Papillary thyroid cancer natural history, complications and prognosis: Difference between revisions
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{{Papillary thyroid cancer}} | {{Papillary thyroid cancer}} | ||
{{CMG}}; {{AE}} {{Ammu}} | {{CMG}}; {{AE}} {{Ammu}} {{Sahar}} | ||
==Overview== | ==Overview== | ||
If left untreated, patients with papillary thyroid cancer may progress to develop metastasis. Common complications of papillary thyroid cancer include vocal cord compression, dysphagia, and dyspnea. The presence of metastasis is associated with a particularly poor prognosis among patients with papillary thyroid cancer. The | If left untreated, [[patients]] with papillary thyroid cancer may progress to develop [[metastasis]]. Common [[complications]] of papillary thyroid cancer include [[vocal cord]] compression, [[dysphagia]], and [[dyspnea]]. The presence of [[metastasis]] is associated with a particularly poor [[prognosis]] among [[patients]] with papillary thyroid cancer. The 10-year [[survival rate]] papillary thyroid cancer is 99%. | ||
==Natural History== | ==Natural History== | ||
The symptoms of papillary thyroid cancer usually develop in the third or fourth decade of life | * The [[symptoms]] of papillary thyroid cancer usually develop in the third or fourth decade of life and start with [[symptoms]] such as a painless lump in the neck.<ref name="pmid23083442">{{cite journal |vauthors=Randolph GW, Duh QY, Heller KS, LiVolsi VA, Mandel SJ, Steward DL, Tufano RP, Tuttle RM |title=The prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension |journal=Thyroid |volume=22 |issue=11 |pages=1144–52 |date=November 2012 |pmid=23083442 |doi=10.1089/thy.2012.0043 |url=}}</ref> | ||
* Without treatment, the [[patient]] will develop [[symptoms]] of compression and [[metastasis]], which may be fatal. | |||
==Complications== | ==Complications== | ||
* [[Metastasis]] | * [[Complications]] of papillary thyroid cancer include:<ref name="pmid23083442">{{cite journal |vauthors=Randolph GW, Duh QY, Heller KS, LiVolsi VA, Mandel SJ, Steward DL, Tufano RP, Tuttle RM |title=The prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension |journal=Thyroid |volume=22 |issue=11 |pages=1144–52 |date=November 2012 |pmid=23083442 |doi=10.1089/thy.2012.0043 |url=}}</ref> | ||
* | ** [[Metastasis]] | ||
* [[Dysphagia]] | ** Involvement of [[recurrent laryngeal nerve]] | ||
* [[Dyspnea]] | ** [[Dysphagia]] | ||
** [[Dyspnea]] | |||
==Prognosis== | ==Prognosis== | ||
* Prognosis is generally excellent, and the 10-year relative survival rate of patients with papillary thyroid cancer is approximately 99%.<ref name="urlCancer Statistics Review, 1975-2014 - SEER Statistics">{{cite web |url=https://seer.cancer.gov/archive/csr/1975_2014/ |title=Cancer Statistics Review, 1975-2014 - SEER Statistics |format= |work= |accessdate=}}</ref> | * [[Prognosis]] is generally excellent, and the 10-year relative [[survival rate]] of [[patients]] with papillary thyroid cancer is approximately 99%.<ref name="urlCancer Statistics Review, 1975-2014 - SEER Statistics">{{cite web |url=https://seer.cancer.gov/archive/csr/1975_2014/ |title=Cancer Statistics Review, 1975-2014 - SEER Statistics |format= |work= |accessdate=}}</ref> | ||
* Prognosis of patients with papillary thyroid cancer | * [[Prognosis]] of patients with papillary thyroid cancer depends on the following features:<ref name="Haymart2009">{{cite journal|last1=Haymart|first1=M. R.|title=Understanding the Relationship Between Age and Thyroid Cancer|journal=The Oncologist|volume=14|issue=3|year=2009|pages=216–221|issn=1083-7159|doi=10.1634/theoncologist.2008-0194}}</ref><ref name="McCONAHEYHay1986">{{cite journal|last1=McCONAHEY|first1=WILLIAM M.|last2=Hay|first2=Ian D.|last3=Woolner|first3=Lewis B.|last4=van HEERDEN|first4=JON A.|last5=Taylor|first5=William F.|title=Papillary Thyroid Cancer Treated at the Mayo Clinic, 1946 Through 1970: Initial Manifestations, Pathologic Findings, Therapy, and Outcome|journal=Mayo Clinic Proceedings|volume=61|issue=12|year=1986|pages=978–996|issn=00256196|doi=10.1016/S0025-6196(12)62641-X}}</ref> | ||
** Patient's age | |||
** Size of the [[tumor]] | |||
** Presence of [[metastatic]] [[disease]] | |||
** Presence of [[tumor]] [[invasion]] into adjacent tissues | |||
** Gender (male gender has been associated with higher mortality rate) | |||
===5 year Relative Survival Rate=== | ===5 year Relative Survival Rate=== | ||
* 5-year relative [[survival rate]] of papillary thyroid cancer depends on the [[invasion]] of the [[tumor]] at the time of [[diagnosis]].<ref name="urlSurvival Rates for Thyroid Cancer">{{cite web |url=https://www.cancer.org/cancer/thyroid-cancer/detection-diagnosis-staging/survival-rates.html |title=Survival Rates for Thyroid Cancer |format= |work= |accessdate=}}</ref> | * 5-year relative [[survival rate]] of papillary thyroid cancer depends on the [[invasion]] of the [[tumor]] at the time of [[diagnosis]].<ref name="urlSurvival Rates for Thyroid Cancer">{{cite web |url=https://www.cancer.org/cancer/thyroid-cancer/detection-diagnosis-staging/survival-rates.html |title=Survival Rates for Thyroid Cancer |format= |work= |accessdate=}}</ref> | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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{{WikiDoc Sources}} | |||
[[Category:Endocrine system]] | [[Category:Endocrine system]] | ||
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[[Category:Hereditary cancers]] | [[Category:Hereditary cancers]] | ||
[[Category:Thyroid disease]] | [[Category:Thyroid disease]] | ||
Latest revision as of 23:34, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2] Sahar Memar Montazerin, M.D.[3]
Overview
If left untreated, patients with papillary thyroid cancer may progress to develop metastasis. Common complications of papillary thyroid cancer include vocal cord compression, dysphagia, and dyspnea. The presence of metastasis is associated with a particularly poor prognosis among patients with papillary thyroid cancer. The 10-year survival rate papillary thyroid cancer is 99%.
Natural History
- The symptoms of papillary thyroid cancer usually develop in the third or fourth decade of life and start with symptoms such as a painless lump in the neck.[1]
- Without treatment, the patient will develop symptoms of compression and metastasis, which may be fatal.
Complications
- Complications of papillary thyroid cancer include:[1]
- Metastasis
- Involvement of recurrent laryngeal nerve
- Dysphagia
- Dyspnea
Prognosis
- Prognosis is generally excellent, and the 10-year relative survival rate of patients with papillary thyroid cancer is approximately 99%.[2]
- Prognosis of patients with papillary thyroid cancer depends on the following features:[3][4]
- Patient's age
- Size of the tumor
- Presence of metastatic disease
- Presence of tumor invasion into adjacent tissues
- Gender (male gender has been associated with higher mortality rate)
5 year Relative Survival Rate
- 5-year relative survival rate of papillary thyroid cancer depends on the invasion of the tumor at the time of diagnosis.[5]
- Localized tumor: 100%
- Tumor with regional metastasis: 100%
- Tumor with distant metastasis: 78%
References
- ↑ 1.0 1.1 Randolph GW, Duh QY, Heller KS, LiVolsi VA, Mandel SJ, Steward DL, Tufano RP, Tuttle RM (November 2012). "The prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension". Thyroid. 22 (11): 1144–52. doi:10.1089/thy.2012.0043. PMID 23083442.
- ↑ "Cancer Statistics Review, 1975-2014 - SEER Statistics".
- ↑ Haymart, M. R. (2009). "Understanding the Relationship Between Age and Thyroid Cancer". The Oncologist. 14 (3): 216–221. doi:10.1634/theoncologist.2008-0194. ISSN 1083-7159.
- ↑ McCONAHEY, WILLIAM M.; Hay, Ian D.; Woolner, Lewis B.; van HEERDEN, JON A.; Taylor, William F. (1986). "Papillary Thyroid Cancer Treated at the Mayo Clinic, 1946 Through 1970: Initial Manifestations, Pathologic Findings, Therapy, and Outcome". Mayo Clinic Proceedings. 61 (12): 978–996. doi:10.1016/S0025-6196(12)62641-X. ISSN 0025-6196.
- ↑ "Survival Rates for Thyroid Cancer".