ATG4D: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
The human '''ATG4D''' [[gene]] encodes the [[protein]] '''Autophagy related 4D, cysteine peptidase'''.<ref name="entrez">{{cite web | title = Entrez Gene: Autophagy related 4D, cysteine peptidase | url = https://www.ncbi.nlm.nih.gov/gene/84971 }}</ref>


The human '''ATG4D''' [[gene]] encodes the [[protein]] '''Autophagy related 4D, cysteine peptidase'''.
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: Autophagy related 4D, cysteine peptidase
| url = https://www.ncbi.nlm.nih.gov/gene/84971
| accessdate = 2014-04-15 <!-- T04:49:33.456503-08:00 -->
}}</ref>
 
==Function==


Autophagy is the process by which endogenous proteins and damaged [[organelles]] are destroyed intracellularly. Autophagy is postulated to be essential for cell [[Human homeostasis|homeostasis]] and cell remodeling during differentiation, [[metamorphosis]], non-[[Apoptosis|apoptotic]] cell death, and aging. Reduced levels of autophagy have been described in some malignant [[Neoplasm|tumor]]s, and a role for autophagy in controlling the unregulated cell growth linked to [[cancer]] has been proposed.  
Autophagy is the process by which endogenous proteins and damaged [[organelles]] are destroyed intracellularly. Autophagy is postulated to be essential for cell [[Human homeostasis|homeostasis]] and cell remodeling during differentiation, [[metamorphosis]], non-[[Apoptosis|apoptotic]] cell death, and aging. Reduced levels of autophagy have been described in some malignant [[Neoplasm|tumor]]s, and a role for autophagy in controlling the unregulated cell growth linked to [[cancer]] has been proposed.  
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== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal
* {{cite journal | vauthors = Betin VM, MacVicar TD, Parsons SF, Anstee DJ, Lane JD | title = A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress | journal = Autophagy | volume = 8 | issue = 4 | pages = 664–76 | date = April 2012 | pmid = 22441018 | pmc = 3405841 | doi = 10.4161/auto.19227 }}
| pmid = 22441018
* {{cite journal | vauthors = Betin VM, Lane JD | title = Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis | journal = Journal of Cell Science | volume = 122 | issue = Pt 14 | pages = 2554–66 | date = July 2009 | pmid = 19549685 | pmc = 2704886 | doi = 10.1242/jcs.046250 }}
| year = 2012
* {{cite journal | vauthors = Mariño G, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C | title = Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy | journal = The Journal of Biological Chemistry | volume = 278 | issue = 6 | pages = 3671–8 | date = February 2003 | pmid = 12446702 | doi = 10.1074/jbc.M208247200 }}
| author1 = Betin
| first1 = V. M.
| title = A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress
| journal = Autophagy
| volume = 8
| issue = 4
| pages = 664–76
| last2 = MacVicar
| first2 = T. D.
| last3 = Parsons
| first3 = S. F.
| last4 = Anstee
| first4 = D. J.
| last5 = Lane
| first5 = J. D.
| doi = 10.4161/auto.19227
| pmc = 3405841
}}
*{{Cite journal
| pmid = 19549685
| year = 2009
| author1 = Betin
| first1 = V. M.
| title = Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis
| journal = Journal of Cell Science
| volume = 122
| issue = Pt 14
| pages = 2554–66
| last2 = Lane
| first2 = J. D.
| doi = 10.1242/jcs.046250
| pmc = 2704886
}}
*{{Cite journal
| pmid = 12446702
| year = 2003
| author1 = Mariño
| first1 = G
| title = Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy
| journal = Journal of Biological Chemistry
| volume = 278
| issue = 6
| pages = 3671–8
| last2 = Uría
| first2 = J. A.
| last3 = Puente
| first3 = X. S.
| last4 = Quesada
| first4 = V
| last5 = Bordallo
| first5 = J
| last6 = López-Otín
| first6 = C
| doi = 10.1074/jbc.M208247200
}}
 
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}


{{gene-19-stub}}
{{gene-19-stub}}


[[Category:Human proteins]]
[[Category:Human proteins]]

Latest revision as of 07:50, 27 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.[1]

Function

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.

This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

References

  1. ↑ "Entrez Gene: Autophagy related 4D, cysteine peptidase".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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