 |doi= 10.1016/j.molcel.2004.05.020 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Maiorana A, Tu X, Cheng G, Baserga R |title=Role of pescadillo in the transformation and immortalization of mammalian cells |journal=Oncogene |volume=23 |issue= 42 |pages= 7116–24 |year= 2004 |pmid= 15273728 |doi= 10.1038/sj.onc.1207916 }}
*{{cite journal  | author=Lapik YR, Fernandes CJ, Lau LF, Pestov DG |title=Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. |journal=Mol. Cell |volume=15 |issue= 1 |pages= 17-29 |year= 2004 |pmid= 15225545 |doi= 10.1016/j.molcel.2004.05.020 }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal  | author=Maiorana A, Tu X, Cheng G, Baserga R |title=Role of pescadillo in the transformation and immortalization of mammalian cells. |journal=Oncogene |volume=23 |issue= 42 |pages= 7116-24 |year= 2004 |pmid= 15273728 |doi= 10.1038/sj.onc.1207916 }}
*{{cite journal   |vauthors=Killian A, Le Meur N, Sesboüé R, etal |title=Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability |journal=Oncogene |volume=23 |issue= 53 |pages= 8597–602 |year= 2004 |pmid= 15467761 |doi= 10.1038/sj.onc.1207845 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Killian A, Le Meur N, Sesboüé R, ''et al.'' |title=Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability. |journal=Oncogene |volume=23 |issue= 53 |pages= 8597-602 |year= 2004 |pmid= 15467761 |doi= 10.1038/sj.onc.1207845 }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Hölzel M, Rohrmoser M, Schlee M, etal |title=Mammalian WDR12 is a novel member of the Pes1–Bop1 complex and is required for ribosome biogenesis and cell proliferation |journal=J. Cell Biol. |volume=170 |issue= 3 |pages= 367–78 |year= 2005 |pmid= 16043514 |doi= 10.1083/jcb.200501141 | pmc=2171466 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
*{{cite journal | author=Hölzel M, Rohrmoser M, Schlee M, ''et al.'' |title=Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. |journal=J. Cell Biol. |volume=170 |issue= 3 |pages= 367-78 |year= 2005 |pmid= 16043514 |doi= 10.1083/jcb.200501141 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Rohrmoser M, Hölzel M, Grimm T, ''et al.'' |title=Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. |journal=Mol. Cell. Biol. |volume=27 |issue= 10 |pages= 3682-94 |year= 2007 |pmid= 17353269 |doi= 10.1128/MCB.00172-07 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 17:57, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.[1][2][3][4]

This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.[4]

References

  1. ↑ Allende ML, Amsterdam A, Becker T, Kawakami K, Gaiano N, Hopkins N (Jan 1997). "Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development". Genes Dev. 10 (24): 3141–55. doi:10.1101/gad.10.24.3141. PMID 8985183.
  2. ↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  3. ↑ Rohrmoser M, Holzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D (May 2007). "Interdependence of Pes1, Bop1, and WDR12 Controls Nucleolar Localization and Assembly of the PeBoW Complex Required for Maturation of the 60S Ribosomal Subunit". Mol Cell Biol. 27 (10): 3682–94. doi:10.1128/MCB.00172-07. PMC 1899993. PMID 17353269.
  4. ↑ 4.0 4.1 "Entrez Gene: PES1 pescadillo homolog 1, containing BRCT domain (zebrafish)".

Further reading



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