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| {{Drugbox| | | {{Details0|Mesna (oral)}} |
| |IUPAC_name = sodium 2-sulfanylethanesulfonate
| | {{Details0|Mesna (injection)}} |
| | image = Mesna.svg
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| | CAS_number = 19767-45-4
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| | ATC_prefix = R05
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| | ATC_suffix = CB05
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| | ATC_supplemental = {{ATC|V03|AF01}}
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| | PubChem = 29769
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| | DrugBank =
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| | C= 2 | H= 5 | Na= 1 | O= 3 | S= 2
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| | molecular_weight = 164.181 [[Gram|g]]/[[Mole (unit)|mol]]
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| | bioavailability= 45–79% (Oral)
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| | metabolism = [[Oxidation|Oxidised]] in [[circulatory system|circulation]]
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| | elimination_half-life = 0.36–8.3 hours
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| | excretion = [[Renal]]
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| | pregnancy_category = B1 <small>([[Australia|Au]])</small>, B <small>([[United States|U.S.]])</small>
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| | legal_status = S4 <small>(Au)</small>, POM <small>([[United Kingdom|UK]])</small>, ℞-only <small>(U.S.)</small>
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| | routes_of_administration= Oral, intravenous
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| }} | |
| '''Mesna''' ([[International Nonproprietary Name|INN]]) ({{pronEng|ˈmɛznə}}) is an [[adjuvant]] used in cancer chemotherapy involving [[cyclophosphamide]] and [[ifosfamide]]. It is currently marketed by [[Baxter International|Baxter]] as '''Uromitexan'''® and '''Mesnex'''®.
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| Mesna is used therapeutically to reduce the incidence of [[hemorrhagic cystitis|haemorrhagic cystitis]] and [[hematuria|haematuria]] when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy. These two anticancer agents, ''in vivo'', may be converted to urotoxic metabolites such as [[acrolein]]. Mesna assists to neutralise these metabolites by binding through its [[sulfhydryl]]-moieties, and also increases urinary excretion of [[cysteine]].
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| ==External links==
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| * [http://www.bccancer.bc.ca/HPI/DrugDatabase/DrugIndexPro/Mesna.htm BC Cancer Agency]
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| * [http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202352.html NIH/Medline]
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| {{Cough and cold preparations}}
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| {{Detoxifying agents for antineoplastic treatment}}
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| [[Category:Chemotherapeutic adjuvants]]
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| {{Pharma-stub}}
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| [[de:Mesna]]
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| [[fr:Mesna]]
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| [[pl:Mesna]]
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| {{WikiDoc Sources}}
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