TMEM59: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Transmembrane protein 59''' is a [[protein]] that in humans is encoded by the ''TMEM59'' [[gene]].<ref name="pmid9653160">{{cite journal | vauthors = Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z | title = Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 14 | pages = 8175–80 |date=Aug 1998 | pmid = 9653160 | pmc = 20949 | doi =10.1073/pnas.95.14.8175 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TMEM59 transmembrane protein 59| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9528| accessdate = }}</ref>
'''Transmembrane protein 59''' is a [[protein]] that in humans is encoded by the ''TMEM59'' [[gene]].<ref name="pmid9653160">{{cite journal | vauthors = Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z | title = Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 14 | pages = 8175–80 | date = July 1998 | pmid = 9653160 | pmc = 20949 | doi = 10.1073/pnas.95.14.8175 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TMEM59 transmembrane protein 59| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9528| access-date = }}</ref>


TMEM59 is a membrane bound protein that is localized to the [[Golgi apparatus]].<ref name="Ullrich_2010">{{cite journal | vauthors = Ullrich S, Muench A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF | title = The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression and secretion of the amyloid precursor protein | journal = J Biol Chem | volume = 285| issue = 27| pages = 20664–74|date=April 2010 | pmid = 20427278 | pmc = 2898310 | doi = 10.1074/jbc.M109.055608 | url = | issn = }}</ref> The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi [[glycosylation]] of  [[amyloid precursor protein]] (APP) and blocks APP cleavage by the α- and β-[[amyloid precursor protein secretase]]s and therefore inhibits formation of the [[beta amyloid]] peptide that forms  [[amyloid]] plaques in [[Alzheimer's disease]].<ref name="Ullrich_2010"/>
TMEM59 is a membrane bound protein that is localized to the [[Golgi apparatus]].<ref name="Ullrich_2010">{{cite journal | vauthors = Ullrich S, Münch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF | title = The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein | journal = The Journal of Biological Chemistry | volume = 285 | issue = 27 | pages = 20664–74 | date = July 2010 | pmid = 20427278 | pmc = 2898310 | doi = 10.1074/jbc.M109.055608 }}</ref> The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi [[glycosylation]] of  [[amyloid precursor protein]] (APP) and blocks APP cleavage by the α- and β-[[amyloid precursor protein secretase]]s and therefore inhibits formation of the [[beta amyloid]] peptide that forms  [[amyloid]] plaques in [[Alzheimer's disease]].<ref name="Ullrich_2010"/>Moreover, TMEM59 has been shown to potentiate wnt siganling by promoting formation of the wnt receptor signalosomes. Transmembrane interactions between TMEM59 and the wnt receptor Frizzled were found to drive receptor multimerization that leads to improved potency and efficiacy of wnt signaling.<ref>{{cite journal | vauthors = Gerlach JP, Jordens I, Tauriello DV, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJ, Egan DA, Maurice MM | title = TMEM59 potentiates Wnt signaling by promoting signalosome formation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 115 | issue = 17 | pages = E3996-E4005 | date = April 2018 | pmid = 29632210 | pmc = 5924918 | doi = 10.1073/pnas.1721321115 }}</ref>


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Research | volume = 10 | issue = 10 | pages = 1546–60 | date = October 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Research | volume = 13 | issue = 10 | pages = 2265–70 | date = October 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934  }}
* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal  |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 23:13, 12 May 2018

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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View/Edit Human

Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene.[1][2]

TMEM59 is a membrane bound protein that is localized to the Golgi apparatus.[3] The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi glycosylation of amyloid precursor protein (APP) and blocks APP cleavage by the α- and β-amyloid precursor protein secretases and therefore inhibits formation of the beta amyloid peptide that forms amyloid plaques in Alzheimer's disease.[3]Moreover, TMEM59 has been shown to potentiate wnt siganling by promoting formation of the wnt receptor signalosomes. Transmembrane interactions between TMEM59 and the wnt receptor Frizzled were found to drive receptor multimerization that leads to improved potency and efficiacy of wnt signaling.[4]

References

  1. ↑ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  2. ↑ "Entrez Gene: TMEM59 transmembrane protein 59".
  3. ↑ 3.0 3.1 Ullrich S, Münch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (July 2010). "The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein". The Journal of Biological Chemistry. 285 (27): 20664–74. doi:10.1074/jbc.M109.055608. PMC 2898310. PMID 20427278.
  4. ↑ Gerlach JP, Jordens I, Tauriello DV, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJ, Egan DA, Maurice MM (April 2018). "TMEM59 potentiates Wnt signaling by promoting signalosome formation". Proceedings of the National Academy of Sciences of the United States of America. 115 (17): E3996–E4005. doi:10.1073/pnas.1721321115. PMC 5924918. PMID 29632210.

Further reading


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