ARHGEF12: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Rho guanine nucleotide exchange factor 12''' is a [[protein]] that in humans is encoded by the ''ARHGEF12'' [[gene]].<ref name="pmid10681437">{{cite journal | vauthors = Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA | title = Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia | journal = Proc Natl Acad Sci U S A | volume = 97 | issue = 5 | pages = 2145–50 |date=April 2000 | pmid = 10681437 | pmc = 15768 | doi = 10.1073/pnas.040569197 }}</ref><ref name="pmid9205841">{{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 4 | issue = 2 | pages = 141–50 |date=September 1997 | pmid = 9205841 | pmc = | doi =10.1093/dnares/4.2.141  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23365| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ARHGEF12_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1txd.
| PDB = {{PDB2|1txd}}, {{PDB2|1x86}}
| Name = Rho guanine nucleotide exchange factor (GEF) 12
| HGNCid = 14193
| Symbol = ARHGEF12
| AltSymbols =; DKFZp686O2372; KIAA0382; LARG; PRO2792
| OMIM = 604763
| ECnumber = 
| Homologene = 9088
| MGIid = 1916882
| GeneAtlas_image1 = PBB_GE_ARHGEF12_201333_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ARHGEF12_201334_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ARHGEF12_201335_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23365
    | Hs_Ensembl = ENSG00000196914
    | Hs_RefseqProtein = NP_056128
    | Hs_RefseqmRNA = NM_015313
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 119713156
    | Hs_GenLoc_end = 119865855
    | Hs_Uniprot = Q9NZN5
    | Mm_EntrezGene = 69632
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_027144
    | Mm_RefseqProtein = NP_081420
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Rho guanine nucleotide exchange factor (GEF) 12''', also known as '''ARHGEF12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23365| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Rho family of GTPases|Rho GTPase]]s play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through [[G protein coupled receptor]] . The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
== Clinical significance ==
| summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.<ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23365| accessdate = }}</ref>
 
}}
This protein is observed to form myeloid/lymphoid fusion partner in [[acute myeloid leukemia]].<ref name="entrez"/>
 
==Interactions==
ARHGEF12 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[GNA12]],<ref name = pmid11094164/><ref name = pmid12515866/>
* [[GNA13]],<ref name = pmid11094164>{{cite journal | date = November 2000 | vauthors = Fukuhara S, Chikumi H, Gutkind JS | title = Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho | journal = FEBS Lett. | volume = 485 | issue = 2-3 | pages = 183–8 | pmid = 11094164 | doi = 10.1016/S0014-5793(00)02224-9}}</ref><ref name = pmid12515866>{{cite journal | date = January 2003 | vauthors = Suzuki N, Nakamura S, Mano H, Kozasa T | title = Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 2 | pages = 733–8 | pmid = 12515866 | pmc = 141065 | doi = 10.1073/pnas.0234057100}}</ref>
* [[Insulin-like growth factor 1 receptor|IGF1R]],<ref name = pmid11724822>{{cite journal | date = November 2001 | vauthors = Taya S, Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K | title = Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF | journal = J. Cell Biol. | volume = 155 | issue = 5 | pages = 809–20 | pmid = 11724822 | pmc = 2150867 | doi = 10.1083/jcb.200106139}}</ref>
* [[PLXNB1]],<ref name = pmid12220504>{{cite journal | date = September 2002 | vauthors = Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S | title = Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors | journal = Biochem. Biophys. Res. Commun. | volume = 297 | issue = 1 | pages = 32–7 | pmid = 12220504 | doi = 10.1016/S0006-291X(02)02122-8}}</ref>
* [[RHOA]],<ref name = pmid12515866/><ref name = pmid11373293>{{cite journal | date = July 2001 | vauthors = Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ | title = Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA | journal = J. Biol. Chem. | volume = 276 | issue = 29 | pages = 27145–51 | pmid = 11373293 | doi = 10.1074/jbc.M103565200}}</ref> and
* [[TEC (gene)|TEC]].<ref name = pmid12515866/>  
{{Div col end}}


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Fukuhara S, Chikumi H, Gutkind JS |title=Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho |journal=FEBS Lett. |volume=485 |issue= 2–3 |pages= 183–8 |year= 2000 |pmid= 11094164 |doi=10.1016/S0014-5793(00)02224-9 }}
| citations =
*{{cite journal  | vauthors=Reuther GW, Lambert QT, Booden MA |title=Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27145–51 |year= 2001 |pmid= 11373293 |doi= 10.1074/jbc.M103565200 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi=  }}
*{{cite journal  | vauthors=Taya S, Inagaki N, Sengiku H |title=Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF |journal=J. Cell Biol. |volume=155 |issue= 5 |pages= 809–20 |year= 2002 |pmid= 11724822 |doi= 10.1083/jcb.200106139 | pmc=2150867 |display-authors=etal}}
*{{cite journal  | author=Kourlas PJ, Strout MP, Becknell B, ''et al.'' |title=Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 5 |pages= 2145-50 |year= 2000 |pmid= 10681437 |doi= 10.1073/pnas.040569197 }}
*{{cite journal  | vauthors=Chikumi H, Fukuhara S, Gutkind JS |title=Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12463–73 |year= 2002 |pmid= 11799111 |doi= 10.1074/jbc.M108504200 }}
*{{cite journal  | author=Fukuhara S, Chikumi H, Gutkind JS |title=Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. |journal=FEBS Lett. |volume=485 |issue= 2-3 |pages= 183-8 |year= 2000 |pmid= 11094164 |doi=  }}
*{{cite journal  | vauthors=Perrot V, Vazquez-Prado J, Gutkind JS |title=Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43115–20 |year= 2003 |pmid= 12183458 |doi= 10.1074/jbc.M206005200 }}
*{{cite journal  | author=Reuther GW, Lambert QT, Booden MA, ''et al.'' |title=Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA. |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27145-51 |year= 2001 |pmid= 11373293 |doi= 10.1074/jbc.M103565200 }}
*{{cite journal  | vauthors=Aurandt J, Vikis HG, Gutkind JS |title=The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12085–90 |year= 2002 |pmid= 12196628 |doi= 10.1073/pnas.142433199  | pmc=129402 |display-authors=etal}}
*{{cite journal  | author=Taya S, Inagaki N, Sengiku H, ''et al.'' |title=Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF. |journal=J. Cell Biol. |volume=155 |issue= 5 |pages= 809-20 |year= 2002 |pmid= 11724822 |doi= 10.1083/jcb.200106139 }}
*{{cite journal  | vauthors=Hirotani M, Ohoka Y, Yamamoto T |title=Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 1 |pages= 32–7 |year= 2002 |pmid= 12220504 |doi=10.1016/S0006-291X(02)02122-8  |display-authors=etal}}
*{{cite journal  | author=Chikumi H, Fukuhara S, Gutkind JS |title=Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12463-73 |year= 2002 |pmid= 11799111 |doi= 10.1074/jbc.M108504200 }}
*{{cite journal  | vauthors=Driessens MH, Olivo C, Nagata K |title=B plexins activate Rho through PDZ-RhoGEF |journal=FEBS Lett. |volume=529 |issue= 2–3 |pages= 168–72 |year= 2002 |pmid= 12372594 |doi=10.1016/S0014-5793(02)03323-9  |display-authors=etal}}
*{{cite journal  | author=Perrot V, Vazquez-Prado J, Gutkind JS |title=Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43115-20 |year= 2003 |pmid= 12183458 |doi= 10.1074/jbc.M206005200 }}
*{{cite journal  | vauthors=Wennerberg K, Ellerbroek SM, Liu RY |title=RhoG signals in parallel with Rac1 and Cdc42 |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810–7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200 |display-authors=etal}}
*{{cite journal  | author=Aurandt J, Vikis HG, Gutkind JS, ''et al.'' |title=The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12085-90 |year= 2002 |pmid= 12196628 |doi= 10.1073/pnas.142433199 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Hirotani M, Ohoka Y, Yamamoto T, ''et al.'' |title=Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 1 |pages= 32-7 |year= 2002 |pmid= 12220504 |doi= }}
*{{cite journal  | vauthors=Suzuki N, Nakamura S, Mano H, Kozasa T |title=Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 733–8 |year= 2003 |pmid= 12515866 |doi= 10.1073/pnas.0234057100  | pmc=141065 }}
*{{cite journal  | author=Driessens MH, Olivo C, Nagata K, ''et al.'' |title=B plexins activate Rho through PDZ-RhoGEF. |journal=FEBS Lett. |volume=529 |issue= 2-3 |pages= 168-72 |year= 2002 |pmid= 12372594 |doi=  }}
*{{cite journal  | vauthors=Chikumi H, Barac A, Behbahani B |title=Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential |journal=Oncogene |volume=23 |issue= 1 |pages= 233–40 |year= 2004 |pmid= 14712228 |doi= 10.1038/sj.onc.1207012 |display-authors=etal}}
*{{cite journal  | author=Wennerberg K, Ellerbroek SM, Liu RY, ''et al.'' |title=RhoG signals in parallel with Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810-7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200 }}
*{{cite journal  | vauthors=Wang Q, Liu M, Kozasa T |title=Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 28831–4 |year= 2004 |pmid= 15143072 |doi= 10.1074/jbc.C400105200 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Kristelly R, Gao G, Tesmer JJ |title=Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47352–62 |year= 2004 |pmid= 15331592 |doi= 10.1074/jbc.M406056200 }}
*{{cite journal  | author=Suzuki N, Nakamura S, Mano H, Kozasa T |title=Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 733-8 |year= 2003 |pmid= 12515866 |doi= 10.1073/pnas.0234057100 }}
*{{cite journal  | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal}}
*{{cite journal  | author=Chikumi H, Barac A, Behbahani B, ''et al.'' |title=Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential. |journal=Oncogene |volume=23 |issue= 1 |pages= 233-40 |year= 2004 |pmid= 14712228 |doi= 10.1038/sj.onc.1207012 }}
*{{cite journal  | vauthors=Okuhira K, Fitzgerald ML, Sarracino DA |title=Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39653–64 |year= 2006 |pmid= 16192269 |doi= 10.1074/jbc.M510187200 |display-authors=etal}}
*{{cite journal  | author=Wang Q, Liu M, Kozasa T, ''et al.'' |title=Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 28831-4 |year= 2004 |pmid= 15143072 |doi= 10.1074/jbc.C400105200 }}
*{{cite journal  | vauthors=Goto M, Muramatsu H, Mihara H |title=Crystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction |journal=J. Biol. Chem. |volume=280 |issue= 49 |pages= 40875–84 |year= 2006 |pmid= 16192274 |doi= 10.1074/jbc.M507399200 |display-authors=etal}}
*{{cite journal  | author=Kristelly R, Gao G, Tesmer JJ |title=Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47352-62 |year= 2004 |pmid= 15331592 |doi= 10.1074/jbc.M406056200 }}
*{{cite journal  | vauthors=Bourguignon LY, Gilad E, Brightman A |title=Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells |journal=J. Biol. Chem. |volume=281 |issue= 20 |pages= 14026–40 |year= 2006 |pmid= 16565089 |doi= 10.1074/jbc.M507734200 |display-authors=etal}}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
{{Refend}}
*{{cite journal  | author=Okuhira K, Fitzgerald ML, Sarracino DA, ''et al.'' |title=Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39653-64 |year= 2006 |pmid= 16192269 |doi= 10.1074/jbc.M510187200 }}
 
*{{cite journal  | author=Goto M, Muramatsu H, Mihara H, ''et al.'' |title=Crystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction. |journal=J. Biol. Chem. |volume=280 |issue= 49 |pages= 40875-84 |year= 2006 |pmid= 16192274 |doi= 10.1074/jbc.M507399200 }}
==External links==
*{{cite journal  | author=Bourguignon LY, Gilad E, Brightman A, ''et al.'' |title=Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells. |journal=J. Biol. Chem. |volume=281 |issue= 20 |pages= 14026-40 |year= 2006 |pmid= 16565089 |doi= 10.1074/jbc.M507734200 }}
* {{UCSC gene info|ARHGEF12}}
}}
{{PDB Gallery|geneid=23365}}
{{refend}}
 


{{protein-stub}}
{{Gene-11-stub}}
{{WikiDoc Sources}}

Latest revision as of 18:13, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.[1][2][3]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptor . The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.[3]

Clinical significance

This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.[3]

Interactions

ARHGEF12 has been shown to interact with:

References

  1. ↑ Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA (April 2000). "Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia". Proc Natl Acad Sci U S A. 97 (5): 2145–50. doi:10.1073/pnas.040569197. PMC 15768. PMID 10681437.
  2. ↑ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  3. ↑ 3.0 3.1 3.2 "Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12".
  4. ↑ 4.0 4.1 Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164.
  5. ↑ 5.0 5.1 5.2 5.3 Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
  6. ↑ Taya S, Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K (November 2001). "Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF". J. Cell Biol. 155 (5): 809–20. doi:10.1083/jcb.200106139. PMC 2150867. PMID 11724822.
  7. ↑ Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (September 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.
  8. ↑ Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ (July 2001). "Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA". J. Biol. Chem. 276 (29): 27145–51. doi:10.1074/jbc.M103565200. PMID 11373293.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=ARHGEF12&oldid=1414895"