NME3: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Nucleoside diphosphate kinase 3''' is an [[enzyme]] that in humans is encoded by the ''NME3'' [[gene]].<ref name="pmid9067290">{{cite journal | vauthors = Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B | title = Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family | journal = Cancer Res. | volume = 57 | issue = 6 | pages = 1180–7 | date = April 1997 | pmid = 9067290 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NME3 non-metastatic cells 3, protein expressed in| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4832| accessdate = }}</ref>
'''Nucleoside diphosphate kinase 3''' is an [[enzyme]] that in humans is encoded by the ''NME3'' [[gene]].<ref name="pmid9067290">{{cite journal | vauthors = Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B | title = Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family | journal = Cancer Research | volume = 57 | issue = 6 | pages = 1180–7 | date = March 1997 | pmid = 9067290 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NME3 non-metastatic cells 3, protein expressed in| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4832| access-date = }}</ref>


== Interactions ==
== Interactions ==


NME3 has been shown to [[Protein-protein interaction|interact]] with [[NME1]]<ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid11042679>{{cite journal | vauthors = Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G | title = Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis | journal = Cell Death Differ. | volume = 7 | issue = 9 | pages = 843–50 | date = September 2000 | pmid = 11042679 | doi = 10.1038/sj.cdd.4400720 }}</ref> and [[NME2]].<ref name=pmid11042679/><ref name=pmid16169070>{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = September 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}</ref>
NME3 has been shown to [[Protein-protein interaction|interact]] with [[NME1]]<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | authorlink30 = Huda Zoghbi }}</ref><ref name=pmid11042679>{{cite journal | vauthors = Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G | title = Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis | journal = Cell Death and Differentiation | volume = 7 | issue = 9 | pages = 843–50 | date = September 2000 | pmid = 11042679 | doi = 10.1038/sj.cdd.4400720 }}</ref> and [[NME2]].<ref name=pmid11042679/><ref name=pmid16169070>{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = September 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}</ref>
 
== Clinical significance ==
 
Mutations in this gene have been associated with congenital [[hypotonia]], [[hypoventilation]] and cerebellar histopathological alterations.<ref name="Chen_2018">{{cite journal | vauthors = Chen CW, Wang HL, Huang CW, Huang CY, Lim WK, Tu IC, Koorapati A, Hsieh ST, Kan HW, Tzeng SR, Liao JC, Chong WM, Naroditzky I, Kidron D, Eran A, Nijim Y, Sela E, Feldman HB, Kalfon L, Raveh-Barak H, Falik-Zaccai TC, Elpeleg O, Mandel H, Chang ZF | title = Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder | journal = Proceedings of the National Academy of Sciences of the United States of America | volume =  | issue =  | date = December 2018 | pmid = 30587587 | doi = 10.1073/pnas.1818629116 }}</ref>


== References ==
== References ==
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== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Venturelli D, Martinez R, Melotti P, Casella I, Peschle C, Cucco C, Spampinato G, Darzynkiewicz Z, Calabretta B | title = Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 16 | pages = 7435–9 | year = 1995 | pmid = 7638209 | pmc = 41354 | doi = 10.1073/pnas.92.16.7435 }}
* {{cite journal | vauthors = Venturelli D, Martinez R, Melotti P, Casella I, Peschle C, Cucco C, Spampinato G, Darzynkiewicz Z, Calabretta B | title = Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 16 | pages = 7435–9 | date = August 1995 | pmid = 7638209 | pmc = 41354 | doi = 10.1073/pnas.92.16.7435 }}
* {{cite journal | vauthors = Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G | title = Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis | journal = Cell Death Differ. | volume = 7 | issue = 9 | pages = 843–50 | year = 2000 | pmid = 11042679 | doi = 10.1038/sj.cdd.4400720 }}
* {{cite journal | vauthors = Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G | title = Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis | journal = Cell Death and Differentiation | volume = 7 | issue = 9 | pages = 843–50 | date = September 2000 | pmid = 11042679 | doi = 10.1038/sj.cdd.4400720 }}
* {{cite journal | vauthors = Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR | title = Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 | journal = Hum. Mol. Genet. | volume = 10 | issue = 4 | pages = 339–52 | year = 2001 | pmid = 11157797 | doi = 10.1093/hmg/10.4.339 }}
* {{cite journal | vauthors = Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR | title = Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 | journal = Human Molecular Genetics | volume = 10 | issue = 4 | pages = 339–52 | date = February 2001 | pmid = 11157797 | doi = 10.1093/hmg/10.4.339 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL | title = p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 12 | pages = 4717–22 | year = 2006 | pmid = 16537434 | pmc = 1450237 | doi = 10.1073/pnas.0600585103 }}
* {{cite journal | vauthors = Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL | title = p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 12 | pages = 4717–22 | date = March 2006 | pmid = 16537434 | pmc = 1450237 | doi = 10.1073/pnas.0600585103 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
* {{cite journal | vauthors = Carinci F, Arcelli D, Lo Muzio L, Francioso F, Valentini D, Evangelisti R, Volinia S, D'Angelo A, Meroni G, Zollo M, Pastore A, Ionna F, Mastrangelo F, Conti P, Tetè S | title = Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma | journal = Transl Res | volume = 150 | issue = 4 | pages = 233–45 | year = 2007 | pmid = 17900511 | doi = 10.1016/j.trsl.2007.03.011 }}
* {{cite journal | vauthors = Carinci F, Arcelli D, Lo Muzio L, Francioso F, Valentini D, Evangelisti R, Volinia S, D'Angelo A, Meroni G, Zollo M, Pastore A, Ionna F, Mastrangelo F, Conti P, Tetè S | title = Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma | journal = Translational Research | volume = 150 | issue = 4 | pages = 233–45 | date = October 2007 | pmid = 17900511 | doi = 10.1016/j.trsl.2007.03.011 }}
{{refend}}
{{refend}}


{{PDB Gallery|geneid=4832}}
{{PDB Gallery|geneid=4832}}


{{Gene-16-stub}}
{{Gene-16-stub}}

Latest revision as of 09:22, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene.[1][2]

Interactions

NME3 has been shown to interact with NME1[3][4] and NME2.[4][5]

Clinical significance

Mutations in this gene have been associated with congenital hypotonia, hypoventilation and cerebellar histopathological alterations.[6]

References

  1. ↑ Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B (March 1997). "Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family". Cancer Research. 57 (6): 1180–7. PMID 9067290.
  2. ↑ "Entrez Gene: NME3 non-metastatic cells 3, protein expressed in".
  3. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  4. ↑ 4.0 4.1 Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death and Differentiation. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.
  5. ↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  6. ↑ Chen CW, Wang HL, Huang CW, Huang CY, Lim WK, Tu IC, Koorapati A, Hsieh ST, Kan HW, Tzeng SR, Liao JC, Chong WM, Naroditzky I, Kidron D, Eran A, Nijim Y, Sela E, Feldman HB, Kalfon L, Raveh-Barak H, Falik-Zaccai TC, Elpeleg O, Mandel H, Chang ZF (December 2018). "Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder". Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1818629116. PMID 30587587.

Further reading

  • Venturelli D, Martinez R, Melotti P, Casella I, Peschle C, Cucco C, Spampinato G, Darzynkiewicz Z, Calabretta B (August 1995). "Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7435–9. doi:10.1073/pnas.92.16.7435. PMC 41354. PMID 7638209.
  • Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death and Differentiation. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.
  • Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (February 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL (March 2006). "p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling". Proceedings of the National Academy of Sciences of the United States of America. 103 (12): 4717–22. doi:10.1073/pnas.0600585103. PMC 1450237. PMID 16537434.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Carinci F, Arcelli D, Lo Muzio L, Francioso F, Valentini D, Evangelisti R, Volinia S, D'Angelo A, Meroni G, Zollo M, Pastore A, Ionna F, Mastrangelo F, Conti P, Tetè S (October 2007). "Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma". Translational Research. 150 (4): 233–45. doi:10.1016/j.trsl.2007.03.011. PMID 17900511.
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