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{{Infobox_gene}}
{{Infobox_gene}}
'''Mediator of RNA polymerase II transcription subunit 16''' is an [[enzyme]] that in humans is encoded by the ''MED16'' [[gene]].<ref name="pmid10235266">{{cite journal |vauthors=Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP | title = Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex | journal = Nature | volume = 398 | issue = 6730 | pages = 824–8 |date=Jun 1999 | pmid = 10235266 | pmc =  | doi = 10.1038/19783 }}</ref><ref name="pmid10198638">{{cite journal |vauthors=Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Mol Cell | volume = 3 | issue = 3 | pages = 361–70 |date=Apr 1999 | pmid = 10198638 | pmc =  | doi =10.1016/S1097-2765(00)80463-3  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10025| accessdate = }}</ref>
'''Mediator of RNA polymerase II transcription subunit 16''' is an [[enzyme]] that in humans is encoded by the ''MED16'' [[gene]].<ref name="pmid10235266">{{cite journal |vauthors=Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP | title = Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex | journal = Nature | volume = 398 | issue = 6730 | pages = 824–8 |date=Jun 1999 | pmid = 10235266 | pmc =  | doi = 10.1038/19783 | bibcode =1999Natur.398..824R }}</ref><ref name="pmid10198638">{{cite journal |vauthors=Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Mol Cell | volume = 3 | issue = 3 | pages = 361–70 |date=Apr 1999 | pmid = 10198638 | pmc =  | doi =10.1016/S1097-2765(00)80463-3  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10025| accessdate = }}</ref>


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==Interactions==
==Interactions==
MED16 has been shown to [[Protein-protein interaction|interact]] with [[Thyroid hormone receptor alpha]],<ref name=pmid10198638 /> [[Estrogen receptor alpha]]<ref name=pmid11867769>{{cite journal |last=Kang |first=Yun Kyoung |authorlink= |author2=Guermah Mohamed |author3=Yuan Chao-Xing |author4=Roeder Robert G  |date=Mar 2002 |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=99 |issue=5 |pages=2642–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11867769 |doi = 10.1073/pnas.261715899 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=122401 }}</ref> and [[Cyclin-dependent kinase 8]].<ref name=pmid10198638/><ref name=pmid11867769/>
MED16 has been shown to [[Protein-protein interaction|interact]] with [[Thyroid hormone receptor alpha]],<ref name=pmid10198638 /> [[Estrogen receptor alpha]]<ref name=pmid11867769>{{cite journal |last=Kang |first=Yun Kyoung |authorlink= |author2=Guermah Mohamed |author3=Yuan Chao-Xing |author4=Roeder Robert G  |date=Mar 2002 |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=99 |issue=5 |pages=2642–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11867769 |doi = 10.1073/pnas.261715899 | bibcode =2002PNAS...99.2642K | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=122401 }}</ref> and [[Cyclin-dependent kinase 8]].<ref name=pmid10198638/><ref name=pmid11867769/>


==References==
==References==
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| citations =  
| citations =  
*{{cite journal  |vauthors=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329–33 |year= 1996 |pmid= 8710870 |doi=10.1073/pnas.93.16.8329  | pmc=38670  }}
*{{cite journal  |vauthors=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329–33 |year= 1996 |pmid= 8710870 |doi=10.1073/pnas.93.16.8329  | pmc=38670  |bibcode=1996PNAS...93.8329F }}
*{{cite journal  |vauthors=Suzuki Y, Tsunoda T, Sese J, etal |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001 | pmc=311086 }}
*{{cite journal  |vauthors=Suzuki Y, Tsunoda T, Sese J, etal |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.gr-1640r | pmc=311086 }}
*{{cite journal  |vauthors=Wang Q, Sharma D, Ren Y, Fondell JD |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42852–8 |year= 2003 |pmid= 12218053 |doi= 10.1074/jbc.M206061200 }}
*{{cite journal  |vauthors=Wang Q, Sharma D, Ren Y, Fondell JD |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42852–8 |year= 2003 |pmid= 12218053 |doi= 10.1074/jbc.M206061200 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Sato S, Tomomori-Sato C, Banks CA, etal |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }}
*{{cite journal  |vauthors=Sato S, Tomomori-Sato C, Banks CA, etal |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }}
*{{cite journal  |vauthors=Wallberg AE, Yamamura S, Malik S, etal |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1137–49 |year= 2004 |pmid= 14636573 |doi=10.1016/S1097-2765(03)00391-5  }}
*{{cite journal  |vauthors=Wallberg AE, Yamamura S, Malik S, etal |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1137–49 |year= 2004 |pmid= 14636573 |doi=10.1016/S1097-2765(03)00391-5  }}

Latest revision as of 03:39, 25 June 2018

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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View/Edit Human

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.[1][2][3]


Interactions

MED16 has been shown to interact with Thyroid hormone receptor alpha,[2] Estrogen receptor alpha[4] and Cyclin-dependent kinase 8.[2][4]

References

  1. ↑ Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID 10235266.
  2. ↑ 2.0 2.1 2.2 Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
  3. ↑ "Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5".
  4. ↑ 4.0 4.1 Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. United States. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.

Further reading

External links



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