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| {{drugbox
| | #REDIRECT [[Bumetanide#Pharmacology]] |
| | IUPAC_name = 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid
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| | image = Bumetanide structure_svg.png
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| | image2 = Bumetanide_Bumex .gif
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| | width = 160px
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| | CAS_number = 28395-03-1
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| | ATC_prefix = C03
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| | ATC_suffix = CA02
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| | ATC_supplemental =
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| | PubChem = 2471
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| | DrugBank = APRD00294
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| | smiles = CCCCNc1cc(cc(c1Oc2ccccc2)S(N)(=O)=O)C(O)=O
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| | C = 17 | H = 20 | N = 2 | O = 5 | S = 1
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| | molecular_weight = 364.417 g/mol
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| | bioavailability = almost complete
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| | protein_bound = 97%
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| | metabolism = hepatic
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| | elimination_half-life = 60-90 minutes
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| | pregnancy_AU = B3
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| | pregnancy_US = C
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| | legal_AU = S4
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| | legal_UK = POM
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| | legal_US = Rx-only
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| | routes_of_administration = oral
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| | excretion = renal
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| }}
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| <!-- FAIR USE of Bumetanide_Bumex .gif: see image description page at http://en.wikipedia.org/wiki/Image:Bumetanide_Bumex .gif for rationale -->
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| {{CMG}}
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| ==[[Bumetanide (patient information)|For patient information, click here]]==
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| '''Bumetanide''' is a [[loop diuretic]] of the sulfamyl category to treat [[heart failure]]. It is often used in patients in whom high doses of [[furosemide]] are ineffective. It is marketed by [[Hoffmann-La Roche]] with the brand name Bumex. The main difference between the two substances is in [[bioavailability]]. Furosemide is incompletely absorbed in the intestine (40%), and there is substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.
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| Bumetanide is 40 times more potent than furosemide (for patients with normal [[renal function]]).
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| ==External links==
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| * [http://www.rocheusa.com/products/bumex/pi.pdf Bumex] (manufacturer's website)
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| * [http://www.meds-help.com/bumetanide/ Bumetanide] (patient information)
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| {{Antihypertensives and diuretics}}
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| [[th:บูมีทาไนด์]]
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| [[Category:Loop diuretics]]
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| [[Category:Drugs]]
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