FLII: Difference between revisions
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| summary_text = This gene encodes a protein with a [[gelsolin]]-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.<ref name="pmid24155256">{{cite journal | authors = Ghoshdastider U, Popp D, Burtnick LD, Robinson RC | title = The expanding superfamily of gelsolin homology domain proteins | journal = Cytoskeleton | | summary_text = This gene encodes a protein with a [[gelsolin]]-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.<ref name="pmid24155256">{{cite journal | authors = Ghoshdastider U, Popp D, Burtnick LD, Robinson RC | title = The expanding superfamily of gelsolin homology domain proteins | journal = Cytoskeleton | volume = 70 | issue = 11 | pages = 775–95 | year = 2013 | pmid = 24155256 | doi = 10.1002/cm.21149 }}</ref> The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.<ref name="entrez">{{cite web | title = Entrez Gene: FLII flightless I homolog (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2314| accessdate = }}</ref> | ||
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{{PBB_Further_reading | {{PBB_Further_reading | ||
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*{{cite journal |vauthors=Campbell HD, Schimansky T, Claudianos C |title=The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 11386–90 |year= 1994 |pmid= 8248259 |doi=10.1073/pnas.90.23.11386 | pmc=47987 |display-authors=etal}} | *{{cite journal |vauthors=Campbell HD, Schimansky T, Claudianos C |title=The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 11386–90 |year= 1994 |pmid= 8248259 |doi=10.1073/pnas.90.23.11386 | pmc=47987 |display-authors=etal|bibcode=1993PNAS...9011386C}} | ||
*{{cite journal |vauthors=Campbell HD, Fountain S, Young IG |title=Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. |journal=Genomics |volume=42 |issue= 1 |pages= 46–54 |year= 1997 |pmid= 9177775 |doi= 10.1006/geno.1997.4709 |display-authors=etal}} | *{{cite journal |vauthors=Campbell HD, Fountain S, Young IG |title=Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. |journal=Genomics |volume=42 |issue= 1 |pages= 46–54 |year= 1997 |pmid= 9177775 |doi= 10.1006/geno.1997.4709 |display-authors=etal}} | ||
*{{cite journal |vauthors=Liu YT, Yin HL |title=Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 7920–7 |year= 1998 |pmid= 9525888 |doi=10.1074/jbc.273.14.7920 }} | *{{cite journal |vauthors=Liu YT, Yin HL |title=Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 7920–7 |year= 1998 |pmid= 9525888 |doi=10.1074/jbc.273.14.7920 }} | ||
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*{{cite journal |vauthors=Campbell HD, Fountain S, McLennan IS |title=Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3518–26 |year= 2002 |pmid= 11971982 |doi=10.1128/MCB.22.10.3518-3526.2002 | pmc=133791 |display-authors=etal}} | *{{cite journal |vauthors=Campbell HD, Fountain S, McLennan IS |title=Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3518–26 |year= 2002 |pmid= 11971982 |doi=10.1128/MCB.22.10.3518-3526.2002 | pmc=133791 |display-authors=etal}} | ||
*{{cite journal |vauthors=Bi W, Yan J, Stankiewicz P |title=Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. |journal=Genome Res. |volume=12 |issue= 5 |pages= 713–28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702 | pmc=186594 |display-authors=etal}} | *{{cite journal |vauthors=Bi W, Yan J, Stankiewicz P |title=Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. |journal=Genome Res. |volume=12 |issue= 5 |pages= 713–28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702 | pmc=186594 |display-authors=etal}} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}} | *{{cite journal |vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}} | ||
*{{cite journal |vauthors=Lee YH, Campbell HD, Stallcup MR |title=Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 2103–17 |year= 2004 |pmid= 14966289 |doi=10.1128/MCB.24.5.2103-2117.2004 | pmc=350567 }} | *{{cite journal |vauthors=Lee YH, Campbell HD, Stallcup MR |title=Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 2103–17 |year= 2004 |pmid= 14966289 |doi=10.1128/MCB.24.5.2103-2117.2004 | pmc=350567 }} | ||
*{{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}} | *{{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal|bibcode=2004PNAS..10112130B }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal |vauthors=Wang T, Chuang TH, Ronni T |title=Flightless I homolog negatively modulates the TLR pathway. |journal=J. Immunol. |volume=176 |issue= 3 |pages= 1355–62 |year= 2006 |pmid= 16424162 |doi= 10.4049/jimmunol.176.3.1355|display-authors=etal}} | *{{cite journal |vauthors=Wang T, Chuang TH, Ronni T |title=Flightless I homolog negatively modulates the TLR pathway. |journal=J. Immunol. |volume=176 |issue= 3 |pages= 1355–62 |year= 2006 |pmid= 16424162 |doi= 10.4049/jimmunol.176.3.1355|display-authors=etal}} | ||
Latest revision as of 02:31, 20 September 2018
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Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.[1][2]
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.[3] The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[2]
Interactions
FLII has been shown to interact with LRRFIP1[4][5] and TRAF interacting protein.[6]
References
- ↑ Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336. PMID 7825574.
- ↑ 2.0 2.1 "Entrez Gene: FLII flightless I homolog (Drosophila)".
- ↑ Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256.
- ↑ Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. UNITED STATES. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. ISSN 0021-9258. PMID 9525888.
- ↑ Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. UNITED STATES. 58 (2): 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446.
- ↑ Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. ENGLAND. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805.
Further reading
- Campbell HD, Schimansky T, Claudianos C, et al. (1994). "The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11386–90. Bibcode:1993PNAS...9011386C. doi:10.1073/pnas.90.23.11386. PMC 47987. PMID 8248259.
- Campbell HD, Fountain S, Young IG, et al. (1997). "Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL". Genomics. 42 (1): 46–54. doi:10.1006/geno.1997.4709. PMID 9177775.
- Liu YT, Yin HL (1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.
- Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I." Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
- Fong KS, de Couet HG (1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.
- Davy DA, Campbell HD, Fountain S, et al. (2001). "The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases". J. Cell Sci. 114 (Pt 3): 549–62. PMID 11171324.
- Campbell HD, Fountain S, McLennan IS, et al. (2002). "Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development". Mol. Cell. Biol. 22 (10): 3518–26. doi:10.1128/MCB.22.10.3518-3526.2002. PMC 133791. PMID 11971982.
- Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Lee YH, Campbell HD, Stallcup MR (2004). "Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity". Mol. Cell. Biol. 24 (5): 2103–17. doi:10.1128/MCB.24.5.2103-2117.2004. PMC 350567. PMID 14966289.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wang T, Chuang TH, Ronni T, et al. (2006). "Flightless I homolog negatively modulates the TLR pathway". J. Immunol. 176 (3): 1355–62. doi:10.4049/jimmunol.176.3.1355. PMID 16424162.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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